Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Highway-railroad grade crossings --- Railroads --- Safety measures. --- Signaling.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Signals and signaling --- Aids to navigation --- Inland water transportation --- Inland navigation --- Law and legislation

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The book is an edited collection of research articles covering the current state of sonar systems, the signal processing methods and their applications prepared by experts in the field. The first section is dedicated to the theory and applications of innovative synthetic aperture, interferometric, multistatic sonars and modeling and simulation. Special section in the book is dedicated to sonar signal processing methods covering: passive sonar array beamforming, direction of arrival estimation, signal detection and classification using DEMON and LOFAR principles, adaptive matched field signal processing. The image processing techniques include: image denoising, detection and classification of artificial mine like objects and application of hidden Markov model and artificial neural networks for signal classification. The biology applications include the analysis of biosonar capabilities and underwater sound influence on human hearing. The marine science applications include fish species target strength modeling, identification and discrimination from bottom scattering and pelagic biomass neural network estimation methods. Marine geology has place in the book with geomorphological parameters estimation from side scan sonar images. The book will be interesting not only for specialists in the area but also for readers as a guide in sonar systems principles of operation, signal processing methods and marine applications.

Sonar. --- Asdic --- Echo ranging --- Sound navigation ranging --- Detectors --- Electronics in navigation --- Signals and signaling, Submarine --- Ultrasonic equipment --- Underwater acoustics --- Acoustic & sound engineering

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This is an up-to-date reference and textbook on modern acoustics from a signal-theoretic point of view, as well as a wave-theoretic approach for students, engineers, and researchers. It provides readers the fundamental basis of acoustics and vibration science and proceeds up to recent hot topics related to acoustic transfer functions and signal analysis including a perceptual point of view. In the first part, the work uniquely introduces into the fundamentals without using heavy mathematics The following, advanced chapters deal with new and deep insights into acoustic signal analysis and investigation of room transfer functions based on the poles and zeros.

Acoustic signal processing. --- Acoustical engineering. --- Signal analysis. --- Sound propagation. --- Sound --- Signal theory (Telecommunication) --- Physics --- Civil & Environmental Engineering --- Physical Sciences & Mathematics --- Engineering & Applied Sciences --- Acoustics & Sound --- Civil Engineering --- Signals and signaling. --- Sound. --- Acoustics --- Coastal signals --- Military signaling --- Naval signaling --- Engineering. --- Acoustics. --- Engineering Acoustics. --- Signal, Image and Speech Processing. --- Acoustic engineering --- Sonic engineering --- Sonics --- Sound engineering --- Sound-waves --- Engineering --- Construction --- Industrial arts --- Technology --- Industrial applications --- Continuum mechanics --- Mathematical physics --- Pneumatics --- Radiation --- Wave-motion, Theory of --- Communication --- Communications, Military --- Marine service --- Naval art and science --- Navigation --- Signs and symbols --- Flags --- Acoustics in engineering. --- Signal processing. --- Image processing. --- Speech processing systems. --- Computational linguistics --- Electronic systems --- Information theory --- Modulation theory --- Oral communication --- Speech --- Telecommunication --- Singing voice synthesizers --- Pictorial data processing --- Picture processing --- Processing, Image --- Imaging systems --- Optical data processing --- Processing, Signal --- Information measurement

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The Wnt pathway is an evolutionarily conserved signaling network that is critical for mammalian development and adult tissue maintenance, and, importantly, hyperactivated in most human cancers. Almost two decades of study has confirmed that Wnt signaling is necessary and sufficient for cancer pathogenesis in multiple in vitro and in vivo models systems, suggesting that the pathway represents an attractive therapeutic target.  Recent efforts have focused on innovative strategies to antagonize Wnt signaling at various levels of the pathway – from attenuating the extracellular signaling through the Wnt receptors to modulating the catenin destruction complex to blocking catenin-mediated transcription. Many of these approaches have been largely successful in preclinical validation studies and have been met with considerable enthusiasm to move forward into clinical trials. In this book, we highlight the recent advances in our understanding of the complexity of the Wnt pathway, particularly its intricate regulation and cross-talk with other key signal transduction pathways in normal and tumor cells. As a way to comprehend the role of Wnt pathway activation in tumor initiation and progression, we discuss the importance of Wnt signaling in embryonic and tissue development and stem cell maintenance and self-renewal. The evidence for aberrant Wnt pathway activation in human solid and hematopoietic cancers, as well as a few of the genetic mouse models that mimic the Wnt pathway deregulation observed in some of these tumor types, is reviewed. Lastly, we summarize the current status of the development of Wnt pathway inhibitors, their efficacy in preclinical models and their potential as therapeutic agents for cancer. It is an exciting time in the Wnt signaling field – one that represents a key crossroad between dissecting the molecular details of the pathway and translating that work into promising targeted tumor therapies – that is likely to profoundly impact this research area for years to come.

Cancer -- Genetic aspects. --- Neoplasms -- genetics. --- Neoplasms -- therapy. --- Signal Transduction. --- Targeted Gene Repair -- methods. --- Wnt genes. --- Intercellular Signaling Peptides and Proteins --- Cell Physiological Processes --- Biology --- Biochemical Processes --- Gene Therapy --- Investigative Techniques --- Mutagenesis, Site-Directed --- Diseases --- Proteins --- Cell Physiological Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemical Processes --- Genetic Engineering --- Protein Engineering --- Biological Therapy --- Biochemical Phenomena --- Biological Factors --- Peptides --- Biological Science Disciplines --- Chemical Phenomena --- Therapeutics --- Amino Acids, Peptides, and Proteins --- Phenomena and Processes --- Chemicals and Drugs --- Natural Science Disciplines --- Genetic Techniques --- Disciplines and Occupations --- Wnt Proteins --- Neoplasms --- Signal Transduction --- Genetics --- Targeted Gene Repair --- Methods --- Medicine --- Health & Biological Sciences --- Oncology --- Cellular signal transduction. --- Wnt proteins. --- Cancer. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Medicine. --- Cancer research. --- Pharmacology. --- Oncology. --- Medicine & Public Health. --- Pharmacology/Toxicology. --- Cancer Research. --- Tumors --- Glycoproteins --- Growth factors --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Oncology  . --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Wnt pathway. --- Pathway, Wnt --- Signal transduction pathway, Wnt --- Signaling pathway, Wnt --- Wnt signal transduction pathway --- Wnt signaling pathway --- Cellular signal transduction --- Cancer research --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect