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To date, there is a lack of available and effective therapeutic agents to treat bipolar depression. Patients suffering from resistant major depression reach a complete remission only in 35% of cases. The consequences of non-remission are significant for the patient (suicide, functional impairment). New treatment strategies are necessary in these two types of pathologies. Atypical neuroleptics seem to be very good candidates, thanks to their antidepressive and mood-stabilizing properties. The atypical neuroleptics concerned are olanzapine and quetiapine. Their antidepressive properties are obtained by various mechanisms, in particular by the antagonism of serotoninergic receptors 5-HT2A, dopamine D2 and a2-adrenergic. In bipolar depression, studies show that quetiapine has proved its effectiveness in monotherapy treatment, as well as olanzapine in combination with an antidepressant. These are well tolerated, and present no risk of precipitating a switch to mania. For resistant major depression, quetiapine or olanzapine in adjunct with an antidepressant was more effective than placebo but also more effective than an antidepressant monotherapy. Aripiprazole also shows some effectiveness. The significant unwanted effects of atypical neuroleptics have to be weighed up against the risks of a non-treated depression. Olanzapine and quetiapine’s risk/benefit balance seems to support their use in bipolar and resistant major depression A ce jour, les agents thérapeutiques disponibles pour traiter la dépression bipolaire sont peu nombreux et manquent d’efficacité. Les patients souffrant de dépression unipolaire résistante n’atteignent la rémission complète que dans 35% des cas. Les conséquences d’une non- rémission sont significatives pour le patient (suicide, impotence fonctionnelle,...). De nouvelles stratégies de traitement sont nécessaires dans ces deux types de pathologies. Les neuroleptiques atypiques semblent être de bons candidats, car ils possèdent des propriétés antidépressives et stabilisatrices de l’humeur. Les principaux neuroleptiques atypiques concernés sont l’olanzapine et la quétiapine. Leurs propriétés antidépressives sont obtenues par différents mécanismes, notamment par l’antagonisme sérotoninergique 5-HT2A, dopaminergique D2 et noradrénergique Œ2. Dans la dépression bipolaire, les études montrent que la quétiapine a fait ses preuves en monothérapie, ainsi que l’olanzapine en combinaison avec un antidépresseur, tout en montrant une bonne tolérance, sans risque de précipiter l’humeur vers la manie. Concernant la dépression unipolaire résistante, l’addition de la quétiapine ou de l’olanzapine à un antidépresseur a prouvé son efficacité, en comparaison à un placebo mais aussi à un antidépresseur seul. L’aripiprazole montre également une efficacité. Les effets indésirables non-négligeables des neuroleptiques sont à mettre en balance avec les risques d’une dépression non-traitée efficacement. La balance bénéfice/risque de l’olanzapine et de la quétiapine semble en faveur de leur utilisation dans la dépression bipolaire et unipolaire résistante

Bipolar Disorder --- Antipsychotic Agents --- Depressive Disorder, Major

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Bipolar disorder. --- Affective disorders --- Psychose maniacodépressive --- Troubles affectifs

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A biography of British writer Graham Greene which concentrates on how his life-long battle with Manic-depression disorder effected his writing.

Manic-depressive persons --- English --- Languages & Literatures --- English Literature --- Manic-depressive illness --- Manic-depressives --- Mentally ill --- Patients --- Greene, Graham, --- BD people (People with bipolar disorder) --- Bipolar disorder, People with --- Bipolar people --- People with bipolar affective psychosis --- People with bipolar depression --- People with bipolar mood disorder --- Depressed persons --- People with bipolar disorder.

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Mental disorders are prevalent and they have major consequences for those affected, including reduction in patients' social functioning and workplace productivity. The mainstays of treatment are various types of psychotropic drugs and conversational therapies. Dietary supplements, such as polyunsaturated fatty acids and vitamins, are sometimes used in the treatment of mental disorders, but their effect is debated. The present review aimed to answer: What is the effect of vitamins, minerals and other dietary supplements on mental health symptoms for people with ADHD (attention deficit hyperactivity disorder), anxiety disorders, bipolar disorder or depression? We completed an overview of recent systematic reviews (overview of reviews). Eleven systematic reviews were included, three of high methodological quality and eight of moderate methodological quality. The interventions included in the systematic reviews were polyunsaturated fatty acids, inositol, folate, and vitamin B-6. The findings were:1. We did not find any systematic reviews that included patients with anxiety disorders.2. It is unclear whether dietary supplements in the form of polyunsaturated fatty acids are effective in the treatment of mental disorders.3. The documentation was too limited to draw any conclusions about the effect of inositol, folate, and vitamin B-6.4. The documentation was too limited to draw any conclusions about adverse events from dietary supplements.5. Several of the systematic reviews were published more than six years ago.

Trace elements in nutrition. --- Anxiety disorders --- Depression, Mental --- Attention-deficit hyperactivity disorder --- Bipolar disorder --- Outcome assessment (Medical care) --- Treatment. --- Treatment. --- Treatment. --- Treatment.

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An impressive study that prompts the reader toward philosophical reflection on the hermeneutics of melancholy in its relation to maturing theological understanding and cultivation of a profound self-consciousness. Melancholy has been interpreted as a deadly sin or demonic temptation to non-being, yet its history of interpretation reveals a progressive coming to terms with the dark mood that ultimately unveils it as the self's own ground and a trace of the abysmal nature of God. The book advances two provocative claims: that far from being a contingent condition, melancholy has been progressive

Melancholy. --- Depression, Mental. --- Mélancolie --- Dépression --- Mélancolie --- Dépression --- Dejection --- Depression, Unipolar --- Depressive disorder --- Depressive psychoses --- Melancholia --- Mental depression --- Unipolar depression --- Affective disorders --- Neurasthenia --- Neuroses --- Manic-depressive illness --- Melancholy --- Sadness --- Emotions --- Depression, Mental --- Bipolar disorder