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In human solid tumors, nodal status is the most important prognostic indicator for patient outcome. Recent developments in the sentinel lymph node concept have resulted in new procedures to define the first draining node as the primary gateway through which the cancer will spread. In From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System, a panel of international authorities takes an in-depth look at the role of the lymphovascular system in the spread of cancer. The authors summarize the findings of the Second International Symposium on Cancer Metastasis: Basis for Rational Therapy summit. Specifically, the book presents important developments in the biology and clinical understanding of cancer metastasis, describes the relationship between tumor microenvironment and proliferation, and defines the process of lymphangiogenesis and angiogenesis with special reference to cancer metastasis. From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System provides oncologists, radiologists, and cancer researchers the necessary information to study and develop new strategies to curb the process of metastasis.

Lymphatic Metastasis -- Congresses. --- Metastasis. --- Oncology --- Medicine --- Health & Biological Sciences --- Metastasis --- Lymphangiogenesis --- Congresses --- Neovascularization, Pathologic --- Neoplasm Invasiveness --- Antineoplastic Combined Chemotherapy Protocols --- Lymphatic Metastasis --- Organogenesis --- Neoplasm Metastasis --- Publication Formats --- Antineoplastic Protocols --- Neoplastic Processes --- Metaplasia --- Drug Therapy, Combination --- Pathologic Processes --- Embryonic and Fetal Development --- Clinical Protocols --- Publication Characteristics --- Neoplasms --- Drug Therapy --- Morphogenesis --- Therapeutics --- Pathological Conditions, Signs and Symptoms --- Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Growth and Development --- Physiological Processes --- Physiological Phenomena --- Phenomena and Processes --- Lymphatic metastasis. --- Oncology. --- Medicine. --- Radiotherapy. --- Pathology. --- Surgical oncology. --- Medicine & Public Health. --- Surgical Oncology. --- Tumors --- Lymphatics --- Cancer --- Oncology  . --- Disease (Pathology) --- Medical sciences --- Medicine, Preventive --- Radiation therapy --- Electrotherapeutics --- Hospitals --- Medical electronics --- Medical radiology --- Therapeutics, Physiological --- Phototherapy --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Radiological services --- Excision --- Treatment --- Cancer metastasis --- Lymphovascular system

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Within the last decade there have been a number of new and important areas of emphasis in HIV care and research, particularly in the context of brain involvement. Without question, clinical and research innovations in the modern era of the HIV pandemic warrant an update on HIV and the brain. Written by a panel of leading experts, HIV and the Brain: New Challenges in the Modern Era offers a clear picture of brain impairment associated with the virus with particular focus on three emerging areas including different genetic strains of the virus throughout the world, interactions between advanced age and HIV, and the impact of HIV on the brain in the context of chronic, long-term treatment with highly active antiretroviral therapy (HAART). HIV and the Brain: New Challenges in the Modern Era provides a comprehensive review of both basic science and clinical implications in these important areas of the disease. The text is of particular relevance to both research scientists and clinicians involved in HIV in the modern era.

AIDS (Disease) --Complications. --- Brain --Diseases. --- HIV (Viruses). --- Neurologic manifestations of general diseases. --- AIDS (Disease) --- HIV (Viruses) --- Neurologic manifestations of general diseases --- Brain --- Lentivirus Infections --- Delirium, Dementia, Amnestic, Cognitive Disorders --- Dementia --- Immunologic Deficiency Syndromes --- Drug Therapy, Combination --- Sexually Transmitted Diseases, Viral --- Central Nervous System --- Drug Therapy --- Nervous System --- Sexually Transmitted Diseases --- Brain Diseases --- Immune System Diseases --- Retroviridae Infections --- Mental Disorders --- Central Nervous System Diseases --- RNA Virus Infections --- Anatomy --- Diseases --- Therapeutics --- Virus Diseases --- Psychiatry and Psychology --- Nervous System Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Antiretroviral Therapy, Highly Active --- HIV Infections --- AIDS Dementia Complex --- Cognition Disorders --- Medicine --- Health & Biological Sciences --- Clinical Immunology --- Neurology --- Complications --- Complications. --- Diseases. --- Brain diseases --- Neurologic symptoms of general diseases --- Neurological manifestations of general diseases --- AIDS-associated retrovirus --- AIDS virus --- ARV (Viruses) --- HTLV-III (Viruses) --- HTLV-III-LAV (Viruses) --- Human immunodeficiency viruses --- Human T-cell leukemia virus III --- Human T-cell lymphotropic virus III --- Human T-lymphotropic virus III --- IDAV (Viruses) --- Immunodeficiency-associated virus --- LAV (Viruses) --- LAV-HTLV-III (Viruses) --- Lymphadenopathy-associated virus --- T-lymphotrophic virus III, Human --- Medicine. --- Immunology. --- Internal medicine. --- Infectious diseases. --- Neurology. --- Pain medicine. --- Medicine & Public Health. --- Infectious Diseases. --- Internal Medicine. --- Pain Medicine. --- Nervous system --- Symptoms --- HTLV (Viruses) --- Virus-induced immunosuppression --- Psychology, Pathological --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Immunobiology --- Life sciences --- Serology --- Medicine, Internal --- Neuropsychiatry --- Algiatry --- Neurology .