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Steroid abuse. --- Brain --- Effect of drugs on.

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This book serves as a tribute to the work of the many investigators who have attempted to understand the role of the androgen receptor (AR) in the development and progression of prostate cancer. The relationship between prostate cancer and androgen status was initially appreciated in the late 1800’s, and then awareness reawakened in the 1940’s by the studies of Charles Huggins and colleagues, for which the Nobel prize was awarded in 1966. The purpose of this book is to provide an up to date review of the molecular and cellular aspects of androgen action in prostate cancer. It includes an overview of the role of androgens in the development of the normal prostate and progression of prostate cancer. Our understanding of androgen metabolism and efforts to target androgen metabolism in the prevention and treatment of prostate cancer is presented. Androgen receptor structure/function relationships and the role of co-regulators are defined. Ligand-independent activation of the androgen receptor and the role of the androgen receptor during progression to the castration recurrent phenotype are discussed. Androgen-regulated genes are elucidated and their roles during prostate cancer progression are defined. Finally, the androgen receptor is presented as a viable target for novel therapies. Together, these reviews should give the reader a comprehensive conceptual framework of androgen action in prostate cancer.

Androgens --Physiological effect. --- Androgens --Receptors. --- Prostate --Cancer. --- Prostate --- Androgens --- Genital Neoplasms, Male --- Receptors, Steroid --- Hormones --- Medicine --- Biological Science Disciplines --- Prostatic Diseases --- Urogenital Neoplasms --- Receptors, Cytoplasmic and Nuclear --- Natural Science Disciplines --- Genital Diseases, Male --- Health Occupations --- Hormones, Hormone Substitutes, and Hormone Antagonists --- Male Urogenital Diseases --- Transcription Factors --- Disciplines and Occupations --- Physiological Effects of Drugs --- Proteins --- Neoplasms by Site --- DNA-Binding Proteins --- Diseases --- Amino Acids, Peptides, and Proteins --- Neoplasms --- Pharmacologic Actions --- Chemical Actions and Uses --- Chemicals and Drugs --- Prostatic Neoplasms --- Pathology --- Receptors, Androgen --- Physiology --- Health & Biological Sciences --- Oncology --- Cancer --- Receptors --- Physiological effect --- Generative organs, Male --- Cancer. --- Medicine. --- Cancer research. --- Human genetics. --- Immunology. --- Medical microbiology. --- Pharmacology. --- Virology. --- Biomedicine. --- Cancer Research. --- Human Genetics. --- Medical Microbiology. --- Pharmacology/Toxicology. --- Cancer in men --- Oncology. --- Microbiology. --- Toxicology. --- Medical virology. --- Medical microbiology --- Virology --- Virus diseases --- Immunobiology --- Life sciences --- Serology --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Microbial biology --- Biology --- Microorganisms --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Tumors --- Toxicology --- Microbiology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research