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Beneficiation of Phosphates: Technology Advance and Adoption is the exclusive source of information on research and technology advances in phosphate mineral processing. More than 100 internationally respected authors from 20 countries explore the latest developments in an industry experiencing unprecedented change and prosperity.

Phosphates. --- Ore-dressing. --- Flotation.

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Phosphates. --- Salt industry and trade --- Salt industry and trade

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Mandible --- Calcium Phosphates --- Bone Transplantation --- Bone Substitutes --- Biocompatible Materials --- Tissue Scaffolds --- surgery --- therapeutic use --- methods --- therapeutic use --- metabolism --- chemistry

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From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here the authors give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here.

Phosphoinositides. --- Cell proliferation. --- Cell death. --- Apoptosis. --- Cell renewal --- Cellular proliferation --- Phosphatidylinositides --- Phosphatidylinositol phosphates --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cell death --- Cell degeneration --- Cells --- Death (Biology) --- Cell cycle --- Cell division --- Cell populations --- Phospholipids --- Inositol --- Growth --- Oncology. --- Tumors

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Extracellular purines and pyrimidines (ATP, ADP, UTP and adenosine) are released into the extracellular milieu in response to a variety of stress conditions and act as important regulators of vascular homeostasis. This new book is uniquely focused on the signaling actions of extracellular purines in endothelial cells and the crucial role of extracellular purines in regulation of angiogenesis, vascular tone, cell permeability, wound healing, inflammation and cell-to-cell communication. This book examines the responses of endothelial cells, originating from various tissues (such as cornea, pancreas and uterus), to extracellular nucleotides and adenosine under physiological and pathological conditions, i.e. pregnancy, hypoxia, hypertension, inflammation and diabetes. In the book’s 12 chapters, the role of purinergic signaling in endothelium-dependent tissue perfusion, regulation of endothelial barrier function, and angiogenesis are discussed. The mechanisms of ATP release and its role in intercellular communication are also presented. In addition, the book provides the most up to date mechanisms of extracellular nucleotide metabolism by purine-converting ecto-enzymes and their contribution to purinergic signaling in endothelial cells originating from various vascular beds. This book is a valuable resource for biomedical research scientists, clinical scientists, graduate students and health science professionals interested in the mechanisms of extracellular purine function in endothelial cells under physiologic and pathologic conditions.

Adenosine triphosphate -- Physiological effect. --- Endothelins. --- Extracellular enzymes. --- Adenosine triphosphate --- Extracellular enzymes --- Endothelins --- Adenosine Triphosphate --- Endothelial Cells --- Cell Communication --- Physiology --- Adenine Nucleotides --- Biological Science Disciplines --- Epithelial Cells --- Cell Physiological Processes --- Purine Nucleotides --- Ribonucleotides --- Cell Physiological Phenomena --- Natural Science Disciplines --- Cells --- Nucleotides --- Anatomy --- Disciplines and Occupations --- Purines --- Phenomena and Processes --- Nucleic Acids, Nucleotides, and Nucleosides --- Heterocyclic Compounds, 2-Ring --- Chemicals and Drugs --- Heterocyclic Compounds --- Animal Biochemistry --- Biophysics --- Biology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Physiological effect --- Physiological effect. --- Endothelium-dependent contracting factors --- Endothelium-derived contracting factors --- Ectoenzymes --- Exocellular enzymes --- Exoenzymes --- Adenosinetriphosphate --- Adenosinetriphosphoric acid --- Adenylpyrophosphate --- ATP (Biochemistry) --- Medicine. --- Molecular biology. --- Medical biochemistry. --- Pathology. --- Cytokines. --- Growth factors. --- Cell physiology. --- Biomedicine. --- Molecular Medicine. --- Medical Biochemistry. --- Cytokines and Growth Factors. --- Cell Physiology. --- Biomedicine general. --- Peptides --- Vasoconstrictors --- Vascular endothelium --- Enzymes --- Adenine nucleotides --- Phosphates --- Biochemistry. --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Cell function --- Cytology --- Cellular immunity --- Immune response --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Regulation --- Composition --- Biomedicine, general. --- Health Workforce --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Cytokines --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Molecular biochemistry --- Molecular biophysics --- Biomolecules --- Systems biology