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Gene Delivery into Mammalian Cells: An Overview on Existing Approaches Employed In Vitro and In Vivo, by Peter Hahn and Elizabeth Scanlan * Strategies for the Preparation of Synthetic Transfection Vectors, by Asier Unciti-Broceta, Matthew N. Bacon, and Mark Bradley * Cationic Lipids: Molecular Structure/Transfection Activity Relationships and Interactions with Biomembranes, by Rumiana Koynova and Boris Tenchov * Hyperbranched Polyamines for Transfection, by Wiebke Fischer, Marcelo Calderon, and Rainer Haag * Carbohydrate Polymers for Nonviral Nucleic Acid Delivery, by Antons Sizovs, Patrick M. McLendon, Sathya Srinivasachari, and Theresa M. Reineke * Cationic Liposome-Nucleic Acid Complexes for Gene Delivery and Silencing: Pathways and Mechanisms for Plasmid DNA and siRNA, by Kai K. Ewert, Alexandra Zidovska, Ayesha Ahmad, Nathan F. Bouxsein, Heather M. Evans, Christopher S. McAllister, Charles E. Samuel, and Cyrus R. Safinya * Chemically Programmed Polymers for Targeted DNA and siRNA Transfection, by Eveline Edith Salcher and Ernst Wagner * Photochemical Internalization: A New Tool for Gene and Oligonucleotide Delivery, by Kristian Berg, Maria Berstad, Lina Prasmickaite, Anette Weyergang, Pål K. Selbo, Ida Hedfors, and Anders Høgset * Visualizing Uptake and Intracellular Trafficking of Gene Carriers by Single-Particle Tracking, by N. Ruthardt and C. Bräuchle

Life Sciences. --- Nucleic Acid Chemistry. --- Biochemical Engineering. --- Bioorganic Chemistry. --- Life sciences. --- Biochemical engineering. --- Bioorganic chemistry. --- Nucleic acids. --- Sciences de la vie --- Génie biochimique --- Chimie bioorganique --- Acides nucléiques --- Transfection --- Nucleic acids --- Genetic transformation

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RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.

Antisense RNA. --- Catalytic RNA. --- RNA. --- Antisense RNA --- Catalytic RNA --- Gene Silencing --- RNA, Antisense --- RNA, Small Untranslated --- Antisense Elements (Genetics) --- Epigenesis, Genetic --- RNA, Untranslated --- RNA --- MicroRNAs --- RNA Interference --- Nucleic Acids, Nucleotides, and Nucleosides --- Gene Expression Regulation --- Nucleic Acids --- Genetic Processes --- Chemicals and Drugs --- Genetic Phenomena --- Phenomena and Processes --- Biology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Biophysics --- Animal Biochemistry --- Genetic engineering. --- Designed genetic change --- Engineering, Genetic --- Gene splicing --- Genetic intervention --- Genetic surgery --- Ribonucleic acid --- Ribose nucleic acid --- Medicine. --- Human genetics. --- Human physiology. --- Molecular biology. --- Biochemistry. --- Nucleic acids. --- Cell biology. --- Biomedicine. --- Human Physiology. --- Cell Biology. --- Biochemistry, general. --- Molecular Medicine. --- Nucleic Acid Chemistry. --- Human Genetics. --- Genetic recombination --- Biotechnology --- Transgenic organisms --- Nucleic acids --- Ribose --- Cytology. --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Polynucleotides --- Biomolecules --- Clinical sciences --- Medical profession --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Physiology --- Human body --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Composition --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Systems biology --- Medicine --- Biomaterials. --- Medical genetics. --- Biomedical Research. --- Nucleic Acid. --- Medical Genetics. --- Research. --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Genetic disorders --- Biological research --- Biomedical research --- Genetic aspects