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Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in mo

Cancer -- Cytopathology. --- Cancer -- Molecular aspects. --- Cancer - Treatment. --- Cancer -- Treatment -- Data processing. --- Cell differentiation. --- Cell Differentiation. --- Cells - Growth. --- Cellular therapy. --- Drug targeting. --- Growth factors - Therapeutic use. --- Intercellular Signaling Peptides and Proteins - metabolism. --- Metastasis. --- Neoplasms - etiology. --- Neoplasms - therapy. --- Growth factors --- Cancer --- Cellular therapy --- Cell differentiation --- Cells --- Metastasis --- Biological Factors --- Peptides --- Cell Physiological Processes --- Metabolic Phenomena --- Proteins --- Diseases --- Receptors, Peptide --- Amino Acids, Peptides, and Proteins --- Cell Physiological Phenomena --- Phenomena and Processes --- Chemicals and Drugs --- Receptors, Cell Surface --- Membrane Proteins --- Intercellular Signaling Peptides and Proteins --- Neoplasms --- Cell Differentiation --- Receptors, Growth Factor --- Metabolism --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Oncology --- Therapeutic use --- Treatment --- Growth --- Cell receptors --- Physiological effect. --- Treatment. --- Motility. --- Cell motility --- Cell movement --- Cellular movement --- Motility of cells --- Biomechanics --- Cell physiology --- Cancer therapy --- Cancer treatment --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Cell fate specification --- Cell specification --- Differentiation of cells --- Fate specification of cells --- Specification of cells --- Morphogenesis --- Movement --- Therapy --- Differentiation --- Fate specification --- Specification

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The ability to grow stem cells in the laboratory and to guide their maturation to functional cells allows us to study the underlying mechanisms that govern vasculature differentiation and assembly in health and disease. Accumulating evidence suggests that early stages of vascular growth are exquisitely tuned by biophysical cues from the microenvironment, yet the scientific understanding of such cellular environments is still in its infancy. Comprehending these processes sufficiently to manipulate them would pave the way to controlling blood vessel growth in therapeutic applications. This book assembles the works and views of experts from various disciplines to provide a unique perspective on how different aspects of its microenvironment regulate the differentiation and assembly of the vasculature. In particular, it describes recent efforts to exploit modern engineering techniques to study and manipulate various biophysical cues. Biophysical Regulation of Vascular Differentiation and Assembly provides an interdisciplinary view of vasculature regulation by various biophysical cues and presents recent advances in measuring and controlling such parameters. This book will be of interest to biologists, biophysicists and engineers who work with vascular differentiation and assembly.

Biomedical engineering. --- Biophysics. --- Blood-vessels -- Growth -- Regulation. --- Blood-vessels -- Growth. --- Cell differentiation. --- Neovascularization -- Regulation. --- Stem cells. --- Stem cells --- Blood-vessels --- Biophysics --- Biomedical engineering --- Neovascularization --- Cell differentiation --- Physics --- Engineering --- Cardiovascular System --- Cell Physiological Processes --- Biological Science Disciplines --- Cells --- Health Occupations --- Technology, Industry, and Agriculture --- Disciplines and Occupations --- Anatomy --- Natural Science Disciplines --- Cell Physiological Phenomena --- Technology, Industry, Agriculture --- Phenomena and Processes --- Biomedical Engineering --- Cell Differentiation --- Stem Cells --- Blood Vessels --- Biology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Physiology --- Cytology --- Growth --- Regulation --- Biological control systems. --- Growth. --- Biocybernetics --- Biofeedback --- Biological cybernetics --- Biological regulation --- Control biophysics --- Control systems, Biological --- Control theory in biology --- Regulation, Biological --- Biological physics --- Physics. --- Biological physics. --- Biophysics and Biological Physics. --- Biomedical Engineering. --- Stem Cells. --- Medical sciences --- Biological systems --- Control theory --- Cybernetics --- Feedback control systems --- Nervous system --- Biological and Medical Physics, Biophysics. --- Biomedical Engineering and Bioengineering. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Clinical engineering --- Medical engineering --- Bioengineering --- Medicine

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Darwin identified the existence of separate male and female gametes as one of the central mysteries of evolutionary biology. 150 years later, the question of why male gametes exist remains an intriguing puzzle. In this, the first book solely devoted to the evolution of anisogamy, top theorists in the field explore why gamete dimorphism characterizes nearly all plants and animals. Did separate male and female gametes evolve as a result of competition, or does anisogamy instead represent selection for cooperation? If disruptive selection drove the evolution of anisogamy, with male gametes focused on search and fusion, and female gametes provisioning the new zygote, why do some algal species continue to produce gametes of a single size? Does sperm limitation, or escape from infection, better explain the need for extremely small, highly mobile sperm? Written by leaders in the field, this volume offers an authoritative and cutting-edge overview of evolutionary theory.

Gametes --- Gametogenesis. --- Natural selection. --- Plants --- Reproduction, Asexual. --- Asexual reproduction --- Gemmation (Zoology) --- Spores --- Gemmation (Botany) --- Plant reproduction --- Plant physiology --- Reproduction --- Plants, Sex in --- Plant spores --- Darwinism --- Selection, Natural --- Genetics --- Variation (Biology) --- Biological invasions --- Evolution (Biology) --- Heredity --- Formation of gametes --- Cell differentiation --- Germ cells --- Evolution. --- Reproduction. --- Formation

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The discovery of adult neurogenesis caused a paradigm shift in the neurosciences. For more than 100 years, it was believed that adult neurons do not regenerate. Joseph Altman and Fernando Nottebohm found proof to the contrary and changed the course of history. Their research, included here, provides the foundations of the field. Today, adult neurogenesis is a rapidly expanding discipline applicable to the study of brain development and diseases, learning and memory, aging, and neuropsychiatric disorders. With multiple authors, the 27 chapters of this book contain the latest work in two volumes. The first presents the basic biology of adult neurogenesis in non-mammalian vertebrates and in the mammalian hippocampus and olfactory bulb, and the second discusses clinical implications and delves into adult neurogenesis and brain injury as well as neurodegenerative and neuropsychiatric pathologies. With details of the anatomy, physiology, and molecular biology of the two neurogenic brain regions, this book provides indispensable knowledge for many areas of neuroscience and for experimental and clinical applications of adult neurogenesis to brain therapy.

Brain. --- Developmental neurobiology. --- Neural stem cells. --- Neurons --- Brain --- Organogenesis --- Physiological Processes --- Cells --- Cell Differentiation --- Biological Science Disciplines --- Anatomy --- Embryonic and Fetal Development --- Natural Science Disciplines --- Physiological Phenomena --- Cell Physiological Processes --- Cell Physiological Phenomena --- Phenomena and Processes --- Reproduction --- Disciplines and Occupations --- Morphogenesis --- Reproductive Physiological Processes --- Reproductive Physiological Phenomena --- Reproductive and Urinary Physiological Phenomena --- Growth and Development --- Neurogenesis --- Nervous System --- Physiology --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Neuroscience --- Neurology --- Growth --- Cytology --- Molecular aspects --- Neurobiology. --- Developmental neurology --- Medicine. --- Neurosciences. --- Cell biology. --- Biomedicine. --- Cell Biology. --- Neurosciences --- Developmental biology --- Embryology --- Neurobiology --- Nervous system --- Neuroplasticity --- Evolution --- Cytology. --- Neural sciences --- Neurological sciences --- Medical sciences --- Cell biology --- Cellular biology --- Biology --- Cytologists

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Recent years have seen significant advancements in the development of enabling technologies that facilitate the study of Transcription Factors (TFs). TFs are pivotal in the regulation of plant development, reproduction, intercellular signaling, response to environment, cell cycle, and metabolism. Plant Transcription Factors: Methods and Protocols offers a comprehensive approach by covering the basic concepts as well as the detailed protocols of a series of commonly used tools for investigating plant TFs. From discussing select TF families in plants to presenting approaches for identifying them, methods are covered to verify the function, to identify protein interactions in which TFs are involved, and how the interactions are mediated. Increasing examples of TFs that function non-cell-autonomously are being discovered and methods to assess intercellular trafficking are also addressed. A section is devoted to examining interaction with DNA, and the volume concludes with a discussion of directed evolution to generate transcription factors that can more efficiently control desired processes. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.   Authoritative and accessible, Plant Transcription Factors: Methods and Protocols serves as an ideal guide to seasoned plant molecular biologists as well as scientists new to the field of TFs and provides many necessary methods to all scientists who are interested in exploring the functions of transcription factors. .

Plant genetic regulation --- Plant cell differentiation --- Genetic transcription --- Biology --- Proteins --- Eukaryota --- Amino Acids, Peptides, and Proteins --- Biological Science Disciplines --- Organisms --- Chemicals and Drugs --- Natural Science Disciplines --- Disciplines and Occupations --- Genetics --- Plants --- Plant Proteins --- Transcription Factors --- Botany --- Earth & Environmental Sciences --- Botany - General --- Plant Ecology --- Plantes --- Transcription génétique --- genetics --- Régulation génétique --- Cellules et tissus --- Différenciation --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Eucarya --- Eukarya --- Eukaryotes --- Eukaryotas --- Eukaryote --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Transcription (Genetics) --- Plant gene expression --- Transcription Factor --- Factor, Transcription --- Factors, Transcription --- Proteins, Plant --- Plant --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Regulation --- Transcription Factors. --- genetics. --- Botany. --- Plant genetics. --- Plant Sciences. --- Plant Genetics and Genomics. --- Botanical science --- Phytobiology --- Phytography --- Phytology --- Plant biology --- Plant science --- Natural history --- Floristic botany