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Pharmaceutical industry --- Drug delivery systems --- Therapeutics --- Drug targeting --- Pharmacology --- Technological innovations --- Industries

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This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included.  Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.

Molecular biology --- Oncology. Neoplasms --- oncologie --- moleculaire biologie --- Neoplasms --- Antineoplastic Agents --- Drug Resistance, Neoplasm. --- Molecular Targeted Therapy. --- Cancer --- Drug targeting. --- Médicaments --- drug therapy. --- therapeutic use. --- Treatment. --- Traitement --- Ciblage --- EPUB-LIV-FT LIVMEDEC SPRINGER-B

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The discoveries highlighted in this book parallel the emergence of innovative “molecular targeted” small molecules and monoclonal antibodies, i.e. agents that target proteins within highly activated signal transduction pathways that control proliferation.  Many of the tumor-targeted strategies described within cross the boundaries between what’s considered to be “molecular targeted” versus conventional systemic therapy.  However, the main theme of this volume is the folate receptor (FR), with much of the content focused on its basic biology and regulation as well as its exploitation for targeted therapy and diagnostic imaging.

Cancer -- Chemotherapy. --- Drug targeting. --- Inflammation -- Treatment. --- Cancer --- Therapeutics --- Diseases --- Therapeutic Uses --- Pharmacologic Actions --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemical Actions and Uses --- Chemicals and Drugs --- Antineoplastic Agents --- Drug Delivery Systems --- Drug Therapy --- Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Chemotherapy --- Chemotherapy. --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Antineoplastic agents --- Treatment --- Oncology. --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Drugs --- Pharmacy --- Cancer research --- Physiological effect

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Drug delivery systems --- Médicaments --- Periodicals. --- Administration --- Dispositifs --- Périodiques --- Drug Delivery Systems. --- Drug Carriers. --- Drug Design. --- Drug delivery systems. --- pharmaceuticals --- drug carriers --- drug delivery systems --- drug implants --- virosomes --- excipients --- Delivery systems, Drug --- Drug administration technology --- Drug delivery technology --- Drugs --- Pharmaceutical technology --- Drug Modeling --- Design, Drug --- Designs, Drug --- Drug Designs --- Drug Modelings --- Modeling, Drug --- Modelings, Drug --- Drug Carrier --- Drug Delivery Systems --- Drug Targeting --- Delivery System, Drug --- Delivery Systems, Drug --- Drug Delivery System --- Drug Targetings --- System, Drug Delivery --- Systems, Drug Delivery --- Targeting, Drug --- Targetings, Drug --- Dosage Forms --- Delivery systems --- Pharmacotechnology. Preparations --- Computer-Aided Drug Design --- Computerized Drug Design --- Pharmaceutical Design --- Computer Aided Drug Design --- Computer-Aided Drug Designs --- Computerized Drug Designs --- Design, Computer-Aided Drug --- Design, Computerized Drug --- Design, Pharmaceutical --- Designs, Computer-Aided Drug --- Designs, Computerized Drug --- Designs, Pharmaceutical --- Drug Design, Computer-Aided --- Drug Design, Computerized --- Drug Designs, Computer-Aided --- Drug Designs, Computerized --- Pharmaceutical Designs --- farmacologie --- Magnetic Iron Oxide Nanoparticles

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This distinctive text provides a toolbox for pharmaceutical scientists and those involved in product development utilizing pulmonary drug delivery systems. Uniquely focusing on aspects of control, both temporal and spatial, the text collects a broad range of interlinked chapters that provide both theoretical and practical insight.   Controlled Pulmonary Drug Delivery begins by examination of the foundations for pulmonary drug delivery: the macro and microstructure of the airways, lung clearance, airway absorption and transport, aerosol physics, and a historical overview of the field. Unlike other texts, these chapters are written specifically with drug delivery in mind. The science and technology of inhaler devices, technologies, materials, and particles systems are covered. Testing methods and techniques are discussed before regulatory perspectives and performance specifications conclude the text. The twenty two novel chapters in this volume each provide a theoretical and practical set of tools that comprise a comprehensive toolbox.   This volume will be of interest to scientists and engineers developing pulmonary drug delivery systems. The unique themes of controlled release science and technology that run through the book ensure that experienced and newcomers will greatly benefit from this book. As the importance for control over therapeutic performance is better recognized and demanded, this text will be essential for those delivering bioactives to the lung. Dr. Hugh Smyth is Assistant Professor of Pharmaceutics at the University of Texas, Austin. He is a recipient of the Young Investigator in Pharmaceutics and Pharmaceutical Technology Award of the American Association of Pharmaceutical Scientists and has edited a volume on pulmonary drug delivery. Drs. Hickey and Smyth share a research interest in the delivery of drugs to the lungs for the treatment and prevention of a number of diseases. Dr. Anthony Hickey is Professor of Molecular Pharmaceutics and Biomedical Engineering at the University of North Carolina at Chapel Hill. He is a fellow of the Institute of Biology, American Association of Pharmaceutical Scientists and the American Association for the Advancement of Science. He has published several edited and authored volumes in the fields of pharmaceutical aerosols, process engineering and particulate science.

Drug delivery systems. --- Drug targeting. --- Technology, Pharmaceutical. --- Aerosol therapy --- Drug delivery systems --- Drug Administration Routes --- Colloids --- Biological Science Disciplines --- Respiratory System --- Respiratory Tract Diseases --- Chemicals and Drugs --- Therapeutics --- Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Dosage Forms --- Anatomy --- Natural Science Disciplines --- Complex Mixtures --- Specialty Uses of Chemicals --- Disciplines and Occupations --- Chemical Actions and Uses --- Aerosols --- Lung --- Physiology --- Administration, Inhalation --- Drug Delivery Systems --- Lung Diseases --- Pharmaceutical Preparations --- Drug Therapy --- Medicine --- Health & Biological Sciences --- Respiratory System Diseases --- Pharmacy, Therapeutics, & Pharmacology --- Lungs --- Diseases. --- Delivery systems, Drug --- Drug administration technology --- Drug delivery technology --- Drugs --- Pulmonary diseases --- Delivery systems --- Medicine. --- Pharmaceutical technology. --- Biomedicine. --- Biomedicine general. --- Pharmaceutical Sciences/Technology. --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Pharmaceutical technology --- Health Workforce --- Biomedicine, general.