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There is considerable interest today for the reactions of anticancer metallodrugs with proteins as these interactions might feature processes that are crucial for the biodistribution, the toxicity and even the mechanism of action of this important group of anticancer agents. Valuable structural and functional information on these adducts could be derived from several biophysical studies mainly relying on the application of X-ray diffraction and ESI MS techniques. The structural and functional information achieved on the respective metallodrug-protein adducts allowed us to identify some general trends in the reactivity of anticancer metallodrugs with protein targets.

Life sciences.

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This book in the highly respected Cambridge History of Science series is devoted to the history of the life and earth sciences since 1800. It provides comprehensive and authoritative surveys of historical thinking on major developments in these areas of science, on the social and cultural milieus in which the knowledge was generated, and on the wider impact of the major theoretical and practical innovations. The articles are written by acknowledged experts who provide concise accounts of the latest historical thinking coupled with guides to the most important recent literature. In addition to histories of traditional sciences, the book covers the emergence of newer disciplines such as genetics, biochemistry and geophysics. The interaction of scientific techniques with their practical applications in areas such as medicine is a major focus of the book, as is its coverage of controversial areas such as science and religion, and environmentalism.

Earth sciences. --- Life sciences.

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Life sciences --- Engineering --- Matter

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Life sciences --- Engineering --- Matter --- Engineering. --- Life sciences. --- Matter.

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Life sciences --- Engineering --- Matter --- Engineering. --- Life sciences. --- Matter.