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Book
Molecular Mechanisms of Bacterial Infection via the Gut
Author:
ISBN: 3642261124 3642018459 9786612509179 1282509179 3642018467 Year: 2009 Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer,

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Abstract

Our gut is colonized by numerous bacteria throughout our life, and the gut epithelium is constantly exposed to foreign microbes and dietary antigens. Thus, the gut epithelium acts as a barrier against microbial invaders and is equipped with various innate defense systems. Resident commensal and foreign invading bacteria interact intimately with the gut epithelium and can impact host cellular and innate immune responses. From the perspective of many pathogenic bacteria, the gut epithelium serves as an infectious foothold and port of entry for disseminate into deeper tissues. In some instances when the intestinal defense activity and host immune system become compromised, even commensal and opportunistic pathogenic bacteria can cross the barrier and initiate local and systematic infectious diseases. Conversely, some highly pathogenic bacteria, such as those highlighted in this book, are able to colonize or invade the intestinal epithelium despite the gut barrier function is intact. Therefore, the relationship between the defensive activity of the intestinal epithelium against microbes and the pathogenesis of infective microbes becomes the basis for maintaining a healthy life. The authors offer an overview of the current topics related to major gastric and enteric pathogens, while highlighting their highly evolved host (human)-adapted infectious processes. Clearly, an in-depth study of bacterial infectious strategies, as well as the host cellular and immune responses, presented in each chapter of this book will provide further insight into the critical roles of the host innate and adaptive immune systems and their importance in determining the severity or completely preventing infectious diseases. Furthermore, under the continuous threat of emerging and re-emerging infectious diseases, the topic of gut-bacteria molecular interactions will provide various clues and ideas for the development of new therapeutic strategies.

Keywords

Bacterial diseases --Molecular aspects. --- Gastrointestinal system --Diseases. --- Molecular microbiology. --- Bacterial diseases --- Gastrointestinal system --- Molecular microbiology --- Adaptive Immunity --- Bacterial Infections --- Intestines --- Immunity, Innate --- Microbiology --- Bacterial Infections and Mycoses --- Gastrointestinal Tract --- Biology --- Immunity --- Immune System Phenomena --- Diseases --- Digestive System --- Biological Science Disciplines --- Natural Science Disciplines --- Phenomena and Processes --- Anatomy --- Disciplines and Occupations --- Microbiology & Immunology --- Health & Biological Sciences --- Molecular aspects --- Bacterial diseases. --- Infections. --- Bacterial infections --- Gastro-intestinal system --- Gastrointestinal tract --- GI tract --- Tract, Gastrointestinal --- Tract, GI --- Medicine. --- Immunology. --- Medical microbiology. --- Molecular biology. --- Biomedicine. --- Medical Microbiology. --- Molecular Medicine. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Communicable diseases --- Medical bacteriology --- Pathogenic bacteria --- Alimentary canal --- Digestive organs --- Microbiology. --- Microbial biology --- Microorganisms --- Health Workforce --- Medicine --- Biomedical Research. --- Research. --- Biological research --- Biomedical research


Book
Crossroads between Innate and Adaptive Immunity II
Authors: --- --- ---
ISBN: 0387793100 1441927182 9786611927172 1281927171 0387793119 Year: 2009 Publisher: New York, NY : Springer New York : Imprint: Springer,

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Abstract

Aegean Conferences is an independent, nonprofit, educational organization directed and managed by the scientific community. The board is made up of nine researchers/scientists in various disciplines from Harvard, Brown, University of Pennsylvania, UCSD, Princeton, Biovista and the Foundation for Biomedical Research Academy of Athens. The board both invites and approves unsolicited proposals for Conferences in all fields of Science, Engineering, Arts, and Humanities. The purpose of the Conferences is to bring together individuals with common interests to examine the emerging and most advanced aspects of their particular field. This volume will include mini-reviews derived from work to be presented at the Aegean Conference: Second Crossroads between Innate and Adaptive Immunity, in Crete, Greece, June 17-22, 2007. This meeting is designed to serve as a forum to discuss the most recent progress in complement research as it pertains to human disease pathogenesis and therapeutics. The rapid pace of development in complement basic research and the advent and application of new experimental approaches in this field have now allowed us to take an integrated view of the in vivo biology of the complement system. The availability of new reagents (e.g. synthetic and recombinant inhibitors) and animal models (e.g. transgenic and knockout mice) has enabled us to address, in an in vivo setting, its involvement in various pathophysiological conditions. Such studies are shedding new light on the pathogenetic mechanism of complement-related diseases such as autoimmune diseases and inflammatory tissue damage as well as defining new areas of high interest such as the developmental biology of complement. They also provide the basis for developing new therapeutic strategies for these diseases through manipulation of in vivo complement activity. This volume will serve as a resource where the latest development in these specific areas will be discussed in a more focused and detailed manner.

Keywords

Immune response --Regulation --Congresses. --- Natural immunity --Congresses. --- Natural immunity --- Immune response --- Biological Science Disciplines --- Immunity --- Immune System Processes --- Adaptive Immunity --- Publication Formats --- Immunity, Cellular --- Publication Characteristics --- Immune System Phenomena --- Natural Science Disciplines --- Disciplines and Occupations --- Phenomena and Processes --- Immunity, Innate --- Physiology --- Antigen Presentation --- Immunity, Active --- Congresses --- Medicine --- Biology --- Health & Biological Sciences --- Medical Research --- Microbiology & Immunology --- Regulation --- Disease resistance --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- Medicine. --- Immunology. --- Pharmacology. --- Infectious diseases. --- Biochemistry. --- Microbiology. --- Biomedicine. --- Infectious Diseases. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Microbial biology --- Microorganisms --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Pathology --- Physicians --- Composition --- Physiological effect --- Emerging infectious diseases. --- Toxicology. --- Pharmacology --- Poisoning --- Poisons --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Toxicology

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