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Since the discovery of the pharmacological and toxicological importance of inhibiting the cyclooxygenase (COX) enzymes by non-steroidal anti-inflammatory drugs (NSAIDs), much research has gone into the development of methods to study the biological functions of COX-1 and COX-2. In Cyclooxygenases: Methods and Protocols, experts and pioneers in the field present the most up-to-date in vitro and in vivo techniques routinely used in COX research. The volume delves into essential topics such as the purification, cloning, and expression of COX enzymes as well as in vitro assays aimed at determining the inhibitory potency of drugs on COX-1 and COX-2 activities, with chapters describing protocols used for the extraction and measurement of the prostanoids. This volume also describes in vivo disease models used to study the roles of COX-1 and COX-2 in gastrointestinal injury, inflammation, and pain. As a book in the highly successful Methods in Molecular Biology™ series, the protocols chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cyclooxygenases: Methods and Protocols serves as an indispensable tool for all scientists seeking the treatment of inflammation, pain, fever, and other harmful conditions.

Toxicology. --- Biochemical engineering. --- Pharmacology/Toxicology. --- Biochemical Engineering. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Bio-process engineering --- Bioprocess engineering --- Biochemistry --- Biotechnology --- Chemical engineering --- Toxicology

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Consumers prefer food products that are tasty, healthy and convenient. Encapsulation is an important way to meet these demands by delivering food ingredients at the right time and right place. For example, encapsulates may allow flavour retention, mask bad tasting or bad smelling components, stabilize food ingredients and/or increase their bioavailability. Encapsulation may also be used to immobilise cells or enzymes in the production of food materials or products, such as fermentation or metabolite production. This book provides a detailed overview of technologies for preparing and characterisation of encapsulates for food active ingredients to be used in food products, food processing or food production. The book is aimed to inform people who work in the academia or R&D of companies on delivery of food compounds via encapsulation and on food processing using immobilized cells or enzymes, with both a limited and an advantaged knowledge of the field. The structure of the book is according to the use of encapsulates for a specific application. Emphasis has been put to strategy, since encapsulation technologies may change. Most chapters include application possibilities of the encapsulation technologies in specific food products or processes. The first part of the book reviews general technologies, food-grade materials and characterization methods for encapsulates. The second part of the book, discusses encapsulates of active ingredients (i.e. aroma, fish oil, minerals, vitamins, peptides, proteins, probiotics) for specific food applications. The last part of the book describes immobilization technologies of cells and enzymes for use within food fermentation processes (like beer, wine, dairy and meat) and food production (e.g., sugar conversion, production of organic acids or amino acids, and hydrolysis of triglycerides). Edited by two leading experts in the field, Encapsulation Technologies for Food Active Ingredients and Food Processing will be a valuable reference source for those working in the academia or food industry. The editors work either in industry or university, and they have brought together in this book contributions from both fields. Dr. Nicolaas Jan (Klaas-Jan) Zuidam is leading the skillbase group ‘Controlled Delivery of Food Actives’ and is a member of the management team of the Flavour Generation & Delivery department within Unilever Research and Development in Vlaardingen, The Netherlands. Since 1990, he has been working on encapsulation, respectively, in the area of pharmaceutics, gene therapy, laundry and foods. He is an author of more than 35 peer-reviewed articles and book chapters, and holds 2 patents. Dr. Viktor A. Nedovic is an associate professor at the Department of Food Technology and Biochemistry, Faculty of Agriculture, University of Belgrade, Belgrade, Republic of Serbia. Since 1989, he has been working on immobilisation, co-immobilisation, encapsulation and bioreactor system design in the fields of food production and fermentation processes. He is an author of around 200 articles published in journals, books and proceedings. He has also served as co-editor of two important books on cell immobilisation: Fundamentals of Cell Immobilisation Biotechnology (Kluwer Academic Publisher, 2004) and Applications of Cell Immobilisation Biotechnology (Springer, 2005).

Controlled release technology. --- Food -- Analysis. --- Food -- Packaging. --- Microencapsulation. --- Controlled release technology --- Microencapsulation --- Food --- Health & Biological Sciences --- Chemical & Materials Engineering --- Biomedical Engineering --- Chemical Engineering --- Engineering & Applied Sciences --- Analysis --- Packaging --- Packaging. --- Encapsulation, Particle --- Particle encapsulation --- Groceries --- Chemistry. --- Biotechnology. --- Biochemical engineering. --- Food Science. --- Chemistry/Food Science, general. --- Biochemical Engineering. --- Food science. --- Bio-process engineering --- Bioprocess engineering --- Biochemistry --- Biotechnology --- Chemical engineering --- Physical sciences --- Genetic engineering --- Science --- Food—Biotechnology.

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Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric Applications of MCR-Derived Heterocycles in Drug Discovery.

Chemistry --- Physical Sciences & Mathematics --- Biochemistry --- Heterocyclic compounds. --- Macrocyclic compounds. --- Compounds, Macrocyclic --- Macrocycles (Chemistry) --- Cycloids, Mixed (Chemistry) --- Heteroatomic compounds --- Heterocycles --- Mixed cycloids (Chemistry) --- Chemistry. --- Biochemical engineering. --- Organic chemistry. --- Medicinal chemistry. --- Organic Chemistry. --- Biochemical Engineering. --- Medicinal Chemistry. --- Heterocyclic compounds --- Macromolecules --- Organic cyclic compounds --- Chemistry, Organic. --- Biochemistry. --- Bio-process engineering --- Bioprocess engineering --- Biotechnology --- Chemical engineering --- Organic chemistry --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Composition --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry

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Although the use of water-soluble polymer beads is on the rise in many fields, the literature offers only scattered chapters in a handful of books on the topic. Polymer Macro- and Micro-Gel Beads: Fundamentals and Applications fills this void. It covers both the properties and traditional and novel applications of polymeric beads, making it a crucial addition to the literature. This book describes numerous methods of bead production, as well as the techniques used to modify them and to estimate their physical and chemical properties. A full description of past and present developments and applications of beads in the fields of agriculture, biotechnology, environmental studies, medicine, pharmacology, and food are presented. Amos Nussinovitch is a Professor of Food Science and Technology at The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem. He is an internationally recognized expert on hydrocolloid applications and works in the areas of structure and texture of wet and dry beads, liquid-core capsules, different polymeric beads for water denitrification and beads as part of novel cellular solids, among many other applications.

Colloids. --- Polymers --- Beads --- Chemistry --- Chemical & Materials Engineering --- Physical Sciences & Mathematics --- Engineering & Applied Sciences --- Organic Chemistry --- Materials Science --- Polymers. --- Beads. --- Polymere --- Polymeride --- Polymers and polymerization --- Chemistry. --- Pharmacology. --- Biochemical engineering. --- Food --- Polymer Sciences. --- Food Science. --- Biochemical Engineering. --- Pharmacology/Toxicology. --- Biotechnology. --- Macromolecules --- Food science. --- Toxicology. --- Bio-process engineering --- Bioprocess engineering --- Biochemistry --- Biotechnology --- Chemical engineering --- Science --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Polymers  . --- Food—Biotechnology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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Thermo-Fluid Dynamics of Two-Phase Flow, Second Edition focuses on the fundamental physics of two-phase flow. The authors present the detailed theoretical foundation of multi-phase flow thermo-fluid dynamics as they apply to: Nuclear reactor transient and accident analysis; Energy systems; Power generation systems; Chemical reactors and process systems; Space propulsion; Transport processes. This edition features updates on two-phase flow formulation and constitutive equations and new coverage of the lift force and Basset force models, which are of particular significance for those working in the field of computational fluid dynamics, new equations and coverage of detailed one-dimensional drift flux models and a new chapter on porous media formulation, which are important for practicing engineers.   Thermo-Fluid Dynamics of Two-Phase Flow, Second Edition is a must have reference for graduate students, scientists and engineers who need in-depth theoretical foundations to solve two-phase flow problems in various technological systems.

Technology. --- Thermodynamics. --- Two-phase flow. --- Two-phase flow --- Thermodynamics --- Engineering & Applied Sciences --- Civil & Environmental Engineering --- Applied Mathematics --- Civil Engineering --- Fluid dynamics. --- Biochemical engineering. --- Electrical engineering. --- Hydraulic engineering. --- Engineering, Hydraulic --- Electric engineering --- Bio-process engineering --- Bioprocess engineering --- Engineering. --- Energy. --- Electric power production. --- Fluid mechanics. --- Engineering Fluid Dynamics. --- Energy Technology. --- Biochemical Engineering. --- Energy, general. --- Chemistry, Physical and theoretical --- Dynamics --- Mechanics --- Physics --- Heat --- Heat-engines --- Quantum theory --- Biochemistry --- Biotechnology --- Chemical engineering --- Engineering --- Fluid mechanics --- Hydraulics --- Shore protection --- Energy Systems. --- Energy systems. --- Hydromechanics --- Continuum mechanics