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Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson's disease, multiple sclerosis, Alzheimer's disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.

Adenosine --- Adenosinrezeptor --- Pharmacokinetics. --- Purinergic P1 Receptor Antagonists. --- Receptors, Purinergic P1 --- Receptors. --- Pathophysiologie --- Physiologie --- therapeutic use.

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The Local Cardiac Renin-Angiotensin Aldosterone System, Second Edition updates new findings on the local renin-angiotensin systems (RAS) with a focus on the local RAASs of the cardiovascular system and kidney. Edward D. Frohlich, M.D., M.A.C.P, F.A.C.C., is the Alton Ochsner Distinguished Scientist at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Professor of Medicine and of Physiology at Louisiana State University School of Medicine, New Orleans, and Clinical Professor of Medicine and Adjunct Professor of Pharmacology at Tulane University School of Medicine, New Orleans. He is past Editor-in-Chief of the American Heart Association journal HYPERTENSION. Richard N. Re, M.D., is the Section Head, Hypertension at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Ochsner's Scientific Director of Research.

Heart -- Physiology. --- Renal hypertension. --- Renin. --- Renin-angiotensin system. --- Renin-angiotensin system --- Hypertension --- Renal hypertension --- Metabolism --- Congresses --- Vacuolar Proton-Translocating ATPases --- Receptors, Cell Surface --- Physiology --- Renin-Angiotensin System --- Proton-Translocating ATPases --- Hemodynamics --- Metabolic Phenomena --- Vascular Diseases --- Publication Formats --- Biological Science Disciplines --- Membrane Proteins --- Natural Science Disciplines --- Publication Characteristics --- ATP Synthetase Complexes --- Cardiovascular Diseases --- Cardiovascular Physiological Processes --- Proteins --- Proton Pumps --- Adenosine Triphosphatases --- Phenomena and Processes --- Diseases --- Disciplines and Occupations --- Cation Transport Proteins --- Acid Anhydride Hydrolases --- Phosphotransferases (Phosphate Group Acceptor) --- Amino Acids, Peptides, and Proteins --- Cardiovascular Physiological Phenomena --- Circulatory and Respiratory Physiological Phenomena --- Chemicals and Drugs --- Phosphotransferases --- Ion Pumps --- Hydrolases --- Transferases --- Membrane Transport Proteins --- Enzymes --- Enzymes and Coenzymes --- Carrier Proteins --- Animal Biochemistry --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Heart --- Physiology. --- RA system --- RAA system --- RAAS (Physiology) --- RAS (Physiology) --- Renin-angiotensin-aldosterone axis --- Renin-angiotensin-aldosterone system --- Medicine. --- Cardiology. --- Endocrinology. --- Medicine & Public Health. --- Aldosterone --- Angiotensins --- Renin --- Water-electrolyte balance (Physiology) --- Blood pressure --- Regulation --- Internal medicine --- Hormones --- Endocrinology .