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Diabetes --- Metabolic syndrome --- Diabetes Mellitus --- Metabolic Syndrome X. --- Metabolic syndrome. --- Pathophysiology --- physiopathology. --- Pathophysiology. --- Cardiovascular syndrome, Metabolic --- Dysmetabolic syndrome X --- Insulin resistance syndrome --- Metabolic cardiovascular syndrome --- Metabolic syndrome X --- Dysmetabolic Syndrome X --- Metabolic Cardiovascular Syndrome --- Metabolic X Syndrome --- Syndrome X, Insulin Resistance --- Syndrome X, Metabolic --- Insulin Resistance Syndrome X --- Reaven Syndrome X --- Cardiovascular Syndrome, Metabolic --- Cardiovascular Syndromes, Metabolic --- Syndrome X, Dysmetabolic --- Syndrome X, Reaven --- Syndrome, Metabolic Cardiovascular --- Syndrome, Metabolic X --- X Syndrome, Metabolic --- Brittle diabetes --- Diabetes mellitus --- IDDM (Disease) --- Insulin-dependent diabetes --- Ketosis prone diabetes --- Type 1 diabetes --- Metabolic Syndrome. --- Diabetes. --- Metabolism. --- diabetes --- metabolic syndrome --- Insulin resistance --- Metabolism --- Syndromes --- Carbohydrate intolerance --- Endocrine glands --- Diabetic acidosis --- Glycosylated hemoglobin --- Metabolic Syndrome X --- Metabolic Syndromes --- Syndrome, Metabolic --- Syndromes, Metabolic --- Diabetes Mellitus, Type 2 --- Microvascular Angina --- Disorders --- Diseases --- Pathology of the metabolism --- Cardiometabolic Syndrome --- Cardiometabolic Syndromes --- Syndrome, Cardiometabolic --- Syndromes, Cardiometabolic --- Cardiometabolic Risk Factors --- Endocrinologia --- Síndrome metabòlica --- Diabetis

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In today’s world, three great classes of non-infectious diseases – the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders – have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the cellular signaling web operates properly in health and improperly in disease. The stability of the health- and disease-associated states is dynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the past few years an ongoing series of important discoveries have been made that advance our understanding of how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor in all of these disease classes, the appearance of reactive oxygen species as a messenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics including the emergence of small non-coding RNA with important regulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional details integrated into the chapters dealing directly with the diseases. The connections responsible for maintaining stability are explored in depth.

Cellular signal transduction. --- Pathology, Cellular. --- Cellular signal transduction --- Pathology, Cellular --- Biochemical Processes --- Nervous System Diseases --- Cell Physiological Processes --- Metabolic Phenomena --- Insulin Resistance --- Metabolic Diseases --- Biological Science Disciplines --- Diseases --- Cell Physiological Phenomena --- Hyperinsulinism --- Chemical Processes --- Biochemical Phenomena --- Phenomena and Processes --- Nutritional and Metabolic Diseases --- Natural Science Disciplines --- Glucose Metabolism Disorders --- Chemical Phenomena --- Disciplines and Occupations --- Neurodegenerative Diseases --- Neoplasms --- Signal Transduction --- Metabolic Syndrome X --- Physiology --- Metabolism --- Biology --- Medicine --- Health & Biological Sciences --- Biophysics --- Pathology --- Cellular pathology --- Cytopathology --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Physics. --- Human physiology. --- Molecular biology. --- Biochemistry. --- Cell biology. --- Biophysics. --- Biological physics. --- Biomedical engineering. --- Biophysics and Biological Physics. --- Human Physiology. --- Cell Biology. --- Molecular Medicine. --- Biomedical Engineering. --- Biochemistry, general. --- Cytodiagnosis --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Cytology. --- Medicine. --- Biological and Medical Physics, Biophysics. --- Biomedical Engineering and Bioengineering. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Clinical engineering --- Medical engineering --- Bioengineering --- Engineering --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Physicians --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Human body --- Composition --- Health Workforce --- Biological physics --- Physics --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biomolecules --- Systems biology