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Dendritic cells. --- Dendritic cells --- Immunology.

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The cyclic ovary can be seen as a site of tissue damage, repair and precisely controlled tissue homeostasis, as long ovulation and luteolysis can be compared with acute and chronic inflammation. Innate immunity appears to be a powerful force in the endocrine system, representing a novel concept. In this monograph, remarkable evidence is given for the immune-privileged ovary being an implant on the chicken chorioallantoic membrane with an areactive mesenchyme. Mild to severe tissue damages due to follicular atresia, follicular rupture, or intraovarian oocyte release do no lasting harm. The most exciting part relates to the analysis of cytokeratin-positive (CK+) cells, comparing the fate mapping of this cell type from the fetal ovary to the adult organ. Findings on toll-like receptor 4 regulation and interferon-gamma-dependent positive effects indicate that CK+ cells from human preovulatory follicles and bovine corpora lutea have similarities with nonlymphoid dendritic cells, a discovery that has the makings of a top story in basic and clinical research on the ovary.

Dendritic cells. --- Natural immunity. --- Ovaries. --- Chordata --- Scleroproteins --- Adnexa Uteri --- Mononuclear Phagocyte System --- Antigen-Presenting Cells --- Intermediate Filament Proteins --- Gonads --- Immunity --- Epithelial Cells --- Immune System --- Cells --- Animals --- Biopolymers --- Genitalia --- Cytoskeletal Proteins --- Genitalia, Female --- Immune System Phenomena --- Proteins --- Endocrine Glands --- Dendritic Cells --- Keratins --- Vertebrates --- Ovary --- Immunity, Innate --- Anatomy --- Hemic and Immune Systems --- Eukaryota --- Urogenital System --- Endocrine System --- Amino Acids, Peptides, and Proteins --- Polymers --- Phenomena and Processes --- Organisms --- Chemicals and Drugs --- Macromolecular Substances --- Medicine --- Health & Biological Sciences --- Gynecology & Obstetrics --- Ovaries --- Immunity. --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- Medicine. --- Human physiology. --- Immunology. --- Reproductive medicine. --- Medicine & Public Health. --- Reproductive Medicine. --- Human Physiology. --- Adnexa uteri --- Ovum --- Disease resistance --- Immunobiology --- Life sciences --- Serology --- Human biology --- Medical sciences --- Physiology --- Human body --- Human reproduction --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Health aspects