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The discovery of adult neurogenesis caused a paradigm shift in the neurosciences. For more than 100 years, it was believed that adult neurons do not regenerate. Joseph Altman and Fernando Nottebohm found proof to the contrary and changed the course of history. Their research, included here, provides the foundations of the field. Today, adult neurogenesis is a rapidly expanding discipline applicable to the study of brain development and diseases, learning and memory, aging, and neuropsychiatric disorders. With multiple authors, the 27 chapters of this book contain the latest work in two volumes. The first presents the basic biology of adult neurogenesis in non-mammalian vertebrates and in the mammalian hippocampus and olfactory bulb, and the second discusses clinical implications and delves into adult neurogenesis and brain injury as well as neurodegenerative and neuropsychiatric pathologies. With details of the anatomy, physiology, and molecular biology of the two neurogenic brain regions, this book provides indispensable knowledge for many areas of neuroscience and for experimental and clinical applications of adult neurogenesis to brain therapy.

Developmental neurobiology. --- Neural stem cells. --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Neurology --- Neuroscience --- Nervous system --- Neurons. --- Regeneration. --- Nerve regeneration --- Nervous system regeneration --- Neural regeneration --- Neuron regeneration --- Developmental neurology --- Neurogenesis --- Nerve cells --- Neurocytes --- Degeneration and regeneration --- Medicine. --- Neurosciences. --- Neurology. --- Cell biology. --- Biomedicine. --- Cell Biology. --- Developmental biology --- Embryology --- Neurobiology --- Neuroplasticity --- Nerve grafting --- Regeneration (Biology) --- Cells --- Evolution --- Cytology. --- Neuropsychiatry --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Neural sciences --- Neurological sciences --- Medical sciences --- Diseases --- Neurology .

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Defined as, “The science about the development of an embryo from the fertilization of the ovum to the fetus stage,” embryology has been a mainstay at universities throughout the world for many years. Throughout the last century, embryology became overshadowed by experimental-based genetics and cell biology, transforming the field into developmental biology, which replaced embryology in Biology departments in many universities. Major contributions in this young century in the fields of molecular biology, biochemistry and genomics were integrated with both embryology and developmental biology to provide an understanding of the molecular portrait of a “development cell.” That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications. In addition, it covers other key relevant topics such as nuclear reprogramming induced pluripotency and stem cell culture techniques using novel biomaterials. A thorough introduction to stem-cell biology, this reference is aimed at graduate students, post-docs, and professors as well as executives and scientists in biotech and pharmaceutical companies.

Brain --Diseases --Treatment. --- Cellular therapy. --- Neural stem cells. --- Stem cells --- Regenerative medicine --- Tissue engineering --- Investigative Techniques --- Medicine --- Cells --- Culture Techniques --- Anatomy --- Clinical Laboratory Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Health Occupations --- Regenerative Medicine --- Stem Cells --- Tissue Engineering --- Methods --- Disciplines and Occupations --- Biology --- Health & Biological Sciences --- Cytology --- Research --- Research. --- Life sciences. --- Pharmacology. --- Biotechnology. --- Cell biology. --- Developmental biology. --- Animal genetics. --- Biophysics. --- Biological physics. --- Life Sciences. --- Cell Biology. --- Developmental Biology. --- Biophysics and Biological Physics. --- Animal Genetics and Genomics. --- Pharmacology/Toxicology. --- Biomedical engineering --- Tissue culture --- Regeneration (Biology) --- Cytology. --- Toxicology. --- Biological and Medical Physics, Biophysics. --- Chemical engineering --- Genetic engineering --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Genetics --- Development (Biology) --- Growth --- Ontogeny --- Cell biology --- Cellular biology --- Cytologists --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Biological physics --- Physics --- Physiological effect