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This volume of Methods in Enzymology covers the current methodology for the detection and assessment of constitutively active proteins. The chapters written by expert authors who are leaders in the field, provide hints and tricks not available in primary research publications.It is extensively referenced, with useful figures and tables throughout the volume. A. Expert authors who are leaders in the field B. Extensively referenced and useful figures and tables C. Provides hints and tricks to facilitate reproduction of methods

Proteins. --- Cell receptors. --- Cellular signal transduction. --- G proteins. --- Phosphotransferases (Alcohol Group Acceptor) --- Membrane Proteins --- Amino Acids, Peptides, and Proteins --- Phosphotransferases --- Chemicals and Drugs --- Transferases --- Enzymes --- Enzymes and Coenzymes --- Proteins --- Protein Kinases --- Receptors, G-Protein-Coupled --- Receptors, Cell Surface --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Proteids --- Binding sites (Biochemistry) --- Cell membranes --- Biomolecules --- Polypeptides --- Proteomics

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This book presents a significant and up-to-date review of various recognition receptors, their immobilization, and an overview of surface characterization techniques. Distinguished scientists from key institutions worldwide have contributed chapters that provide a deep analysis of their particular subjects; at the same time, each topic is framed within the context of this integrated approach. This work explores comprehensively the field of recognition receptors, presenting a thorough review of the subject and effective integration of these receptors on sensor surfaces in order to appropriately convey state-of the-art fundamentals and applications of the most innovative approaches. The book consists of four parts: The first part comprises three chapters, which are devoted to the introduction of biomolecular recognition, surface sensitization and recognition receptors immobilization, as well as containing an overview of the analytical tools that can be used for surface characterization. The second part describes the different natural recognition receptors (enzymes, antibodies, cells, tissues, plant tissues, peptides, bacteriophages and photosynthetic proteins) currently used in the field of biosensors and microarrays. It covers the theory behind each technique and delivers a detailed state-of-the-art review for each new technology. The third part covers the recognition receptors that can be prepared and tailored by man to mimic natural molecules used in biosensors and microarrays. It describes in detail the use of engineered antibodies, carbohydrates, nucleic acids, oligonucleotides, aptamers, genetically engineered cells, genetically engineered proteins, phage display, molecularly imprinted polymers, and biomemetic materials as recognition elements. The fourth part contains one chapter that briefly covers the kinetics and thermodynamics of association/dissociation of analytes to the recognition receptors on sensor surfaces. Students and researchers who need a solid foundation or reference, and practitioners interested in discovering more about what is state-of-the-art in the field of recognition receptors will find this book invaluable. This book is written for academics, from undergraduate and postgraduate students upward, working in areas related to chemical/bio-sensors. It would be an important reference for, but not limited to, professionals working in varied fields including biology, biotechnology, biochemistry, analytical chemistry, biomedicine, physical chemistry, microsystem engineering, nanotechnology, veterinary, food QA, bioterrorism and security, as well as health surveillance. The book has more than 150 illustrations and figures to help explain and clarify the ideas presented.

Biomedical engineering. --- Bioorganic chemistry. --- Biosensors. --- Cell receptors. --- Engineering. --- Microbiology. --- Nanotechnology. --- Biosensors --- Cell receptors --- Membrane Proteins --- Investigative Techniques --- Molecular Probe Techniques --- Biosensing Techniques --- Methods --- Receptors, Cell Surface --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Health & Biological Sciences --- Biomedical Engineering --- Biodetectors --- Biological detectors --- Biological sensors --- Biomedical detectors --- Biomedical sensors --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Biophysics. --- Biological physics. --- Biomedical Engineering. --- Biophysics and Biological Physics. --- Bioorganic Chemistry. --- Detectors --- Medical instruments and apparatus --- Physiological apparatus --- Binding sites (Biochemistry) --- Cell membranes --- Biomedical Engineering and Bioengineering. --- Biological and Medical Physics, Biophysics. --- Molecular technology --- Nanoscale technology --- High technology --- Microbial biology --- Biology --- Microorganisms --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Bio-organic chemistry --- Biological organic chemistry --- Biochemistry --- Chemistry, Organic --- Biological physics --- Medical sciences --- Physics

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The poor prognosis and high mortality for cancer patients are majorly ascribed to tumor metastasis, one of the most complicated pathological processes. Elucidation of molecular mechanisms for metastasis is essential for management and prevention of this lethal condition. In the book to be published, we take comprehensive review in regard with the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. Specifically, the initial stage of tumor metastasis will be highlighted. The complex tumor microenvironment accumulate a lot of growth factors, inflammatory cytokines and extracellular matrix which may turn into a group of potent metastatic factors. An integrated and sustained signaling induced by these metastatic factors may trigger EMT, migration and invasion of primary tumor into surround tissue. Blokcade of these signal pathways is the most effective approach for prevention of tumor metastasis. A lot of clinical trials are under way for this purpose and the outcome are promising. The expert reviews compiled in this book may encourage the researcher in this exciting field for future study.

Cellular signal transduction. --- Metastasis. --- Metastasis --- Cellular signal transduction --- Biochemical Processes --- Cell Physiological Processes --- Biological Science Disciplines --- Neoplastic Processes --- Natural Science Disciplines --- Biochemical Phenomena --- Neoplasms --- Cell Physiological Phenomena --- Pathologic Processes --- Chemical Processes --- Neoplasm Metastasis --- Signal Transduction --- Physiology --- Chemical Phenomena --- Disciplines and Occupations --- Diseases --- Phenomena and Processes --- Pathological Conditions, Signs and Symptoms --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Carcinogenesis --- Research. --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Cancer metastasis --- Dissemination of cancer --- Metastases --- Metastatic cancer --- Neoplasm metastasis --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Cancer research --- Pathogenesis --- Dissemination --- Medicine. --- Cancer research. --- Molecular biology. --- Oncology. --- Proteins. --- Cytokines. --- Growth factors. --- Cell biology. --- Medicine & Public Health. --- Cancer Research. --- Molecular Medicine. --- Cytokines and Growth Factors. --- Receptors. --- Cell Biology. --- Pathology --- Genetic toxicology --- Cancer invasiveness --- Cancer of unknown primary origin --- Oncology  . --- Cell receptors. --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- Cellular immunity --- Immune response --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Tumors --- Regulation --- Health Workforce --- Proteins . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Cytokines --- Peptides --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Systems biology