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We proudly present the first book to integrate all aspects of purinergic signaling in the respiratory system. The first chapters introduce basic notions of purinergic pharmacology and metabolism, which allows readers from all scientific backgrounds to fully grasp the importance of these signaling networks for airway defenses, including mucociliary clearance and inflammatory responses. Then, chapters are devoted to the groundbreaking discovery that chronic respiratory diseases, including asthma, cystic fibrosis and chronic obstructive pulmonary disease (COPD), present specific aberrances in purinergic signaling which essentially drive lung complications. The last chapters describe the animal models used to investigate purinergic signaling in respiratory diseases, and the therapeutic applications developed by the pharmaceutical industry based on receptor agonists/antagonists and metabolic correctors. This highly comprehensive manuscript constitutes an invaluable tool for beginners and experts to follow the rapidly evolving research field of purinergic signaling. Furthermore, the critical analysis of past clinical protocols should facilitate the identification of potent therapeutic targets, and provide a better understanding of the data acquired in current clinical trials.

Purines -- Receptors. --- Respiratory organs -- Diseases. --- Respiratory Tract Diseases. --- Respiratory organs --- Purines --- Cellular signal transduction --- Anatomy --- Receptors, Cell Surface --- Diseases --- Biochemical Processes --- Receptors, Neurotransmitter --- Cell Physiological Processes --- Receptors, G-Protein-Coupled --- Biochemical Phenomena --- Membrane Proteins --- Chemical Processes --- Cell Physiological Phenomena --- Phenomena and Processes --- Chemical Phenomena --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Respiratory Tract Diseases --- Respiratory System --- Receptors, Purinergic --- Signal Transduction --- Medicine --- Health & Biological Sciences --- Respiratory System Diseases --- Receptors --- Respiratory infections. --- Receptors. --- Purine receptors --- Purinergic receptors --- Purinoreceptors --- Respiratory tract infections --- Upper respiratory infections --- Upper respiratory tract infections --- Air passages (Anatomy) --- Respiratory system --- Infections --- Medicine. --- Pharmaceutical technology. --- Infectious diseases. --- Metabolic diseases. --- Traumatology. --- Biomedicine. --- Biomedicine general. --- Pneumology/Respiratory System. --- Pharmaceutical Sciences/Technology. --- Metabolic Diseases. --- Infectious Diseases. --- Traumatic Surgery. --- Diseases. --- Cell receptors --- Infection --- Cardiopulmonary system --- Pneumology. --- Emerging infectious diseases. --- Trauma. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Disorders of metabolism --- Metabolic diseases --- Metabolic disorders --- Metabolism, Disorders of --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Respiratory organs—Diseases. --- Biomedicine, general. --- Accident medicine --- Trauma medicine --- Emergency medicine --- Surgery --- Wounds and injuries --- Biology --- Pharmaceutical chemistry. --- Surgery. --- Biomedical Research. --- Pharmaceutics. --- General Surgery. --- Research. --- Surgery, Primitive --- Human beings --- Illness --- Illnesses --- Morbidity --- Sickness --- Sicknesses --- Epidemiology --- Health --- Sick --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry --- Respiratory diseases --- Biological research --- Biomedical research