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Receptors, TNF-Related Apoptosis-Inducing Ligand --- TNF-Related Apoptosis-Inducing Ligand --- Uterine Cervical Neoplasms --- Uterine Cervical Neoplasms --- analysis --- pharmacology --- radiotherapy --- therapy
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Since the causal role of Human PapillomaVirus (HPV) has been firmly established in all cancers of the uterine cervix, scientists have been looking for a vaccine as a preventive strategy for this type of cancer.
There are two HPV vaccines availables on the market today, produced independently by Merck & Co and GlaxoSmithKline. This dissertation mainly focuses on the first vaccine sold, the Gardasil®. It’s a quadrivalent HPV-6/11/16/18 vaccine that has shown a very high rate of protection against cervical lesions and ano-genital warts. Despite a lasting and reliable protection against the types of the virus that are included in the vaccine, sceening for precancerous lesions by Pap Test is always recommended for maintenance of general health.
Clinical development is now in an advanced stage and the main results are highlighted in this work. Results are detailed for different groups of the population and test various parameters such as efficacity, immunogenicity and adverse effects, amongst others.
On the basis of these results, it is concluded that vaccination must be promoted for young girls after a consideration of the scale benefits versus risks was found to be quite favorable.
Moreover, an economic analysis has also been made in this work.
Recently, the age range of girls who can profit from the repayment scheme was widened: currently it includes girls from 12 to 18 years old. This change in policy is anticipated to lead to a higter vaccinal coverage rate.
To finish, a chapter focuses on a comparison of differents characteristics of the two competiting vaccines.
This work has been undertaken in order to gather and synthesize the available information about HPV infections prevention. It is hoped that its content will constitutes a clear and practical compilation to answer questions of healthy body Depuis que le rôle causal du papillomavirus humain (HPV) a été établi dans tous les cancers du col de l’utérus, les scientifiques se sont tournés vers la recherche d’un vaccin comme moyen préventif contre ce type de cancer.
A l’heure actuelle, il existe 2 vaccins anti-HPV sur le marché, produits indépendamment par Merck & Co et GlaxosmithKline. Ce mémoire se concentre principalement sur le premier vaccin commercialisé, le Gardasil®. C’est un vaccin quadrivalent anti-HPV 6/11/16/18 qui a montré un taux de protection très élevé contre les lésions utérines et les verrues ano-génitales. Malgré une protection sûre et durable contre les types de virus inclus dans le vaccin, le dépistage des lésions précancéreuses par frottis est toujours recommandé par les professionnels de la santé.
Les essais cliniques sont maintenant à un stade avancé et les principaux résultats sont décrits dans ce travail. Les résultats sont détaillés pour différents groupes de population et reprennent des paramètres variés tels que l’efficacité, l’immunogénicité, les effets secondaires etc…
Sur base de ces résultats, on peut conclure que la vaccination est à encourager chez les jeunes filles après l’examen d’un rapport bénéfices / risques tout à fait favorable.
D’autre part, une analyse économique a également été effectuée dans ce travail.
Récemment, la tranche d’âge des filles pouvant profiter du remboursement a été élargie, cela concerne maintenant les filles de 12 à 18 ans. Cette bonne nouvelle conduira à un taux de couverture vaccinale plus important.
Pour terminer, un chapitre se concentre sur la comparaison des différentes caractéristiques des 2 vaccins concurrents.
Ce travail a été réalisé dans le but de rassembler et de synthétiser l’information disponible relative à la prévention des infections dues aux HPV. De la sorte, son contenu pourra constituer un recueil clair et pratique pour répondre aux questions des professionnels de la santé.
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As compared with cytology's use in other organ systems, direct cytological examination of the endometrium is not a widely practiced diagnostic procedure. This volume highlights endometrial cytology as an effective method for ensuring endometrial normalcy and discovering and diagnosing malignant and premalignant states. Endometrial Cytology with Tissue Correlations covers the background, collection technique, diagnostic criteria and pitfalls, as well as reliability of endometrial cytology. This volume, part of the Essentials in Cytopathology book series, fits into the lab coat pocket and is ideal for portability and quick reference. Each volume in the series is heavily illustrated with a full color art program, while the text follows a user-friendly outline format. John A. Maksem, M.D., is Director of Cytopathology, Orlando Health, Orlando, Florida. Stanley J. Robboy, M.D., is Head of Gynecologic & Obstetrical Pathology, Department of Pathology, Duke University Medical Center, Durham, North Carolina. John W. Bishop, M.D., is HS Clinical Professor of Pathology, University of California, Davis, Sacramento, California. Isabelle Meiers, M.D., is Head of Cytology at University Hospital Lewisham, London, United Kingdom. .
Cervix Uteri -- microbiology. --- Cytodiagnosis -- methods. --- Endometrial Neoplasms -- diagnosis. --- Generative organs, Female -- Cancer -- Cytopathology. --- Generative organs, Female -- Cytopathology. --- Uterine Cervical Neoplasms -- diagnosis. --- Endometrium --- Laboratory Techniques and Procedures --- Uterine Neoplasms --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Uterus --- Uterine Diseases --- Genital Neoplasms, Female --- Genitalia, Female --- Urogenital Neoplasms --- Genitalia --- Genital Diseases, Female --- Urogenital System --- Female Urogenital Diseases --- Neoplasms by Site --- Female Urogenital Diseases and Pregnancy Complications --- Neoplasms --- Anatomy --- Diseases --- Diagnosis --- Methods --- Endometrial Neoplasms --- Cytodiagnosis --- Medicine --- Health & Biological Sciences --- Pathology --- Oncology --- Cytology --- Endometriosis. --- Pathology. --- Disease (Pathology) --- Adenomyosis --- Medicine. --- Medicine & Public Health. --- Medical sciences --- Medicine, Preventive --- Generative organs, Female --- Pelvis
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