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Neoplasms --- Respiratory diseases --- apoptosis --- Quercetin --- Cancer pulmonaire --- Acide valproique --- Acide éthacrynique

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In this book, scientists pioneering the field have compiled a series of focused chapters to highlight the relevance of the BCL‑2 family of proteins in apoptosis, physiology and disease. An important focus of this volume is considering the potential TH ERA PEUT IC benefits of targeting apoptosis pathways in the context of human disease. Readers interested in understanding how a cell handles stress and the consequences of dysregulation of this process for human disease will find this book very valuable. It attempts to describe a fascinating area of research where physiology and biomedicine converge at different levels, revealing a trip from the molecular regulation of apoptosis to the impact of this process to the physiology of a whole organism.

Apoptosis. --- Tumor proteins. --- Apoptosis --- Tumor proteins --- Bcl-2 protein family. --- Apoptosis Regulatory Proteins --- Cell Death --- Biological Science Disciplines --- Medicine --- Diseases --- Metabolic Phenomena --- Proto-Oncogene Proteins --- Health Occupations --- Phenomena and Processes --- Intracellular Signaling Peptides and Proteins --- Natural Science Disciplines --- Cell Physiological Processes --- Oncogene Proteins --- Disciplines and Occupations --- Cell Physiological Phenomena --- Proteins --- Neoplasm Proteins --- Peptides --- Pathology --- Proto-Oncogene Proteins c-bcl-2 --- Metabolism --- Neoplasms --- Physiology --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Biology --- Health & Biological Sciences --- Cytology --- Medicine. --- Human physiology. --- Molecular biology. --- Proteins. --- Biomedicine. --- Human Physiology. --- Protein Science. --- Biomedicine general. --- Molecular Medicine. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Systems biology --- Human biology --- Medical sciences --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Physicians --- Tumor markers --- Cell death --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Composition --- Health Workforce --- Proteins . --- Biomedicine, general.

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Knowledge of cholesterol and its interaction with protein molecules is of fundamental importance in both animal and human biology. This book contains 22 chapters, dealing in depth with structural and functional aspects of the currently known and extremely diverse unrelated families of cholesterol-binding and cholesterol transport proteins. By drawing together this range of topics the Editor has attempted to correlate this broad field of study for the first time. Technical aspects are given considerable emphasis, particularly in relation cholesterol reporter molecules and to the isolation and study of membrane cholesterol- and sphingomyelin-rich "raft" domains. Cell biological, biochemical and clinical topics are included in this book, which serve to emphasize the acknowledged and important benefits to be gained from the study of cholesterol and cholesterol-binding proteins within the biomedical sciences and the involvement of cholesterol in several clinical disorders. It is hoped that by presenting this topic in this integrated manner that an appreciation of the fact that there is much more that needs to be taken into account, studied and understood than the widely discussed "bad and good cholesterol" associated, respectively, with the low- and high-density lipoproteins, LDL and HDL.

Carrier proteins. --- Cholesterol -- Metabolism. --- Cholesterol --- Carrier proteins --- Sterols --- Proteins --- Cholestenes --- Carrier Proteins --- Membrane Lipids --- Amino Acids, Peptides, and Proteins --- Cholestanes --- Lipids --- Steroids --- Chemicals and Drugs --- Polycyclic Compounds --- Human Anatomy & Physiology --- Chemistry --- Biology --- Biology - General --- Animal Biochemistry --- Cytology --- Biochemistry --- Health & Biological Sciences --- Physical Sciences & Mathematics --- Metabolism --- Cholesterol. --- Metabolism. --- Binding proteins --- Transport proteins --- Cholesterin --- Life sciences. --- Biochemistry. --- Proteins. --- Lipids. --- Apoptosis. --- Life Sciences. --- Biochemistry, general. --- Lipidology. --- Protein Science. --- Animal Biochemistry. --- Biological transport --- Protein binding --- Isopentenoids --- Low-cholesterol diet

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From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here the authors give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here.

Phosphoinositides. --- Cell proliferation. --- Cell death. --- Apoptosis. --- Phosphatidylinositides --- Phosphatidylinositol phosphates --- Cell renewal --- Cellular proliferation --- Medicine. --- Cancer research. --- Human physiology. --- Molecular biology. --- Biomedicine. --- Cancer Research. --- Human Physiology. --- Molecular Medicine. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Human biology --- Medical sciences --- Physiology --- Human body --- Cancer research --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Cell death --- Cell degeneration --- Cells --- Death (Biology) --- Cell cycle --- Cell division --- Cell populations --- Phospholipids --- Inositol --- Growth --- Oncology. --- Tumors --- Health Workforce --- Cancer. --- Medicine --- Biology --- Cancer Biology. --- Biomedical Research. --- Research. --- Biological research --- Biomedical research --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors