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In 1988, Gavril W. Pasternak published the first edition of this seminal text. It was a lucid account of the latest knowledge on opiate receptors and related receptor subtypes, a then controversial field, providing an integrated approach correlating the biochemical, physiological, and pharmacological aspects of opiate reaction. Fully revised and expanded, The Opiate Receptors, 2nd edition presents all the advances made in the field in the past twenty years. It covers a wide variety of topics including, but not limited to, the following: pharmacology of opioid drugs; endogenous opioids; molecular biology of mu receptors; molecular biology of delta receptors; kappa opioid receptor gene and the regulatory mechanisms of its protein expression; opioid receptor signal transduction mechanisms; mu opioid receptor mediated analgesia and reward; kappa opioid receptor function; delta opioid receptor function; genetics of opioid receptor functions in mice; opioid receptor trafficking; opioid receptor dimerization; molecular modulation of in vivo tolerance; and genetics of opioid actions. Written by leading international researchers in the field, this new edition is as groundbreaking and vital as its predecessor.

Endorphins -- Receptors. --- Endorphins. --- Opioids -- Receptors. --- Opioids. --- Receptors. --- Endorphins --- Opioids --- Receptors, Neuropeptide --- Biological Science Disciplines --- Opioid Peptides --- Receptors, G-Protein-Coupled --- Peptides --- Neuropeptides --- Receptors, Neurotransmitter --- Receptors, Cell Surface --- Receptors, Peptide --- Natural Science Disciplines --- Amino Acids, Peptides, and Proteins --- Nerve Tissue Proteins --- Disciplines and Occupations --- Membrane Proteins --- Chemicals and Drugs --- Proteins --- Receptors, Opioid --- Physiology --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Animal Biochemistry --- Neurology --- Receptors --- Opioid receptors --- Endorphin receptors --- Morphine receptors --- Narcotic receptors --- Opiate receptors --- Medicine. --- Neurosciences. --- Biomedicine. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system

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The need to continually discover new agents for the control or treatment of invertebrate pests and pathogens is undeniable. Agriculture, both animal and plant, succeeds only to the extent that arthropod and helminth consumers, vectors and pathogens can be kept at bay. Humans and their companion animals are also plagued by invertebrate parasites. The deployment of chemical agents for these purposes inevitably elicits the selection of resistant populations of the targets of control, necessitating a regular introduction of new kinds of molecules. Experience in other areas of chemotherapy has shown that a thorough understanding of the biology of disease is an essential platform upon which to build a discovery program. Unfortunately, investment of research resources into understanding the basic physiology of invertebrates as a strategy to illuminate new molecular targets for pesticide and parasiticide discovery has been scarce, and the pace of introduction of new molecules for these indications has been slowed as a result. An exciting and so far unexploited area to explore in this regard is invertebrate neuropeptide physiology. This book was assembled to focus attention on this promising field by compiling a comprehensive review of recent research on neuropeptides in arthropods and helminths, with contributions from many of the leading laboratories working on these systems.

Insect hormones. --- Neuropeptides. --- Pesticides. --- Neuropeptides --- Insect hormones --- Pesticides --- Invertebrates --- Peptides --- Receptors, Neurotransmitter --- Biological Science Disciplines --- Anti-Infective Agents --- Receptors, Peptide --- Nerve Tissue Proteins --- Receptors, Cell Surface --- Proteins --- Amino Acids, Peptides, and Proteins --- Natural Science Disciplines --- Animals --- Therapeutic Uses --- Eukaryota --- Membrane Proteins --- Chemicals and Drugs --- Disciplines and Occupations --- Pharmacologic Actions --- Chemical Actions and Uses --- Organisms --- Arthropods --- Antiparasitic Agents --- Helminths --- Pharmacology --- Receptors, Neuropeptide --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Economic poisons --- Brain peptides --- Medicine. --- Human physiology. --- Parasitology. --- Biomedicine. --- Human Physiology. --- Biomedicine general. --- Biology --- Human biology --- Medical sciences --- Physiology --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Agricultural chemicals --- Pests --- Poisons --- Hormones --- Insects --- Nerve tissue proteins --- Neurotransmitters --- Control --- Equipment and supplies --- Endocrinology --- Medical parasitology. --- Human beings --- Human parasitology --- Parasitology --- Parasitic diseases --- Parasites --- Biomedicine, general. --- Health Workforce