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Human molecular genetics --- Human molecular genetics. --- Genome, Human. --- Molecular Biology. --- Génétique moléculaire humaine --- Molecular bases of life. Molecular biology --- 577.2 Molecular bases of life. Molecular biology --- Génétique moléculaire humaine --- genetica --- moleculaire genetica --- 577.2 --- Human genetics --- Molecular genetics --- Molecular biology --- Genome, Human --- Genes --- Human --- Chromosomes, human --- Gene expression --- Genetic techniques --- Human genome project --- Genetics, population --- Humans. --- Chromosomes, Human. --- Gene Expression. --- Genetic Techniques. --- Human Genome Project. --- Genetics, Population. --- Molecular Biology --- Humans --- Chromosomes, Human --- Gene Expression --- Genetic Techniques --- Human Genome Project --- Genetics, Population --- Genes.

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The fourth, completely revised edition of this classic reference and textbook presents a cohesive and up-to-date exposition of the concepts, results, and problems underlying theory and practice in human and medical genetics. In the 10 years since the appearance of the third edition, many new insights have emerged for understanding the genetic basis of development and function in human health and disease. Human genetics, with its emphasis on molecular concepts and techniques, has become a key discipline in medicine and the biomedical sciences. The fourth edition has been extensively expanded by new chapters on timely topics such as epigenetics, pharmacogenetics, gene therapy, cloning, and genetic epidemiology, and databases for basic and clinical genetics. In addition a multi/chapter section giving an overview on the main model organisms (mouse, dog, worm, fly, fish) used in human genetics research has been introduced. This book will be of interest to human and medical geneticists, scientists in all biomedical sciences, physicians and epidemiologists, as well as to graduate and postgraduate students who desire to learn the fundamentals of this fascinating field.

Genetics, Medical. --- Human genetics. --- Human genetics --- Medicine --- Biology --- Health Occupations --- Biological Science Disciplines --- Genetics, Medical --- Genetics --- Natural Science Disciplines --- Disciplines and Occupations --- Health & Biological Sciences --- Pathology --- Genetics. --- Medicine. --- Biomedicine. --- Human Genetics. --- Heredity, Human --- Human biology --- Physical anthropology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Xenética humana

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The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny nucleoid, have remained elusive. How is it that bacteria are able to package their genetic information within the confined space of the nucleoid while at the same time making it accessible for gene expression and DNA replication? This book, featuring the latest research by leading experts, describes the advanced methods being applied to the problem and shows how their work is contributing to our growing understanding of the ways that bacterial DNA storage, replication, recombination and gene expression are managed and coordinated. With due consideration paid to archaea and eukaryotes, the authors show how evolution in bacteria has provided solutions to these problems that range from the very sophisticated to the surprisingly simple. This comprehensive overview of bacterial chromatin clearly defines the fundamental concepts and goes on to show how cells inherit both chromosomal and extra-chromosomal genetic information at cell division. Several chapters are devoted to the central role played by nucleoid-associated proteins, with specific material on imaging the nucleoids, the physics of their structure and segregation, and the transcriptional regulation conducted by nucleoid-associated proteins. No other book currently available provides such a complete picture of these essential cellular processes.

Bacterial chromatin -- Congresses. --- Bacterial chromatin. --- Bacterial Proteins. --- Chromatin. --- Nucleoproteins -- Congresses. --- Bacterial chromatin --- Bacterial Structures --- Chromosome Structures --- Chromosomes --- Nucleoproteins --- DNA --- Proteins --- DNA, Bacterial --- Chromosomes, Bacterial --- Chromatin --- Bacterial Proteins --- Genetic Structures --- Cellular Structures --- Amino Acids, Peptides, and Proteins --- Anatomy --- Nucleic Acids --- Genetic Phenomena --- Chemicals and Drugs --- Nucleic Acids, Nucleotides, and Nucleosides --- Cells --- Intranuclear Space --- Phenomena and Processes --- Cell Nucleus Structures --- Cell Nucleus --- Intracellular Space --- Biology --- Microbiology & Immunology --- Health & Biological Sciences --- Life sciences. --- Biochemistry. --- Microbiology. --- Bacteriology. --- Biophysics. --- Biological physics. --- Life Sciences. --- Biochemistry, general. --- Biomedicine general. --- Biophysics and Biological Physics. --- Medicine. --- Biological and Medical Physics, Biophysics. --- Microbiology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Microbial biology --- Microorganisms --- Composition --- Biomedicine, general. --- Health Workforce --- Biological physics --- Physics --- Medicine --- Bacteria. --- Biomedical Research. --- Research. --- Germs --- Microbes --- Prokaryotes --- Biological research --- Biomedical research

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Grown exponentially by the genomic revolution, the use of the rat as a model of choice for physiological studies continues in popularity and at a much greater depth of understanding. In Rat Genomics: Methods and Protocols, world-wide experts provide both practical information for researchers involved in genomic research in the rat along with a more contextual discussion about the usefulness of the rat in physiological or translational research in different organs and systems. The volume extensively covers topics including genome sequencing, quantitative trait loci mapping, and the identification of single nucleotide polymorphisms as well as the development of transgenic technologies such as nuclear cloning, lentiviral-mediated transgenesis, gene knock-down using RNA interference, gene knock-out by mutagenesis, and zinc finger nucleases plus exciting advances in the obtention of rat embryonic cell lines. As a volume in the highly successful Methods in Molecular Biology™ series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Comprehensive and up-to-date, Rat Genomics: Methods and Protocols thoroughly covers the current techniques used in labs around the world and overviews the applications of the data obtained, making it certain to be useful to the scientific community as a key source of references and methods.

Biochemistry. --- Zoology. --- Human physiology. --- Animal genetics. --- Transgenic organisms. --- Biochemistry, general. --- Human Physiology. --- Animal Genetics and Genomics. --- Transgenics. --- Genetically engineered organisms --- Genetically modified organisms --- GEOs (Genetically engineered organisms) --- GMOs (Genetically modified organisms) --- Organisms --- Genetic engineering --- Genetics --- Biology --- Natural history --- Animals --- Biological chemistry --- Chemical composition of organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Human biology --- Physiology --- Human body --- Composition --- Genetics. --- Genetics and Genomics. --- Experimental Organisms. --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Technique.

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Molecular genetics --- Genetics --- Molecular biology --- Molecular Biology. --- Genetic Diseases, Inborn. --- Genetic Phenomena. --- Genetics. --- Molecular biology. --- Molecular genetics. --- Erbkrankheit --- Molekulargenetik --- Erbkrankheit. --- Molekulargenetik. --- Molekulare Genetik --- Biochemische Genetik --- Molecular biochemistry --- Molecular biophysics --- Genetic Concepts --- Genetic Phenomenon --- Genetic Process --- Genetic Processes --- Concept, Genetic --- Concepts, Genetic --- Genetic Concept --- Phenomena, Genetic --- Phenomenon, Genetic --- Process, Genetic --- Processes, Genetic --- Genetic Diseases --- Genetic Disorders --- Hereditary Disease --- Inborn Genetic Diseases --- Single-Gene Defects --- Hereditary Diseases --- Defect, Single-Gene --- Defects, Single-Gene --- Disease, Genetic --- Disease, Hereditary --- Disease, Inborn Genetic --- Diseases, Genetic --- Diseases, Hereditary --- Diseases, Inborn Genetic --- Disorder, Genetic --- Disorders, Genetic --- Genetic Disease --- Genetic Disease, Inborn --- Genetic Disorder --- Inborn Genetic Disease --- Single Gene Defects --- Single-Gene Defect --- Genetische Krankheit --- Heredopathie --- Genetisch bedingte Krankheit --- Genetisches Syndrom --- Erbkrankheiten --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Genetik --- Molekularbiologie --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Molecular Biology --- Genetics, Medical --- Angeborene Krankheit --- Genetic Phenomena