Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Cette méthode fournit des informations sur les dangers pour la santé qui peuvent résulter d’une exposition à court terme à un article d’essai (gaz, produit volatil, aérosol, substance particulaire) par inhalation. La ligne directrice révisée décrit deux études : un protocole traditionnel (CL50) et un protocole « concentration x temps ». Elle peut être utilisée pour estimer une concentration létale médiane (CL50), une concentration seuil non létale (LC01), et une pente, et pour identifier des susceptibilités possibles liées au sexe. Elle permet une évaluation quantitative des risques et une classification selon le selon le Système général harmonisé de classification et d’étiquetage des produits chimiques. Dans le protocole traditionnel, les animaux sont exposés à une concentration limite, ou à  trois concentrations au moins, pour une durée prédéterminée, en principe 4 heures. En général, 10 animaux sont utilisés pour chaque concentration. Dans le protocole CxT, les animaux sont exposés à une concentration limite ou à une série de concentrations pour des durées multiples. En général, 2 animaux sont utilisés pour chaque CxT. La durée d’observation des animaux (rats de préférence) est d’au moins 14 jours. L’étude comprend des  mesures dont celle du poids, des observations quotidiennes détaillées, et une autopsie générale.

Chemical tests and reagents --- Chemical reagents --- Reagents, Chemical --- Indicators and test-papers --- Chemical tests and reagents.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

La présente Ligne directrice décrit un essai de métamorphose des amphibiens dans le but de dépister certaines substances pouvant intérférer avec le fonctionnement normal de l’axe hypothalamo-hypophyso-thyroidien. L’essai a été validé sur le xénope (Xenopus laevis) qui est donc l’espèce recommandée dans la présente Ligne directrice. L’essai fait usage de trois niveaux de concentrations du produit chimique testé, ainsi que des témoins nécessaires, y compris un témoin-solvant au besoin. L’essai commence avec des têtards au stade de développement 51 sur l’échelle de Nieuwkoop et Faber, et s’étend sur une durée de 21 jours. Quatre cuves répliquats sont utilisés à chaque niveaux de traitement et pour le(s) témoin(s). Après 7 jours d’exposition, un sous-ensemble de têtards provenant de chaque niveau de traitement et du(des) témoin(s) est échantillonné pour mesurer la longueur du membre antérieur. A l’issue de la période d’exposition de 21 jours, le stade de développement, la longueur museau-cloaque et la longueur du membre antérieur sont mesurés chez tous les têtards restants. Un sous-ensemble de têtards provenant de chaque niveau de traitement, y compris du témoin, est fixé (in toto ou disséqué) pour l’évaluation histopathologique de la glande thyroide.

Chemical tests and reagents --- Chemical reagents --- Reagents, Chemical --- Indicators and test-papers --- Chemical tests and reagents.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

A comprehensive introduction to the biology and ecology of plankton.

Plankton --- Indicators (Biology) --- Bioindicators --- Biological environmental indicators --- Biological indicators --- Ecological indicators --- Environmental indicators, Biological --- Sentinel organisms --- Ecology --- Biological monitoring --- Biological reagents --- Water quality biological assessment --- Plankton sampling --- Aquatic biology --- Ecology. --- Measurement.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The largest-ever independent laboratory-based evaluation of rapid diagnostic tests (RDTs) for malaria has shown that some tests on the market perform exceptionally well in tropical temperatures and can detect even low parasite densities in blood samples while other tests were only able to detect the parasite at high parasite densities. This document reports on evaluations co-sponsored by the WHO Regional Office for the Western Pacific (WPRO) WHO-based Special Programme for Research and Training in Tropical Diseases (TDR) and the Foundation for Innovative New Diagnostics (FIND). Testing was per

Malaria -- Diagnosis -- Evaluation. --- Malaria -- Microbiology. --- Plasmodium -- Testing. --- Epidemiologic Research Design --- Statistics as Topic --- Equipment and Supplies --- Protozoan Infections --- Indicators and Reagents --- Mathematical Concepts --- Health Care Evaluation Mechanisms --- Phenomena and Processes --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Epidemiologic Methods --- Laboratory Chemicals --- Parasitic Diseases --- Diseases --- Specialty Uses of Chemicals --- Public Health --- Quality of Health Care --- Investigative Techniques --- Environment and Public Health --- Health Care Quality, Access, and Evaluation --- Chemical Actions and Uses --- Health Care --- Chemicals and Drugs --- Sensitivity and Specificity --- Reagent Kits, Diagnostic --- Malaria --- Medicine --- Health & Biological Sciences --- Infectious Diseases --- Infections, Plasmodium --- Paludism --- Marsh Fever --- Plasmodium Infections --- Remittent Fever --- Fever, Marsh --- Fever, Remittent --- Infection, Plasmodium --- Plasmodium Infection --- Diagnostic Reagents and Test Kits --- Diagnostic Test Kits --- In Vitro Diagnostic Device --- In Vitro Diagnostic Devices --- In Vitro Diagnostic Medical Device --- In Vitro Diagnostic Medical Devices --- Kits, Diagnostic Reagent --- Diagnostic Reagent Kits --- Diagnostic Reagent Kit --- Diagnostic Test Kit --- Kit, Diagnostic Reagent --- Kit, Diagnostic Test --- Kits, Diagnostic Test --- Reagent Kit, Diagnostic --- Test Kit, Diagnostic --- Test Kits, Diagnostic --- Sensitivity --- Specificity --- Specificity and Sensitivity --- Design, Epidemiologic Research --- Designs, Epidemiologic Research --- Epidemiologic Research Designs --- Epidemiological Research Design --- Research Design, Epidemiologic --- Research Designs, Epidemiologic --- Design, Epidemiological Research --- Designs, Epidemiological Research --- Epidemiological Research Designs --- Research Design, Epidemiological --- Research Designs, Epidemiological --- Community-Based Distribution --- Contraceptive Distribution --- Delivery of Healthcare --- Dental Care Delivery --- Distribution, Non-Clinical --- Distribution, Nonclinical --- Distributional Activities --- Healthcare --- Healthcare Delivery --- Healthcare Systems --- Non-Clinical Distribution --- Nonclinical Distribution --- Delivery of Dental Care --- Health Care Delivery --- Health Care Systems --- Activities, Distributional --- Activity, Distributional --- Care, Health --- Community Based Distribution --- Community-Based Distributions --- Contraceptive Distributions --- Deliveries, Healthcare --- Delivery, Dental Care --- Delivery, Health Care --- Delivery, Healthcare --- Distribution, Community-Based --- Distribution, Contraceptive --- Distribution, Non Clinical --- Distributional Activity --- Distributions, Community-Based --- Distributions, Contraceptive --- Distributions, Non-Clinical --- Distributions, Nonclinical --- Health Care System --- Healthcare Deliveries --- Healthcare System --- Non Clinical Distribution --- Non-Clinical Distributions --- Nonclinical Distributions --- System, Health Care --- System, Healthcare --- Systems, Health Care --- Systems, Healthcare --- Healthcare Quality, Access, and Evaluation --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Quality of Care --- Quality of Healthcare --- Care Qualities --- Care Quality --- Health Care Quality --- Healthcare Quality --- Specialty Chemicals and Products --- Environment, Preventive Medicine & Public Health --- Environment, Preventive Medicine and Public Health --- Health, Public --- Parasite Infections --- Parasitic Infections --- Disease, Parasitic --- Diseases, Parasitic --- Infection, Parasite --- Infection, Parasitic --- Infections, Parasite --- Infections, Parasitic --- Parasite Infection --- Parasitic Disease --- Parasitic Infection --- Chemicals, Laboratory --- Epidemiologic Method --- Epidemiological Methods --- Methods, Epidemiologic --- Epidemiological Method --- Method, Epidemiologic --- Method, Epidemiological --- Methods, Epidemiological --- Epidemiology --- Healthcare Evaluation Mechanisms --- Evaluation Mechanism, Healthcare --- Evaluation Mechanisms, Healthcare --- Healthcare Evaluation Mechanism --- Mechanism, Healthcare Evaluation --- Mechanisms, Healthcare Evaluation --- Concept, Mathematical --- Concepts, Mathematical --- Mathematical Concept --- Indicators --- Reagents and Indicators --- Reagents --- Infections, Protozoan --- Histomoniasis --- Histomoniases --- Infection, Protozoan --- Protozoan Infection --- Device, Medical --- Devices, Medical --- Equipment --- Inventories --- Medical Device --- Supplies --- Apparatus and Instruments --- Devices --- Medical Devices --- Device --- Instruments and Apparatus --- Inventory --- Supplies and Equipment --- Area Analysis --- Correlation Studies --- Correlation Study --- Correlation of Data --- Data Analysis --- Estimation Technics --- Estimation Techniques --- Indirect Estimation Technics --- Indirect Estimation Techniques --- Multiple Classification Analysis --- Service Statistics --- Statistical Study --- Statistics, Service --- Tables and Charts as Topic --- Analyses, Area --- Analyses, Data --- Analyses, Multiple Classification --- Analysis, Area --- Analysis, Data --- Analysis, Multiple Classification --- Area Analyses --- Classification Analyses, Multiple --- Classification Analysis, Multiple --- Data Analyses --- Data Correlation --- Data Correlations --- Estimation Technic --- Estimation Technic, Indirect --- Estimation Technics, Indirect --- Estimation Technique --- Estimation Technique, Indirect --- Estimation Techniques, Indirect --- Indirect Estimation Technic --- Indirect Estimation Technique --- Multiple Classification Analyses --- Statistical Studies --- Studies, Correlation --- Studies, Statistical --- Study, Correlation --- Study, Statistical --- Technic, Estimation --- Technic, Indirect Estimation --- Technics, Estimation --- Technics, Indirect Estimation --- Technique, Estimation --- Technique, Indirect Estimation --- Techniques, Estimation --- Techniques, Indirect Estimation --- methods --- Diagnostic Tests, Routine --- Mass Screening --- Diagnostic Techniques and Procedures --- Pharmacy Audit --- Audit, Pharmacy --- Pharmacy Audits --- Community Health --- Health, Community --- Preventive Medicine --- Education, Public Health Professional --- Sulfanilic Acids --- Indicator --- Reagent --- Disease. --- Delivery of Health Care.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Radioisotope-based molecular imaging probes provide unprecedented insight into biochemistry and function involved in both normal and disease states of living systems, with unbiased in vivo measurement of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology including functional magnetic resonance imaging (fMRI) can provide such high sensitivity and specificity at a tracer level. The applications of this technology can be very broad ranging from drug development, pharmacokinetics, clinical investigations, and finally to routine diagnostics in radiology. The design and the development of radiopharmaceuticals for molecular imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique challenge. This book is intended for a broad audience and written with the main purpose of educating the reader on various aspects including potential clinical utility, limitations of drug development, and regulatory compliance and approvals.

Radiopharmaceuticals. --- Single-photon emission computed tomography. --- Tomography, Emission. --- Diagnostic imaging --- Molecular diagnosis --- Nuclear medicine --- Tomography, Emission --- Tomography, Emission-Computed --- Indicators and Reagents --- Radionuclide Imaging --- Tomography --- Image Enhancement --- Image Interpretation, Computer-Assisted --- Laboratory Chemicals --- Diagnostic Imaging --- Photography --- Diagnostic Techniques, Radioisotope --- Specialty Uses of Chemicals --- Chemical Actions and Uses --- Diagnostic Techniques and Procedures --- Chemicals and Drugs --- Diagnosis --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Positron-Emission Tomography --- Tomography, Emission-Computed, Single-Photon --- Radiopharmaceuticals --- Medicine --- Health & Biological Sciences --- Radiology, MRI, Ultrasonography & Medical Physics --- Technological innovations --- Molecular diagnosis. --- Radioisotope scanning. --- Radioisotopes in medical diagnosis. --- Diagnostic radioisotopes --- Radiodiagnosis --- Radioisotopes --- Radioisotope scintigraphy --- Radionuclide imaging --- Scintigraphy, Radioisotope --- Molecular diagnostics --- Diagnostic use --- Molecular aspects --- Medicine. --- Radiology. --- Nuclear medicine. --- Cardiology. --- Oncology. --- Neurology. --- Pathology. --- Medicine & Public Health. --- Nuclear Medicine. --- Imaging / Radiology. --- Radioactive tracers --- Radioactivity --- Radioisotopes in medical diagnosis --- Scanning systems --- Molecular biology --- Measurement --- Radiology, Medical. --- Oncology  . --- Nervous system --- Neuropsychiatry --- Heart --- Internal medicine --- Tumors --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Atomic medicine --- Radioisotopes in medicine --- Medical radiology --- Physiological effect --- Neurology . --- Radiological physics --- Physics --- Radiation