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Primary sensory neurons respond to peripheral stimulation by projecting to the spinal cord, where a population of neurons respond to damaging stimuli and terminate in the superficial layers of the dorsal horn. Therefore, the dorsal horns constitute the first relay site for nociceptive fibre terminals which make synaptic contacts with second-order neurons. It has recently become clear, however, that the strength of this first pain synapse is plastic and modifiable by several modulators--including neuronal and non-neuronal regulators--and studies on the fundamental processes regulating this plasticity have resulted in the identification of new targets for the treatment of chronic pain. With special emphasis on neuropathic pain, Synaptic Plasticity in Pain examines these targets and mechanisms for chronic pain in the dorsal horn, providing up-to-date research from the world's foremost pain experts. The book also delineates anatomical circuits for pain in the dorsal horn, explores the fast and slow transmissions at the pain synapse, and discusses how synaptic plasticity can be monitored in the dorsal horn during pain transmission. Synaptic Plasticity in Pain is published at a time of intensive experimental research aimed at finding new mechanisms and targets for the treatment of chronic pain. This book will be of importance to a wide readership in the pain field including PhD students, doctoral scientists, and academics. It will also appeal to scientists who are interested in synaptic plasticity associated with other CNS functions, and to private sector drug discovery teams, who will find solid scientific support to their research in these pages. About the Editor: Dr. Marzia Malcangio holds a Bachelors' degree in pharmaceutical chemistry and a PhD in Pharmacology from the University of Florence, Italy. She spent most of her active scientific life in London,UK, establishing an internationally renowned laboratory devoted to the biology of spinal cord mechanisms underlying chronic pain. Her current work explores novel approaches for targeting neuropathic and arthritic pain, and the involvement of microglia and the mechanisms governing microglial-neuronal communication. Dr. Malcangio lives in London with her husband and two sons.

Medicine. --- Neurobiology. --- Neurology. --- Neuroplasticity. --- Neurosciences. --- Pain Medicine. --- Pain --Physiological aspects. --- Toxicology. --- Neuroplasticity --- Pain --- Neuronal Plasticity --- Nervous System Physiological Processes --- Nervous System Physiological Phenomena --- Musculoskeletal and Neural Physiological Phenomena --- Phenomena and Processes --- Pathology --- Neurology --- Neuroscience --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Physiological aspects --- Physiological aspects. --- Nervous system plasticity --- Neural adaptation --- Neural plasticity --- Neuronal adaptation --- Neuronal plasticity --- Plasticity, Nervous system --- Soft-wired nervous system --- Synaptic plasticity --- Pharmacology. --- Pain medicine. --- Biomedicine. --- Pharmacology/Toxicology. --- Adaptation (Physiology) --- Neurophysiology --- Developmental neurobiology --- Nervous system --- Neuropsychiatry --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Neural sciences --- Neurological sciences --- Medical sciences --- Neurosciences --- Diseases --- Toxicology --- Algiatry --- Neurology . --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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Over the last few years, a considerable number of different cell adhesion molecules (CAMs) have been identified that are imperative for synapse formation and maintenance. Recent research, however, has also revealed that many synaptic connections are highly dynamic and not as stable as initially thought. A delicate balance between adhesive and anti-adhesive events at the synapse suggests that CAM functions are highly regulated. Dr. Michael Hortsch and Dr. Hisashi Umemori's The Sticky Synapse: Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance presents the first comprehensive synopsis on how adhesive proteins contribute to synapse formation, function, and remodeling. Topics discussed range from general synaptic processes, such as neuromuscular junction and CNS synapse formation, to CAM-specific chapters on Cadherins, Ig-domain CAMs, Neuroligins, extracellular matrix molecules, Connexins and many others, and how these CAM families contribute specifically to synaptic functionality. The wide range of general and technical information offered in this book will appeal to students, researchers, and clinicians in the fields of molecular and cellular neuroscience, neurophysiology, and developmental neurobiology. . About the editors: Dr. Michael Hortsch holds a Diploma degree in Biochemistry from the Free University Berlin and a Ph.D. in Biology from the University of Heidelberg in Germany.While working at theWeizmann Institute in Israel, the European Molecular Biology Laboratory in Heidelberg, and at the University of California at Berkeley he has published on topics such as the mechanism of growth factor receptor activation, the transport of proteins across membranes, and the physiological roles of neuronal cell adhesion molecules during nervous system development. He has been a faculty member of the Department of Cell and Developmental Biology at the University of Michigan in Ann Arbor since 1991. Dr. Hortsch has served on scientific review panels for the National Institutes of Health, the National Science Foundation, and other agencies. Dr. Hisashi Umemori is a faculty member of the Molecular and Behavioral Neuroscience Institute and of the Department of Biological Chemistry at the University of Michigan Medical School. He worked with Dr. Tadashi Yamamoto at the Institute of Medical Sciences of the University of Tokyo and analyzed intracellular signaling mechanisms that are involved in myelination and in learning and memory.While working with Dr. Joshua R. Sanes atWashington University Medical School and at Harvard University, he identified synaptic organizing molecules that promote synapse formation during nervous system development. Currently, his laboratory is working to uncover the molecular mechanisms that govern the formation of functional neural circuits in the brain. Dr. Umemori has received various awards, including a Basil O'Connor Award and a Klingenstein Fellowship Award. .

Cell adhesion molecules. --- Synapses. --- Synapses --- Cell adhesion molecules --- Cell Adhesion Molecules --- Cell Adhesion --- Cell Physiological Processes --- Intercellular Junctions --- Nervous System --- Membrane Glycoproteins --- Antigens, Surface --- Glycoproteins --- Membrane Proteins --- Cell Physiological Phenomena --- Cell Membrane Structures --- Antigens --- Anatomy --- Phenomena and Processes --- Proteins --- Biological Factors --- Cell Membrane --- Amino Acids, Peptides, and Proteins --- Cellular Structures --- Chemicals and Drugs --- Cells --- Neuroscience --- Neurology --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Neuroplasticity. --- Neurotrophic functions. --- Physiological effect. --- Golgi, Camillo, --- Ramón y Cajal, Santiago, --- Nervous system plasticity --- Neural adaptation --- Neural plasticity --- Neuronal adaptation --- Neuronal plasticity --- Plasticity, Nervous system --- Soft-wired nervous system --- Synaptic plasticity --- Adhesion molecules (Cytology) --- Adhesion substances (Cytology) --- Cell adhesion substances --- Intercellular adhesion molecules --- Morphoregulatory molecules --- Cajal, Santiago Ramón y, --- Cajal, S. R. --- Doctor Bacteria, --- Bacteria, --- Ramón y Cajal, S. --- Medicine. --- Neurosciences. --- Neurology. --- Cell biology. --- Developmental biology. --- Neurobiology. --- Biomedicine. --- Developmental Biology. --- Cell Biology. --- Neurophysiology --- Adaptation (Physiology) --- Developmental neurobiology --- Biomolecules --- Desmosomes --- Hemidesmosomes --- Nerve endings --- Nerves --- Neural circuitry --- Neural transmission --- Synaptosomes --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Development (Biology) --- Growth --- Ontogeny --- Nervous system --- Neuropsychiatry --- Neurosciences --- Neural sciences --- Neurological sciences --- Medical sciences --- Diseases --- Neurology . --- Ramon y Cajal, Santiago,