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Hepatitis C.

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The book details the synthesis of molecules designed to inhibit the hepatitis C virus (HCV) NS3 serine protease and the human aspartic protease BACE-1. It explores the relationships between potential inhibitors and the targeted enzymes while discussing the class of enzymes known as proteases. The book also discusses why such enzymes can be regarded as suitable targets for developing drugs to combat diseases. It presents the results of the design and synthesis of linear and macrocyclic NS3 protease inhibitors containing a novel trisubstituted cyclopentane moiety as an N-acyl-(4 bioisostere. The book is intended for researchers and students in the field of medicinal chemistry and drug design.

Aspartic Proteinases. --- Hepatitis C Virus. --- Enzyme Inhibitors.

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Chronic viral hepatitis affect hundreds of millions of people worldwide, and each year millions more people become infected. In Chronic Viral Hepatitis, Second Edition, a panel of distinguished clinicians and clinical investigators build upon the first edition by comprehensively reviewing all the relevant new information regarding resistance, side effects, and therapies for chronic viral hepatitis. The text covers recent advances in the understanding of pathogenesis of viral hepatitis while discussing promising agents in development for its treatment. The authors devote special attention to reactivation of hepatitis B with chemotherapy and immunosuppression, herbal and non-traditional therapies, chronic viral hepatitis in the pediatric population, and immunology and immunotherapy of HCV and provide relative costs for all diagnostic and therapeutic options. Authoritative and up-to-date, Chronic Viral Hepatitis, Second Edition offers today's gastroenterologists, internists, hepatologists, and infectious disease specialists a practical guide to the recognition, diagnosis and treatment of chronic viral hepatitis from a multidisciplinary approach.

Hepatitis B virus -- Physiological effect. --- Hepatitis C virus -- Physiological effect. --- Hepatitis, Viral -- Treatment. --- Hepatitis, Viral. --- Hepatitis, Viral --- Hepatitis B virus --- Hepatitis C virus --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Hepatitis --- Virus Diseases --- Disease Attributes --- Pathologic Processes --- Liver Diseases --- Diseases --- Pathological Conditions, Signs and Symptoms --- Digestive System Diseases --- Hepatitis, Viral, Human --- Diagnosis --- Chronic Disease --- Medicine --- Health & Biological Sciences --- Gastroenterology --- Treatment --- Physiological effect --- Liver --- Viral hepatitis --- Virus hepatitis --- Diseases. --- Medicine. --- Gastroenterology. --- Medicine & Public Health. --- Internal medicine --- Digestive organs --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Virus diseases --- Gastroenterology .

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In Verslavingsgeneeskunde worden problemen van patiënten besproken uit de praktijk van de verslavingsarts, problemen die niet direct met behulp van een richtlijn zijn op te lossen. Het is een boek dat de praktijk van de behandeling en begeleiding van verslaafde patiënten combineert met wetenschappelijke inzichten over verslaving en behandeling. De problematiek van een patiënt wordt op systematische wijze in kaart gebracht volgens de EBM-methode, en de daaruit voortkomende vragen worden zo goed mogelijk beantwoord.

Verslaving --- Neurofarmacologie --- Geneesmiddelenverslaving --- 602.4 --- Geneeskunde --- Psychiatrie --- 614.7 --- ADHD (Attention Deficit Hyperactivity Disorder, hyperkinetisch syndroom, MBD) --- alcoholisme --- alexithymie --- angststoornissen --- borderlinesyndroom --- cannabis --- cocaïne --- collocatie --- diabetes mellitus (suikerziekte) --- drugs --- dwangbehandeling --- dwangstoornis (obsessief-complusieve stoornis) --- ecstasy --- evidence-based onderzoek (evidence-based medicine) --- gedwongen opname (BOPZ) --- hepatitis C --- medicamenteuze verslaving --- mentaal gehandicapten --- neurobiologie --- opiaten --- posttraumatische stressstoornis --- psychofarmaca --- roken --- schizofrenie --- slaapstoornissen --- verslaving --- (zie ook: alvleesklier, insuline) --- (zie ook: farmacologie, psychofarmaca) --- (zie ook: zwakzinnigheid) --- Psychiatry --- psychopathologie --- Toxicology --- psychosomatiek --- evidence-based methodiek --- PTSS (posttraumatische stress-stoornis) --- farmacologie --- Pharmacology. Therapy --- Gokken --- Internet