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Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer.

Cancer --Genetic aspects. --- Polyploidy. --- Cancer --- Polyploidy --- Chromosome Aberrations --- Biology --- Ploidies --- Gene Expression Regulation --- Genomic Instability --- Diseases --- Pathologic Processes --- Genetic Phenomena --- Biological Science Disciplines --- Mutation --- Genetic Processes --- Phenomena and Processes --- Natural Science Disciplines --- Genetic Variation --- Pathological Conditions, Signs and Symptoms --- Disciplines and Occupations --- Chromosomal Instability --- Neoplasms --- Gene Expression Regulation, Neoplastic --- Genetics --- Medicine --- Health & Biological Sciences --- Oncology --- Genetic aspects --- Genetic aspects. --- Cancer genetics --- Medicine. --- Biomedicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Chromosome numbers --- Cancer genes --- Health Workforce --- Biomedicine, general.

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Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting ‘bottlenecks’ in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations. This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader.

Cancer -- Genetic aspects. --- Chromosome abnormalities. --- Human genetics. --- Medical genetics. --- Molecular genetics. --- Mutation (Biology). --- Mutation (Biology) --- Chromosome abnormalities --- Cancer --- Genetics --- DNA Repair --- Genomic Instability --- Chromosome Aberrations --- Neoplasms --- Diseases --- Mutation --- Pathologic Processes --- Genetic Phenomena --- Biochemical Processes --- Genetic Processes --- Biology --- Biological Science Disciplines --- Genetic Variation --- Chemical Processes --- Phenomena and Processes --- Biochemical Phenomena --- Pathological Conditions, Signs and Symptoms --- Natural Science Disciplines --- Chemical Phenomena --- Disciplines and Occupations --- Pathology --- Cytology --- Medicine --- Health & Biological Sciences --- Genetic aspects --- Genetic aspects. --- Cancer genetics --- Chromosomal aberrations --- Chromosome anomalies --- Medicine. --- Cancer research. --- Cytogenetics. --- Laboratory medicine. --- Oncology. --- Cell biology. --- Biomedicine. --- Human Genetics. --- Laboratory Medicine. --- Cancer Research. --- Cell Biology. --- Cancer genes --- Chromosomes --- Karyotypes --- Variation (Biology) --- Oncology  . --- Medical laboratories. --- Cytology. --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Tumors --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Heredity, Human --- Human biology --- Physical anthropology --- Cancer research --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Cancer. --- Medical Genetics. --- Biomedical Research. --- Molecular Genetics. --- Cancer Biology. --- Research. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Molecular biology --- Biological research --- Biomedical research --- Health Workforce --- Clinical genetics --- Heredity of disease --- Human genetics --- Medical sciences --- Genetic disorders