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Neuroimaging has become a crucial technique for Neurosciences. Different structural, functional and neurochemical methods, developed in recent decades, have allowed a systematic investigation on the role of neural substrates involved in functions performed by the central nervous system, whether normal or pathological. This book includes contributions from the general area of the neuroimaging to the understanding of normal functions and abnormalities of the central nervous system.
Nervous system --- Degeneration. --- Degeneration, Nerve --- Nerve degeneration --- Nervous system degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Degeneration (Pathology) --- Degeneration and regeneration --- Radiology
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The Role of Histone Deacetylases in Neurodegenerative Diseases and Small-Molecule Inhibitors as a Potential Therapeutic Approach.- Phosphodiesterase Inhibition to Target the Synaptic Dysfunction in Alzheimer’s Disease.- Glutamate and Neurodegenerative Disease.- Modulation of the Kynurenine Pathway for the Potential Treatment of Neurodegenerative Diseases.- Spinal Muscular Atrophy: Current Therapeutic Strategies.
Nervous system -- Degeneration. --- Nervous system -- Diseases -- Treatment. --- Nervous System Diseases --- Diseases --- Neurodegenerative Diseases --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Nervous system --- Degeneration. --- Treatment. --- Degeneration, Nerve --- Nerve degeneration --- Nervous system degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Degeneration and regeneration --- Chemistry. --- Pharmacology. --- Medicinal chemistry. --- Neurology. --- Medicinal Chemistry. --- Pharmacology/Toxicology. --- Degeneration (Pathology) --- Biochemistry. --- Toxicology. --- Medicine --- Neuropsychiatry --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Composition --- Toxicology --- Neurology . --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Physiological effect
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Neurotraumatic (stroke, spinal cord trauma, and traumatic head injury) and neurodegenerative diseases (Alzheimer disease, Parkinson disease, Amyotrophic Lateral Sclerosis, Huntington disease, and prion disease) are afflicting aging Americans with increasing frequency. These diseases result in acute, as well as gradual and progressive neurodegeneration, leading to brain dysfunction. Known risk factors for stroke and neurodegenerative diseases include increasing age, genetic polymorphisms, endocrine dysfunction, oxidative stress, neuroinflammation, excitotoxicity, infection, and exposure to neurotoxins. In contrast, spinal cord trauma and traumatic brain injury due to motorcycle and car accidents are major causes of death and disability among young people below the mid-thirties. Although molecular mechanisms involved in the pathogenesis of neurotraumatic and neurodegenerative diseases remain elusive, oxidative stress, excitotoxicity, inflammation, misfolding, aggregation, and accumulation of proteins, perturbed Ca2+ homeostasis, and apoptosis have been implicated as possible causes of neurodegeneration in the above neurological disorders. In 2005, the global prevalence of neurotraumatic and neurodegenerative diseases was estimated at 35 million, with more than seven million new cases occurring each year. It is calculated that the number of people affected with neurotraumatic and neurodegenerative diseases will double every 20 years, to 100 million by 2040, if a cure is not discovered. More than 60% of dementia cases are due to Alzheimer disease. Today, approximately six million individuals in the US suffer from Alzheimer disease alone, representing one in eight individuals over the age of 65-70. Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases presents readers with a cutting edge and comprehensive overview of neurochemical aspects of neurotraumatic and neurodegenerative diseases and their potential therapeutic strategies in a manner that is useful not only to graduate students and teachers, but also to research scientists and clinicians. About the Author: Dr. Akhlaq A. Farooqui is a leader in the field of brain phospholipases, lipid mediators, glutamate neurotoxicity and neurological disorders. Dr. Farooqui has authored five monographs: Glycerophospholipids in Brain: Phospholipase A2 in Neurological Disorders (2007); Neurochemical Aspects of Excitotoxicity (2008); Metabolism and Functions of Bioactive Ether Lipids in Brain (2008); Hot Topics in Neural Membrane Lipidology (2009), and Beneficial Effects of Fish Oil on Human Brain (2009). All monographs are published by Springer. Dr. Farooqui has also edited two books: Biogenic Amines: Pharmacological, Neurochemical and Molecular Aspects in the CNS Nova Science Publishers, Hauppauge, N.Y (2010) and Molecular Aspects of Neurodegeneration and Neuroprotection, Bentham Science Publishers Ltd (2010).
Nervous system -- Degeneration. --- Nervous system --- Brain --- Spinal cord --- Neurochemistry --- Brain Diseases --- Nervous System Diseases --- Natural Science Disciplines --- Wounds and Injuries --- Trauma, Nervous System --- Craniocerebral Trauma --- Nervous System --- Spinal Cord Diseases --- Diseases --- Central Nervous System Diseases --- Disciplines and Occupations --- Anatomy --- Brain Injuries --- Central Nervous System --- Spinal Cord Injuries --- Neurodegenerative Diseases --- Chemistry --- Medicine --- Health & Biological Sciences --- Neurology --- Degeneration --- Wounds and injuries --- Neurochemistry. --- Degeneration. --- Degeneration, Nerve --- Nerve degeneration --- Nervous system degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Degeneration and regeneration --- Medicine. --- Neurosciences. --- Neurology. --- Biomedicine. --- Biochemistry --- Neurosciences --- Degeneration (Pathology) --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Neurology .
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Huntington''s chorea. --- Huntington's disease --- Dementia --- Heredodegenerative Disorders, Nervous System --- Cognition Disorders --- Biology --- Chorea --- Basal Ganglia Diseases --- Brain Diseases --- Delirium, Dementia, Amnestic, Cognitive Disorders --- Genetic Diseases, Inborn --- Neurodegenerative Diseases --- Biological Science Disciplines --- Dyskinesias --- Mental Disorders --- Central Nervous System Diseases --- Natural Science Disciplines --- Movement Disorders --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Nervous System Diseases --- Psychiatry and Psychology --- Disciplines and Occupations --- Diseases --- Huntington Disease --- Genetics --- Medicine --- Health & Biological Sciences --- Neurology --- Genetic Diseases --- Genetic Disorders --- Hereditary Disease --- Inborn Genetic Diseases --- Single-Gene Defects --- Hereditary Diseases --- Defect, Single-Gene --- Defects, Single-Gene --- Disease, Genetic --- Disease, Hereditary --- Disease, Inborn Genetic --- Diseases, Genetic --- Diseases, Hereditary --- Diseases, Inborn Genetic --- Disorder, Genetic --- Disorders, Genetic --- Genetic Disease --- Genetic Disease, Inborn --- Genetic Disorder --- Inborn Genetic Disease --- Single Gene Defects --- Single-Gene Defect --- Genetics, Medical --- Nonpsychotic Organic Brain Syndrome --- Clerambault Syndrome --- Kandinsky Syndrome --- Mental Disorders, Organic --- Organic Brain Syndrome, Nonpsychotic --- Organic Mental Disorders --- Organic Mental Disorders, Psychotic --- Psychoses, Traumatic --- Disorder, Neurocognitive --- Disorders, Neurocognitive --- Disorders, Organic Mental --- Mental Disorder, Organic --- Neurocognitive Disorder --- Organic Mental Disorder --- Traumatic Psychoses --- Brain Disorders --- CNS Disorders, Intracranial --- Central Nervous System Disorders, Intracranial --- Central Nervous System Intracranial Disorders --- Encephalon Diseases --- Encephalopathy --- Intracranial CNS Disorders --- Intracranial Central Nervous System Disorders --- Brain Disease --- Brain Disorder --- CNS Disorder, Intracranial --- Encephalon Disease --- Encephalopathies --- Intracranial CNS Disorder --- Basal Ganglia Disorders --- Lenticulostriate Disorders --- Extrapyramidal Disorders --- Basal Ganglia Disease --- Basal Ganglia Disorder --- Extrapyramidal Disorder --- Lenticulostriate Disorder --- Chorea Disorders --- Chorea Syndromes --- Chorea, Benign Hereditary --- Chorea, Chronic Progressive --- Chorea, Rheumatic --- Chorea, Senile --- Chorea, Sydenham --- Choreatic Syndromes --- Choreic Movement --- Dyskinesias, Paroxysmal --- Hereditary Chorea --- Hereditary Progressive Chorea Without Dementia --- Paroxysmal Dyskinesias --- Rheumatic Chorea --- Senile Chorea --- St. Vitus's Dance --- Sydenham Chorea --- Sydenham's Chorea --- Choreatic Disorders --- Choreiform Movement --- Benign Hereditary Chorea --- Benign Hereditary Choreas --- Chorea Disorder --- Chorea Syndrome --- Chorea, Hereditary --- Chorea, Sydenham's --- Choreas --- Choreas, Benign Hereditary --- Choreas, Chronic Progressive --- Choreas, Hereditary --- Choreas, Rheumatic --- Choreas, Senile --- Choreas, Sydenham --- Choreatic Disorder --- Choreatic Syndrome --- Choreic Movements --- Choreiform Movements --- Chronic Progressive Chorea --- Chronic Progressive Choreas --- Disorder, Chorea --- Disorder, Choreatic --- Disorders, Chorea --- Disorders, Choreatic --- Dyskinesia, Paroxysmal --- Hereditary Chorea, Benign --- Hereditary Choreas --- Hereditary Choreas, Benign --- Movement, Choreic --- Movement, Choreiform --- Movements, Choreic --- Movements, Choreiform --- Paroxysmal Dyskinesia --- Progressive Chorea, Chronic --- Progressive Choreas, Chronic --- Rheumatic Choreas --- Senile Choreas --- St. Vitus Dance --- St. Vitus's Dances --- St. Vituss Dance --- Sydenham Choreas --- Sydenhams Chorea --- Syndrome, Chorea --- Syndrome, Choreatic --- Syndromes, Chorea --- Syndromes, Choreatic --- Overinclusion --- Disorder, Cognition --- Disorders, Cognition --- Cognitive Aging --- Degenerative Hereditary Diseases, Nervous System --- Hereditary Neurodegenerative Diseases --- Hereditary-Degenerative Disorders, Nervous System --- Nervous System Degenerative Hereditary Diseases --- Nervous System Hereditary Degenerative Diseases --- Degenerative Disease, Nervous System, Hereditary --- Degenerative Hereditary Disorders, Nervous System --- Hereditary Diseases, Neurodegenerative --- Nervous System Diseases, Degenerative, Hereditary --- Neurodegenerative Diseases, Hereditary --- Disease, Hereditary Neurodegenerative --- Disease, Neurodegenerative Hereditary --- Diseases, Hereditary Neurodegenerative --- Diseases, Neurodegenerative Hereditary --- Hereditary Degenerative Disorders, Nervous System --- Hereditary Disease, Neurodegenerative --- Hereditary Neurodegenerative Disease --- Neurodegenerative Disease, Hereditary --- Neurodegenerative Hereditary Disease --- Neurodegenerative Hereditary Diseases --- Amentia --- Familial Dementia --- Senile Paranoid Dementia --- Amentias --- Dementia, Familial --- Dementias --- Dementias, Familial --- Dementias, Senile Paranoid --- Familial Dementias --- Paranoid Dementia, Senile --- Paranoid Dementias, Senile --- Senile Paranoid Dementias --- Tauopathies --- Genetic Structures --- Genetic Phenomena --- Akinetic-Rigid Variant of Huntington Disease --- Chorea, Chronic Progressive Hereditary (Huntington) --- Chronic Progressive Hereditary Chorea (Huntington) --- Huntington Chronic Progressive Hereditary Chorea --- Huntington Disease, Akinetic-Rigid Variant --- Huntington Disease, Juvenile --- Huntington Disease, Juvenile-Onset --- Huntington Disease, Late Onset --- Huntington's Chorea --- Huntington's Disease --- Juvenile-Onset Huntington Disease --- Late-Onset Huntington Disease --- Progressive Chorea, Chronic Hereditary (Huntington) --- Progressive Chorea, Hereditary, Chronic (Huntington) --- Huntington Chorea --- Juvenile Huntington Disease --- Akinetic Rigid Variant of Huntington Disease --- Chorea, Huntington --- Chorea, Huntington's --- Huntington Disease, Akinetic Rigid Variant --- Huntington Disease, Juvenile Onset --- Huntington Disease, Late-Onset --- Juvenile Onset Huntington Disease --- Late Onset Huntington Disease --- Nervous System Disorders --- Neurological Disorders --- Neurologic Disorders --- Disease, Nervous System --- Diseases, Nervous System --- Disorder, Nervous System --- Disorder, Neurologic --- Disorder, Neurological --- Disorders, Nervous System --- Disorders, Neurologic --- Disorders, Neurological --- Nervous System Disease --- Nervous System Disorder --- Neurologic Disorder --- Neurological Disorder --- Disorders, Congenital --- Congenital Disorders --- Neonatal Diseases and Abnormalities --- Congenital Disorder --- Disorder, Congenital --- Movement Disorder Syndromes --- Dyskinesia Syndromes --- Etat Marbre --- Status Marmoratus --- Dyskinesia Syndrome --- Movement Disorder --- Movement Disorder Syndrome --- Psychomotor Disorders --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- CNS Diseases --- Central Nervous System Disorders --- CNS Disease --- Central Nervous System Disease --- Central Nervous System Disorder --- Behavior Disorders --- Diagnosis, Psychiatric --- Mental Disorders, Severe --- Psychiatric Diagnosis --- Mental Illness --- Psychiatric Diseases --- Psychiatric Disorders --- Psychiatric Illness --- Illness, Mental --- Mental Disorder --- Mental Disorder, Severe --- Mental Illnesses --- Psychiatric Disease --- Psychiatric Disorder --- Psychiatric Illnesses --- Severe Mental Disorder --- Severe Mental Disorders --- Mentally Ill Persons --- Abnormal Movements --- Hemiballism --- Linguofacial Dyskinesia --- Oral Dyskinesia --- Oral-Facial Dyskinesia --- Tardive Oral Dyskinesia --- Asterixis --- Ballismus --- Hemiballismus --- Involuntary Movements --- Lingual-Facial-Buccal Dyskinesia --- Orofacial Dyskinesia --- Abnormal Movement --- Dyskinesia --- Dyskinesia, Lingual-Facial-Buccal --- Dyskinesia, Linguofacial --- Dyskinesia, Oral --- Dyskinesia, Oral-Facial --- Dyskinesia, Orofacial --- Dyskinesias, Lingual-Facial-Buccal --- Dyskinesias, Linguofacial --- Dyskinesias, Oral --- Dyskinesias, Oral-Facial --- Dyskinesias, Orofacial --- Involuntary Movement --- Lingual Facial Buccal Dyskinesia --- Lingual-Facial-Buccal Dyskinesias --- Linguofacial Dyskinesias --- Movement, Abnormal --- Movement, Involuntary --- Movements, Abnormal --- Movements, Involuntary --- Oral Dyskinesias --- Oral Facial Dyskinesia --- Oral-Facial Dyskinesias --- Orofacial Dyskinesias --- Tardive Oral Dyskinesias --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Degenerative Diseases, Central Nervous System --- Degenerative Diseases, Neurologic --- Degenerative Diseases, Spinal Cord --- Degenerative Neurologic Diseases --- Degenerative Neurologic Disorders --- Nervous System Degenerative Diseases --- Neurodegenerative Disorders --- Neurologic Degenerative Conditions --- Neurologic Degenerative Diseases --- Neurologic Diseases, Degenerative --- Degenerative Diseases, Nervous System --- Degenerative Condition, Neurologic --- Degenerative Conditions, Neurologic --- Degenerative Neurologic Disease --- Degenerative Neurologic Disorder --- Neurodegenerative Disease --- Neurodegenerative Disorder --- Neurologic Degenerative Condition --- Neurologic Degenerative Disease --- Neurologic Disease, Degenerative --- Neurologic Disorder, Degenerative --- Neurologic Disorders, Degenerative --- Chronic progressive chorea --- Chronic progressive hereditary chorea --- Degenerative chorea --- HC (Disease) --- HD (Disease) --- Hereditary chorea --- Huntington chorea --- Huntington chronic progressive hereditary chorea --- Huntington disease --- Huntington's chorea --- Lund-Huntington chorea --- Microcellular striatal syndrome --- Progressive hereditary chorea, Chronic --- Genetic disorders --- Nervous system --- Degeneration --- United States --- China --- Relations --- Foreign economic relations. --- genetics. --- therapy.
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