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Music --- anno 1600-1699 --- Europe --- Musique --- Manuscripts --- Manuscrits --- Uppsala universitet. --- Dissemination of music --- History

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The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane which serves as a gas exchange surface and its function is supported by a dense capillary network. Because of its extensive vascularization and easy accessibility, the CAM has been broadly used to study the morpho-functional aspects of the angiogenesis process in vivo and to investigate the efficacy and mechanisms of action of pro-angiogenic and anti-angiogenic natural and synthetic molecules. The CAM is a suitable site for transplanting tissues, which can survive and develop in the CAM by peripheral anastomoses between graft and original CAM vasculature or by new angiogenic vessels grown from the CAM that invade the graft. While the formation of peripheral anastomoses between host and pre-existing donor vessels is the main, and the most common, mechanism involved in the revascularization of embryonic grafts, the growth of CAM-derived vessels into the graft is only stimulated in tumor grafts. The CAM has long been a favored system for the study of tumor angiogenesis and metastasis, because at this stage the chick immunocompetence system is not fully developed and the conditions for rejection have not been established. Tumors remain avascular for 72 h, after which they are penetrated by new blood vessels and begin a phase of rapid growth. Also, delivery of tumor cells onto the CAM allows the fine study of the effects of tumor derived angiogenic growth factors on blood vessel structure and functionality. The CAM may also used to verify the ability to inhibit the growth of capillaries by implanting tumors onto the CAM and by comparing tumor growth and vascularization with or without the administration of an anti-angiogenic molecule. Other studies using the tumor cells/CAM model have focused on the invasion of the chorionic epithelium and the blood vessels by tumor cells. The cells invade the epithelium and the mesenchymal connective tissue below, where they are found in the form of a dense bed of blood vessels, which is a target for intravasation.

Chickens -- Embryos. --- Metastasis -- Animal models. --- Metastasis. --- Neovascularization -- Animal models. --- Neovascularization. --- Neovascularization --- Metastasis --- Chickens --- Medicine --- Human Anatomy & Physiology --- Oncology --- Physiology --- Health & Biological Sciences --- Animal models --- Embryos --- Cancer --- Cancer metastasis --- Dissemination of cancer --- Metastases --- Metastatic cancer --- Neoplasm metastasis --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Angiogenesis --- Dissemination --- Medicine. --- Cancer research. --- Oncology. --- Pathology. --- Cell biology. --- Biomedicine. --- Cancer Research. --- Cell Biology. --- Pathology --- Cancer invasiveness --- Cancer of unknown primary origin --- Blood-vessels --- Growth --- Oncology  . --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Tumors --- Cancer research

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Colorectal cancer is the third most common cancer worldwide, and in many parts of the western world, it is the second leading cause of cancer-related deaths. This book covers colon cancer metastasis from the most fundamental aspects to clinical practice. Major topics include physiopathology, genetic and epigenetic controls, cancer initiating cells, epithelial-mesenchymal transition, growth factors and signalling, cell adhesion, natures of liver metastasis, angiogenesis and lymphangiogenesis, inflammatory response, prognostic markers, sentinel node and staging, and finally diagnosis and treatment. Each chapter has been contributed by leaders in the field. A key feature is that it connects with a large readership including students, fundamentalists and clinicians. Another specific feature of the book is that the chapters are written in a didactic and illustrative fashion. These characteristics coupled with the choice of the topics and authors, makes this book a reference in the field. It represents an essential acquisition for medical libraries, clinicians as well as medical and graduate students.

Colon (Anatomy) -- Cancer. --- Metastasis. --- Rectum -- Cancer. --- Colon (Anatomy) --- Rectum --- Metastasis --- Intestinal Neoplasms --- Neoplastic Processes --- Rectal Diseases --- Colonic Diseases --- Neoplasms --- Intestinal Diseases --- Gastrointestinal Neoplasms --- Pathologic Processes --- Colorectal Neoplasms --- Neoplasm Metastasis --- Digestive System Neoplasms --- Diseases --- Gastrointestinal Diseases --- Pathological Conditions, Signs and Symptoms --- Neoplasms by Site --- Digestive System Diseases --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Cancer. --- Cancer metastasis --- Dissemination of cancer --- Metastases --- Metastatic cancer --- Neoplasm metastasis --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Colorectal cancer --- Rectal cancer --- Colon cancer --- Dissemination --- Medicine. --- Cancer research. --- Antibodies. --- Molecular biology. --- Oncology. --- Pathology. --- Biomedicine. --- Cancer Research. --- Molecular Medicine. --- Pathology --- Cancer invasiveness --- Cancer of unknown primary origin --- Oncology  . --- Monoclonal antibodies. --- Disease (Pathology) --- Medical sciences --- Medicine, Preventive --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Immunoglobulins --- Molecular cloning --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Physicians --- Tumors --- Health Workforce --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research --- Biology --- Immunospecificity. --- Cancer Biology. --- Biomedical Research. --- Adaptive Immunity. --- Research. --- Immunological specifics --- Serological specificity --- Specificity (Immunology) --- Antigenic determinants --- Binding sites (Biochemistry) --- Immune recognition --- Biological research --- Biomedical research --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors

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Solid tumors frequently contain areas of oxygen deprivation (hypoxia) due to rapid cell proliferation and/or vascular insufficiency. The presence of hypoxic domains typically correlates with poor patient prognosis, due to the relative resistance of hypoxic cells to conventional cancer therapies and effects of O2 availability on disease progression. The response of malignant cells to hypoxia has been the focus of intense research over the last decade. In this issue of Current Topics in Microbiology and Immunology, the authors present articles describing the impact of hypoxia on components of the tumor microenvironment (such as endothelial cells, inflammatory cells, and tumor associated fibroblasts), the expression of unique microRNAs, tumor cell differentiation status, and metastasis. Each review article describes the state of the field studying these topics, and poses important questions for the future. The overall goal is to depict tumor phenotypes and associated molecular pathways to be exploited in the development of novel therapeutics to be used against a broad spectrum of human cancers.

Anoxemia. --- Cancer -- Genetic aspects. --- Metastasis. --- Tumors -- Growth. --- Anoxemia --- Carcinogenesis --- Tumors --- Oxygen --- Tissue respiration --- Metastasis --- Chalcogens --- Diseases --- Signs and Symptoms, Respiratory --- Neoplastic Processes --- Biological Science Disciplines --- Gases --- Signs and Symptoms --- Natural Science Disciplines --- Inorganic Chemicals --- Pathologic Processes --- Elements --- Anoxia --- Neoplasm Metastasis --- Neoplasms --- Physiology --- Pathological Conditions, Signs and Symptoms --- Disciplines and Occupations --- Chemicals and Drugs --- Medicine --- Biology --- Health & Biological Sciences --- Oncology --- Microbiology & Immunology --- Internal Medicine --- Pathophysiology --- Physiological effect --- Physiological aspects --- Physiological transport --- Cancer invasiveness. --- Oxygen in the body. --- Pathophysiology. --- Growth. --- Physiological transport. --- Delivery of oxygen (Physiology) --- Oxygen delivery (Physiology) --- Oxygen transport (Physiology) --- Cancer --- Neoplasm growth --- Tumor growth --- Dissemination of cancer --- Invasiveness (Oncology) --- Neoplasm invasiveness --- Spread of cancer --- Tumor dissemination --- Tumor invasiveness --- Tumor progression --- Tumor spread --- Anoxaemia --- Anoxhemia --- Hypoxemia --- Hypoxia (Hematology) --- Oxygen deficiency in the blood --- Growth --- Medicine. --- Cancer research. --- Human physiology. --- Embryology. --- Biomedicine. --- Cancer Research. --- Human Physiology. --- Animal embryology --- Animals --- Development, Embryological --- Development, Embryonic --- Development, Zygotic --- Embryogenesis --- Embryogeny --- Embryological development --- Embryonic development --- Zoology --- Zygote development --- Zygotes --- Zygotic development --- Zygotic embryogenesis --- Developmental biology --- Morphology (Animals) --- Embryos --- Reproduction --- Human biology --- Medical sciences --- Human body --- Cancer research --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Embryology --- Development --- Body composition --- Cancer cells --- Altitude, Influence of --- Asphyxia --- Oxygen in the body --- Oncology.