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This volume is part of a book series that was first published in 10-volumes by Kluwer in 1989 under the series editorship of Professor Hans E. Kaiser, D.Sc., former Professor of Pathology at the School of Medicine, University of Maryland at Baltimore, MD, USA along with other leaders in the field of Cancer. In order to encompass the growing body of knowledge on various aspects of cancer growth and progression since then, the series has now been expanded to 17 volumes. This volume is a comprehensive update on the mechanisms of tumorigenesis, and includes the advances in the field, as provided by the use of the most recent molecular techniques (microarray, proteomic, and other omics). While the first portion of the book contains chapters discussing pediatric cancer, the influence of environmental factors and oncogene activity in tumorigenesis, the second portion of the book is structured by organ sites (Esophagus, Breast, Pancreas, Colon, Lung, Prostate, Skin, Brain, Endocrine System, Lymphoid System, Bone, Head and Neck, and Cervix). This format provides the reader with easy access to the needed information. This definitive text will offer the medical professionals, whether in research, academia or clinical practice, the latest information endorsed by the world renowned contributors. The broad range of topics will make this a valued reference and provide a wealth of information, making this a "state of the science" on carcinogenesis.

Genetics --- Molecular biology --- Oncology. Neoplasms --- Human genetics --- genen --- medische genetica --- oncologie --- moleculaire biologie --- genexpressie

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In his 1894 book, Materials for the Study of Variation, William Bateson coined the term Homoeosis with the following prose: The case of the modification of the antenna of an insect into a foot, of the eye of a Crustacean into an antenna, of a petal into a stamen, and the like, are examples of the same kind. It is desirable and indeed necessary that such Variations, which consist in the assumption by one member of a Meristic series, of the form or characters proper to other members of the series, should be recognized as constituting a distinct group of phenomena. ...I therefore propose...the term HOMOEOSIS...; for the essential phenomenon is not that there has merely been a change, but that something has been changed into the likeness of something else. The book was intended as a listing of the kinds of naturally occurring variation that could act as a substrate for the evolutionary process and Bateson took his examples from collections, both private and in museums, of materials displaying morphological oddities. Interestingly the person who also coined the term Genetics  proffered little in the way of speculation on the possible genetic underpinnings of these oddities. It wasn't until the early part of the next century that these changes in meristic series were shown to be heritable.

Genetics --- Human biochemistry --- Human genetics --- Human medicine --- genen --- medische biochemie --- medische genetica --- geneeskunde --- genetica --- insecten --- anno 2000-2099

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The CCN family of genes currently comprises six secreted proteins (designated CCN16 i.e., Cyr61/CCN1; ctgf/CCN2; Nov/CCN3; WISP1/CCN4; WISP2/CCN5, and WISP3/CCN6) showing a strikingly conserved primary structure, with four modules sharing partial identity with IGF binding proteins, Von Willebrand protein, thrombospondin and several matricellular proteins and growth factors. The current view is that CCN proteins modulate signaling pathways that involve regulatory components of the extracellular matrix. As such, they likely act as a central hub in the regulation of mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest and migration of multiple cell types. The 5th international workshop on the CCN family of genes, that was held in Toronto in 2008 brought together scientists from around the world who have an interest in the biological roles of this emerging family of proteins. On an educational point of view, the workshop was a unique place for an efficient diffusion of scientific information. The present book comprises a series of selected manuscripts that are based on the original communications that were presented at the meeting by worldwide leaders in the field of CCN biology. All major aspects of CCN proteins biology in both normal and pathological conditions are covered in this volume, from structure-functions analysis up to the involvement of CCN proteins in complex physiological functions. In addition to reports that support the Yin-Yang concept of CCN proteins driving opposite effects on the same biological process, this book also comprises several contributions that point to CCN proteins as amenable targets for therapeutic manipulation of disease processes. Together with the special issue of Journal of Cell Communication and Signaling in which authors have extended on the original data presented at the meeting, the present Proceedings provide an instant picture and unique update of the state of the art in the CCN field.

Chemical structure --- Chemistry --- Genetics --- Histology. Cytology --- Molecular biology --- Human biochemistry --- Human genetics --- Human medicine --- genen --- medische biochemie --- medische genetica --- protein-engineering --- geneeskunde --- cytologie --- histologie --- eiwitten --- moleculaire biologie --- proteïnen

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The five previous volumes of Pseudomonas series covered the biology of pseudomonads in a wide context, including the niches they inhabit, the taxonomic relations among members of this group, the molecular biology of gene expression in different niches and under different environmental conditions, the analysis of virulence traits in plants, animals and human pathogens as well as the determinants that make some strains useful for biotechnological applications and promotion of plant growth. Pseudomonas volume 6 is intended to collect new information on molecular microbiology, infection and biodiversity. This sixth volume covers the following topics: transcription regulation, virulence control, physiology and metabolism, bacteriology, microbial genetics and genomics. Pseudomonas volume 6 will be of use to researchers working on these bacteria, particularly those studying genomics, physiology, quorum sensing, life styles, metabolism etc. Advanced students in biology, medicine and agronomy will also find this volume a valuable reference during their studies.

Genetics --- Histology. Cytology --- Molecular biology --- Human genetics --- Medical microbiology, virology, parasitology --- Pseudomonas --- genen --- medische microbiologie --- genomen (geneeskunde) --- medische genetica --- genetica --- bacteriologie --- genexpressie