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Adhesive Interactions in Normal and Transformed Cells describes the basic mechanisms of the ability of tissue cells to attach to each other and to the extracellular matrix. These adhesive interactions are pivotal regulators of main cellular functions, such as proliferation, survival and migration. The adhesive interactions are involved in embryonic development, regeneration, and also in inflammation and degeneration processes, which are at the basis of many diseases. Serious alterations in cell adhesion caused by the oncogenic transformation play a key role in cancer invasion and metastasis. This volume provides comprehensive information about structural, mechanistic and signaling aspects of adhesive interactions in both normal and cancer cells in comparison. Integration of such aspects of the adhesive process as structure, relation to cell systems of receptors and cytoskeleton, function, signaling pathways, and the alterations in tumor cells constitutes the strongest point of this work. The results of the long-time author’s research are included in the book. The author was one of pioneers, who used scanning electron microscopy (SEM) to study the cell surface morphology of normal cultured cells and the cells underwent the oncogenic transformation, processes of their attachment to and spreading on the surfaces of a solid substratum, and also surprising ability of the cells to respond to various geometric configurations of the substrata surfaces. Adhesive Interactions in Normal and Transformed Cells has both biological and medical aspects and, therefore, it can be interesting not only for cell biologists, developmental biologists and cancer researchers, but also for physicians. It is intended for researchers, postdocs, undergraduate and graduate students.
Cell adhesion. --- Cell adhesion --- Cell Physiological Processes --- Cell Physiological Phenomena --- Phenomena and Processes --- Cell Adhesion --- Biology --- Health & Biological Sciences --- Biology - General --- Cytology --- Adherence, Cell --- Cell adherence --- Life sciences. --- Cancer research. --- Cell physiology. --- Life Sciences. --- Life Sciences, general. --- Cancer Research. --- Cell Physiology. --- Adhesion --- Cell interaction --- Membrane fusion --- Junctional complexes (Epithelium) --- Oncology. --- Cell function --- Physiology --- Tumors --- Biosciences --- Sciences, Life --- Science --- Cancer research
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Shotcrete --- Mine roof control. --- Ground control (Mining) --- Mine safety. --- Mine safety --- Adhesion --- Testing.
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Kevin Kosche zeigt eine umfassende Betrachtung der rechtshistorischen Entwicklung von Contra proferentem (Unklarheitenregel) sowie des aktuellen Status quo der Auslegungsregel im anglo-amerikanischen und kontinentaleuropäischen Recht. Die Analyse von Contra proferentem im heutigen Recht ist eingebettet in eine ausführliche und bisher in der deutschen Rechtsliteratur einzigartige Beschreibung der Methode der Vertragsauslegung im englischen und US-amerikanischen Recht. Im rechtsökonomischen Teil der Arbeit untersucht der Autor die Effizienz von Contra proferentem und des Transparenzgebots als Informationspflichten und Risikoverteilungsregeln. Er schließt mit einer detaillierten rechtshistorischen und rechtsvergleichenden Analyse der Entstehung des Transparenzgebots im deutschen Recht. Der Autor legt ein bisher verborgen gebliebenes Faktum des deutschen AGB-Rechts offen: das Transparenzgebot entwickelte sich unter dem prägendem Einfluss der culpa in contrahendo und entstammt ursprünglich der versicherungsrechtlichen Rechtsprechung der 20er und frühen 30er Jahre.
Adhesion contracts --- Standardized terms of contract --- Contracts --- Interpretation and construction --- Contracts, Standard --- Contracts, Uniform --- Standard conditions of contract --- Standard contracts --- Standardized contracts --- Uniform conditions of contract --- Uniform contracts --- Uniform terms of contract --- Contracts of adhesion --- Contracts - Interpretation and construction
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Adhesion plays a major role in the bacterial lifestyle. Bacteria can adhere to organic and inorganic surfaces, to each other, and of course to host cells during pathogenesis. The focus of this book is: how are such adhesion phenomena best studied? Microbial genetics experiments have greatly enhanced our knowledge of what bacterial factors are involved in adhesion. For numerous reasons, though, biochemical and structural biology knowledge of the molecular interactions involved in adhesion are limited. One major problem has been a lack of interdisciplinary research and understanding in the field. On the one hand, the microbiologists lack detailed knowledge of the biophysical possibilities and have limited access to the frequently expensive instrumentation involved while on the other hand, the experts in these methods frequently do not have access to the biological materials, nor do they necessarily understand the biological questions to be answered. The purpose of this book is thus to overcome this gap in communication between researchers in biology, chemistry and physics and to display the many ways and means to investigate bacterial adhesion. We hope to stimulate new and ground-breaking research.
Bacteria -- Adhesion. --- Bacterial Adhesion. --- Epithelial cells. --- Host-bacteria relationships. --- Pathogenic bacteria. --- Bacteria --- Bacterial Processes --- Bacterial Physiological Phenomena --- Microbiological Processes --- Microbiological Phenomena --- Phenomena and Processes --- Bacterial Adhesion --- Medicine --- Biology --- Health & Biological Sciences --- Medical Research --- Microbiology & Immunology --- Adhesion --- Host-parasite relationships. --- Adhesion. --- Physiology. --- Host-organism relationships --- Host-pathogen relationships --- Parasite-host relationships --- Pathogen-host relationships --- Relationships, Host-parasite --- Bacteria, Pathogenic --- Disease germs --- Bacterial physiology --- Bacterial adhesion --- Medicine. --- Medical microbiology. --- Proteins. --- Microbiology. --- Biophysics. --- Biological physics. --- Biomedicine. --- Biomedicine general. --- Biological Techniques. --- Medical Microbiology. --- Biophysics and Biological Physics. --- Protein Structure. --- Technique. --- Biological physics --- Medical sciences --- Physics --- Microbial biology --- Microorganisms --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Parasitism --- Pathogenic microorganisms --- Bacterial diseases --- Medical bacteriology --- Physiology --- Cell adhesion --- Cytology --- Biochemistry. --- Biological and Medical Physics, Biophysics. --- Research --- Methodology. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Composition --- Health Workforce --- Biology—Technique. --- Proteins . --- Biomedicine, general.
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The vascular endothelium lining the inner surface of blood vessels serves as the first interface for circulating blood components to interact with cells of the vascular wall and surrounding extravascular tissues. In addition to regulating blood delivery and perfusion, a major function of vascular endothelia, especially those in exchange microvessels (capillaries and postcapillary venules), is to provide a semipermeable barrier that controls blood-tissue exchange of fluids, nutrients, and metabolic wastes while preventing pathogens or harmful materials in the circulation from entering into tissues. During host defense against infection or tissue injury, endothelial barrier dysfunction occurs as a consequence as well as cause of inflammatory responses. Plasma leakage disturbs fluid homeostasis and impairs tissue oxygenation, a pathophysiological process contributing to multiple organ dysfunction associated with trauma, infection, metabolic disorder, and other forms of disease. In this book, we provide an updated overview of microvascular endothelial barrier structure and function in health and disease. The discussion is initiated with the basic physiological principles of fluid and solute transport across microvascular endothelium, followed by detailed information on endothelial cell-cell and cell-matrix interactions and the experimental techniques that are employed to measure endothelial permeability. Further discussion focuses on the signaling and molecular mechanisms of endothelial barrier responses to various stimulations or drugs, as well as their relevance to several common clinical conditions. Taken together, this book provides a comprehensive analysis of microvascular endothelial cell and molecular pathophysiology. Such information will assist scientists and clinicians in advanced basic and clinical research for improved health care.
Vascular endothelium. --- Blood Vessels --- Endothelium --- Epithelium --- Cardiovascular System --- Anatomy --- Tissues --- Endothelium, Vascular --- Human Anatomy & Physiology --- Health & Biological Sciences --- Physiology --- Capillaries --- Endothelium, Vascular. --- Capillary Permeability. --- Permeability. --- Microvascular permeability --- Endothelial barrier --- Cell-cell junction --- Cell-matrix adhesion --- Cytoskeleton --- Signal transduction
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European political parties have been recruiting members of over a century. However, 'parties without partisans' are conceivable today. Clearly, parties are changing, whether they are mutating, adapting or declining. In this context, it is crucial to understand the changes which affect party membership. It may indirectly affect the capacity of parties to perform their various functions in representative democraties. This book aims at contributing to three major topics related to the study of party membership. The first part of the book is dedicated to the analysis of the general trends in party membership across Europe in a comparative and long-term perspective. In the second part of the book, the contributions focus on the demand side, i.e. on parties and their assessment of membership, based on case studies. The final part of the book reverses the focus and examines party membership at the micro level (supply side), based on interviews and party membership surveys.
Political parties --- Political sociology --- Europe --- Party affiliation --- Political participation --- Partis politiques --- Participation politique --- Case studies --- Adhésion --- Cas, Etudes de --- Partis politiques et Union européenne --- Adhesion --- #SBIB:324H43 --- 324.24 --- Politieke structuren: politieke partijen --- Social sciences Political science Political parties Europe --- Political culture --- Adhésion --- Culture --- Political science --- Affiliation, Party --- Political affiliation --- Membership --- Partis politiques et Union européenne. --- Case studies. --- Political parties - Europe --- Political participation - Europe --- Party affiliation - Europe --- Partis politiques et Union européenne.
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De “Rechtskroniek voor Vrede- en Politierechters” beoogt ten behoeve van de Vrede- en Politierechters, hun plaatsvervangers en het personeel van hun griffies, een accurate, wetenschappelijk onderbouwde en praktisch gerichte toelichting te geven bij nieuwe wetten en ontwikkelingen in rechtspraak en rechtsleer. Volgende onderwerpen komen o.a. in dit boek aan bod: Het contentieux inzake de machtiging bij voorlopig bewind - De vergoedingsregeling voor voorlopige bewindvoerders - Het verhaalsrecht van de WAM-verzekeraar - De lasthebber ad hoc als vertegenwoordiger van de vervolgde rechtspersoon - De medische expertise over lichamelijke schade: tussen het recht op privacy van het slachtoffer, het recht op verdediging van de aansprakelijke en de plicht tot correcte vaststelling van de vergoeding door de rechter
Evidence, Expert --- Torts --- Traffic regulations --- Conciliation (Civil procedure) --- Capacity and disability --- Expertises --- Responsabilité civile --- Circulation --- Conciliation (Procédure civile) --- Incapacité (Droit) --- Droit --- Ebooks --- 347.764 <493> --- Verzekeringsrecht. Verzekeringen--België --- 347.764 <493> Verzekeringsrecht. Verzekeringen--België --- Responsabilité civile --- Conciliation (Procédure civile) --- Incapacité (Droit) --- Rechtsbronnen : Rechtspraak --- Sources du droit : Jurisprudence --- E-books --- Belgique --- Droit civil --- Procédure (droit) --- Médiation --- Représentation (droit) --- Mandat --- Droit pénal --- Peines --- Assurance --- Contrats d'adhésion --- Assurance-automobiles
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This volume presents material science and mechanical issues of hybrid adhesive bonds which are a combination of adhesive bonding and mechanical fastening, interference or welding. The hybrid concept includes also mixed-adhesive bonding, where at least two adhesives with different mechanical properties are placed along the bondline. The idea of hybrid joints is to gather the advantages of the different techniques leaving out their problems. Some of the advantages of these joints are a higher static and fatigue strength and a higher stiffness with respect to simple joints, a two-stage failure process and improved durability. The book treats all important kinds of hybrid joints which are in use today: weld – adhesive, rivet – adhesive, clinch – adhesive, bolt – adhesive, and adhesive – adhesive. A section dedicated to threadlocking and interference-fit adhesive joints is also included. All sections are treated from a scientific point of view with modeling issues supported by simple coupons testing and a technological point of view where the idea is to present more applied results with practical cases.
Adhesion -- Congresses. --- Adhesive joints. --- Mechanical Engineering --- Chemical & Materials Engineering --- Engineering & Applied Sciences --- Materials Science --- Mechanical Engineering - General --- Glued joints --- Materials science. --- Continuum mechanics. --- Tribology. --- Corrosion and anti-corrosives. --- Coatings. --- Materials Science. --- Tribology, Corrosion and Coatings. --- Continuum Mechanics and Mechanics of Materials. --- Joints (Engineering) --- Chemistry, inorganic. --- Mechanics. --- Mechanics, Applied. --- Solid Mechanics. --- Classical mechanics --- Newtonian mechanics --- Physics --- Dynamics --- Quantum theory --- Inorganic chemistry --- Chemistry --- Inorganic compounds --- Applied mechanics --- Engineering, Mechanical --- Engineering mathematics --- Surface coatings --- Materials --- Surfaces (Technology) --- Coating processes --- Thin films --- Anti-corrosive paint --- Atmospheric corrosion --- Metal corrosion --- Metals --- Rust --- Rustless coatings --- Chemical inhibitors --- Chemistry, Technical --- Fouling --- Weathering --- Paint --- Protective coatings --- Waterproofing --- Friction --- Corrosion --- Deterioration --- Surfaces
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"This book addresses the question of whether the drafting style of international contracts may actually achieve rendering the contract self-sufficient. The drafting style, including the recurrence of boilerplate clauses in all types of contracts and irrespective of the governing law, seems to aim at detaching the contract from any elements external to the contract itself, including the applicable law. This drafting style is originally based on the common law approach to contracts, but is now adopted in most international contracts even when they are not subject to a law belonging to the common law family.The analysis follows three different stages, each dealt with in a different part of the book"--Provided by publisher. "With the aim of creating an autonomous regime for the interpretation and application of the contract, boilerplate clauses are often inserted into international commercial contracts without negotiations or regard for their legal effects. The assumption that a sufficiently detailed and clear language will ensure that the legal effects of the contract will only be based on the contract, as opposed to the applicable law, was originally encouraged by English courts, and today most international contracts have these clauses, irrespective of the governing law. This collection of essays demonstrates that this assumption is not fully applicable under systems of civil law, because these systems are based on principles, such as good faith and loyalty, which contradict this approach"--Provided by publisher.
Standardized terms of contract. --- Contracts --- Foreign trade regulation. --- Contrats d'adhésion --- Contrats --- Commerce extérieur --- Language. --- Langage --- Réglementation --- Standardized terms of contract --- Foreign trade regulation --- Language --- 347.45 --- Export and import controls --- Foreign trade control --- Import and export controls --- International trade --- International trade control --- International trade regulation --- Prohibited exports and imports --- Trade regulation --- Agreements --- Contract law --- Contractual limitations --- Limitations, Contractual --- Commercial law --- Legal instruments --- Obligations (Law) --- Juristic acts --- Liberty of contract --- Third parties (Law) --- Contracts, Standard --- Contracts, Uniform --- Standard conditions of contract --- Standard contracts --- Standardized contracts --- Uniform conditions of contract --- Uniform contracts --- Uniform terms of contract --- Bijzondere overeenkomsten --(algemeen) --- Law and legislation --- 347.45 Bijzondere overeenkomsten --(algemeen) --- Contrats d'adhésion --- Commerce extérieur --- Réglementation --- Law --- General and Others --- Contracts - Language --- Droit
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Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.
Collagen. --- Connective Tissue. --- Connective tissues -- Congresses. --- Extracellular matrix. --- Polysaccharides. --- Extracellular Space --- Metalloendopeptidases --- Membrane Glycoproteins --- Antigens, Surface --- Proteins --- Amino Acids, Peptides, and Proteins --- Cellular Structures --- Endopeptidases --- Glycoproteins --- Membrane Proteins --- Antigens --- Metalloproteases --- Peptide Hydrolases --- Biological Factors --- Cells --- Chemicals and Drugs --- Hydrolases --- Anatomy --- Enzymes --- Enzymes and Coenzymes --- Cell Adhesion Molecules --- Extracellular Matrix --- Matrix Metalloproteinases --- Tissue Inhibitor of Metalloproteinases --- Biology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Cytology --- Physiology --- Cement substance (Anatomy) --- Ground substance (Anatomy) --- Ground substance (Histology) --- Intercellular matrix --- Interstitial substance --- Matrix, Extracellular --- Life sciences. --- Molecular biology. --- Biochemistry. --- Proteins. --- Cell biology. --- Life Sciences. --- Cell Biology. --- Biochemistry, general. --- Protein Science. --- Molecular Medicine. --- Connective tissues --- Extracellular space --- Cytology. --- Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Cell biology --- Cellular biology --- Cytologists --- Composition --- Health Workforce --- Proteins . --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Proteids --- Polypeptides --- Proteomics
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