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Current thinking holds that obesity derives primarily from overnutrition (though compelling arguments for other mechanisms, like endocrine disruption by environmental pollutants, also gain support from the literature). In animals, overnutrition is initially handled by adipose tissue expansion; however, exhaustion of this route of lipid sequestering results in oversupply of lipid to other tissues including skeletal muscle, heart, liver, and others. Failure of these tissues to clear excess lipids through either metabolism or sequestration into putatively inert triacylglycerols results in perturbation of bioactive lipid metabolism in cells. In particular, aberrant generation of bioactive sphingolipids is implicated in a multitude of pathological outcomes of metabolic disease including insulin resistance, inflammation, cardiomyopathy, and others. This volume addresses not only the fundamentals of sphingolipid metabolism and analysis, but also the roles of sphingolipids in these disease processes.
Metabolic Diseases -- pathology. --- Sphingolipidoses. --- Sphingolipids -- metabolism. --- Sphingolipids -- Pathophysiology. --- Sphingolipidoses --- Sphingolipids --- Nutritional and Metabolic Diseases --- Membrane Lipids --- Lipids --- Metabolic Phenomena --- Medicine --- Diseases --- Chemicals and Drugs --- Health Occupations --- Phenomena and Processes --- Disciplines and Occupations --- Metabolic Diseases --- Metabolism --- Pathology --- Biology --- Health & Biological Sciences --- Biophysics --- Pathophysiology --- Pathophysiology. --- Medicine. --- Molecular biology. --- Metabolic diseases. --- Biomedicine. --- Molecular Medicine. --- Metabolic Diseases. --- Disorders of metabolism --- Metabolic diseases --- Metabolic disorders --- Metabolism, Disorders of --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biomolecules --- Systems biology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Sphingosine --- Sphingolipid storage diseases --- Sphingolipidosis --- Storage diseases, Sphingolipid --- Lipidoses --- Lysosomal storage diseases --- Nervous system --- Health Workforce
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This compendium of research material on the role of oxidative stress in animal disease and morbidity examines both the general and the specific. Sourced from scientists, veterinarians, and members of the medical community from around the world, it includes chapters on our wider understanding of the corrosive function of free radicals in cell biology as well as focusing on the interplay between oxidative stress and metabolism in a variety of animal species including dogs, ruminants and birds. Since biogerontologist Denham Harman first posited that free radicals arising from the metabolic activity of oxygen play a central role in aging and disease, a mass of evidence has accumulated linking oxidative stress and biological degradation. We now understand that living in an aerobic environment inevitably leads to the production of free radicals that go on to attack biological membranes and lipoproteins via oxidation in a process called lipid peroxidation. Reacting with carbon-based molecules such as polyunsaturated fatty acids, these free radicals cause oxidative stress and tissue damage. The purpose of Studies on Veterinary Medicine is to inform clinicians, students and others of the plethora of consequences that free radical damage (ROS) has on various cells, tissues, and organs, as well as in different species of animals. The chapters also analyze the effects of oxidative stress on aging and various morbidities such as diabetes, cognitive dysfunction and heart disease. Contributors variously present their interpretation of the role played by oxidative damage in disease and assess the benefits of antioxidant therapies.
Oxidative stress --- Active oxygen in the body --- Active oxygen --- Membrane lipids --- Veterinary pathophysiology --- Stress, Physiological --- Metabolism --- Physiological Processes --- Metabolic Phenomena --- Phenomena and Processes --- Physiological Phenomena --- Oxidative Stress --- Health & Biological Sciences --- Biology --- Veterinary Medicine --- Cytology --- Pathophysiology --- Physiological effect --- Peroxidation --- Veterinary medicine. --- Farriery --- Large animal medicine --- Large animal veterinary medicine --- Livestock medicine --- Veterinary science --- Life sciences. --- Biochemistry. --- Cell biology. --- Oxidative stress. --- Zoology. --- Life Sciences. --- Oxidative Stress. --- Cell Biology. --- Animal Biochemistry. --- Veterinary Medicine. --- Medicine --- Animal health --- Animals --- Domestic animals --- Livestock --- Diseases --- Losses --- Cytology. --- Veterinary Medicine/Veterinary Science. --- Natural history --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Composition --- Oxidation-reduction reaction --- Stress (Physiology)
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