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The third edition of the Handbook of Proteolytic Enzymes is a comprehensive reference work for the enzymes that cleave proteins and peptides, written by acknowledged experts in the field and containing over 850 chapters. Each chapter is organized into sections describing the name and history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features for a specific peptidase. There are also introductory chapters on peptidase classification and mechanisms and a comprehensive index. For the first time, the Handbook is also

Enzymology --- Proteolytic enzymes. --- Cellular control mechanisms. --- Cell regulation --- Biological control systems --- Cell metabolism --- Peptide hydrolases --- Proteases --- Hydrolases --- Proteolytic enzymes

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Stress, high blood pressure, smoking, pollution, fast foods, overweight, excessive travelling, surgery, less movement are common features in our modern life. These features are risky for blood clotting disorders. According to WHO, over 29% of the total mortalities worldwide are due to thrombosis. By the year, 2020 cardiovascular diseases (CVDs) may cause an estimated 25 million deaths per year, thus antithrombotic therapy is of great interest. The available thrombolytic agents such as urokinase are highly expensive, antigenic, quite unspecific, pyretogenic and hemorrhagenic. Therefore, the production of fibrinolysing enzymes, which rapidly dissolute thrombi within the vascular tree, without the detriments by microorganisms, as described in this book, is the desirable aim of today’s research.

Fibrinolytic agents. --- Fibrinolytic agents --- Organisms --- Fibrin Modulating Agents --- Endopeptidases --- Hematologic Agents --- Plasminogen Activators --- Cardiovascular Agents --- Blood Coagulation Factors --- Therapeutic Uses --- Molecular Mechanisms of Pharmacological Action --- Peptide Hydrolases --- Pharmacologic Actions --- Blood Proteins --- Hydrolases --- Chemical Actions and Uses --- Enzymes --- Proteins --- Chemicals and Drugs --- Enzymes and Coenzymes --- Amino Acids, Peptides, and Proteins --- Fibrinolytic Agents --- Streptokinase --- Bacteria --- Health & Biological Sciences --- Biology --- Pharmacy, Therapeutics, & Pharmacology --- Microbiology & Immunology --- Thrombosis. --- Anticoagulants (Medicine) --- Antithrombotic agents --- Blood thinners --- Blood thinning drugs --- Antithrombotics --- Fibrinolytic enzymes --- Fibrinolytics --- Thrombolytic agents --- Thrombolytics --- Medicine. --- Human physiology. --- Medical microbiology. --- Cardiology. --- Hematology. --- Biomedicine. --- Medical Microbiology. --- Human Physiology. --- Haematology --- Internal medicine --- Blood --- Heart --- Human biology --- Medical sciences --- Physiology --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Diseases --- Hematologic agents --- Cardiovascular system --- Protein C deficiency --- Protein S deficiency --- Coagulation --- Microbiology. --- Microbial biology --- Microorganisms