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Macrocyclic compounds. --- Heterocyclic chemistry. --- Heteroatomic chemistry --- Chemistry, Organic --- Compounds, Macrocyclic --- Macrocycles (Chemistry) --- Heterocyclic compounds --- Macromolecules

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DNA damage --- Environmental pollution --- Carcinogens --- Oxidate stress --- Free radicals --- Amines --- Heterocyclic compounds --- Mutagens --- Estrogens --- DNA repair --- physiology --- toxicity

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Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric Applications of MCR-Derived Heterocycles in Drug Discovery.

Chemistry --- Physical Sciences & Mathematics --- Biochemistry --- Heterocyclic compounds. --- Macrocyclic compounds. --- Compounds, Macrocyclic --- Macrocycles (Chemistry) --- Cycloids, Mixed (Chemistry) --- Heteroatomic compounds --- Heterocycles --- Mixed cycloids (Chemistry) --- Chemistry. --- Biochemical engineering. --- Organic chemistry. --- Medicinal chemistry. --- Organic Chemistry. --- Biochemical Engineering. --- Medicinal Chemistry. --- Heterocyclic compounds --- Macromolecules --- Organic cyclic compounds --- Chemistry, Organic. --- Biochemistry. --- Bio-process engineering --- Bioprocess engineering --- Biotechnology --- Chemical engineering --- Organic chemistry --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Composition --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry

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Electronic books. -- local. --- Phthalocyanines. --- Pigments. --- Phthalocyanines --- Heterocyclic Compounds, 2-Ring --- Biological Factors --- Indoles --- Pigments, Biological --- Heterocyclic Compounds --- Chemicals and Drugs --- Chemistry --- Inorganic Chemistry --- Biochemistry --- Physical Sciences & Mathematics --- Phthalocyanine pigments --- Phthalocyanins --- Chemistry. --- Inorganic chemistry. --- Organic chemistry. --- Physical chemistry. --- Optical materials. --- Electronic materials. --- Nanotechnology. --- Inorganic Chemistry. --- Optical and Electronic Materials. --- Organic Chemistry. --- Physical Chemistry. --- Paint materials --- Coloring matter --- Paint --- Pigments --- Chemistry, inorganic. --- Chemistry, Organic. --- Chemistry, Physical organic. --- Chemistry, Physical organic --- Chemistry, Organic --- Chemistry, Physical and theoretical --- Molecular technology --- Nanoscale technology --- High technology --- Organic chemistry --- Optics --- Materials --- Inorganic chemistry --- Inorganic compounds --- Chemistry, Theoretical --- Physical chemistry --- Theoretical chemistry --- Electronic materials

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Extensive research into the molecular mechanisms of cancer disease has heralded a new age of targeted therapy. In malignant cells, key proteins that are crucial to tumor growth and survival are now being targeted directly with rationally designed inhibitors. Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention. This textbook, written by acknowledged experts, provides a broad overview of the small molecules currently used for the treatment of malignant diseases and discusses interesting novel compounds that are in the process of clinical development to combat cancer.

Antineoplastic agents. --- Cancer -- Molecular aspects. --- Cancer -- Treatment. --- Cancer. --- Cancer --- Antineoplastic agents --- Enzyme Inhibitors --- Aza Compounds --- Cytidine --- Therapeutics --- Therapeutic Uses --- Diseases --- Azacitidine --- Protein Kinase Inhibitors --- Antineoplastic Agents --- Drug Therapy --- Neoplasms --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Pyrimidine Nucleosides --- Pharmacologic Actions --- Ribonucleosides --- Molecular Mechanisms of Pharmacological Action --- Organic Chemicals --- Chemical Actions and Uses --- Nucleosides --- Pyrimidines --- Chemicals and Drugs --- Nucleic Acids, Nucleotides, and Nucleosides --- Heterocyclic Compounds, 1-Ring --- Heterocyclic Compounds --- Medicine --- Oncology --- Health & Biological Sciences --- Molecular aspects --- Treatment --- Molecular aspects. --- Treatment. --- Cancer therapy --- Cancer treatment --- Anticancer agents --- Antineoplastic drugs --- Antineoplastics --- Antitumor agents --- Antitumor drugs --- Cytotoxic drugs --- Inhibitors, Neoplasm --- Neoplasm inhibitors --- Therapy --- Medicine. --- Cancer research. --- Hematology. --- Oncology. --- Medicine & Public Health. --- Cancer Research. --- Haematology --- Internal medicine --- Blood --- Tumors --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Drugs --- Chemotherapy