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Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. "The Kinetochore: from Molecular Discoveries to Cancer Therapy" edited by Peter De Wulf and William C. Earnshaw presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and "model" eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs.

Cancer -- Therapy. --- Cell organelles. --- Chromosomes. --- Chromosomes --- Cell organelles --- Genetic Processes --- Cell Proliferation --- Cell Cycle --- Centromere --- Therapeutic Uses --- Diseases --- Cell Physiological Processes --- Pharmacologic Actions --- Genetic Phenomena --- Cell Growth Processes --- Chromosome Structures --- Growth --- Cell Physiological Phenomena --- Genetic Structures --- Phenomena and Processes --- Chemical Actions and Uses --- Chemicals and Drugs --- Growth and Development --- Intranuclear Space --- Cell Nucleus Structures --- Physiological Processes --- Cell Nucleus --- Physiological Phenomena --- Intracellular Space --- Cellular Structures --- Cells --- Anatomy --- Cell Division --- Antineoplastic Agents --- Neoplasms --- Kinetochores --- Biology --- Health & Biological Sciences --- Cytology --- Chromosome theory --- Organelles, Cell --- Medicine. --- Cancer research. --- Human genetics. --- Medical microbiology. --- Molecular biology. --- Virology. --- Cell biology. --- Biomedicine. --- Cancer Research. --- Cell Biology. --- Medical Microbiology. --- Molecular Medicine. --- Human Genetics. --- Cell nuclei --- Crossing over (Genetics) --- Cytotaxonomy --- Genetics --- Karyokinesis --- Linkage (Genetics) --- Cytoplasm --- Oncology. --- Cytology. --- Microbiology. --- Medical virology. --- Medical microbiology --- Virology --- Virus diseases --- Heredity, Human --- Human biology --- Physical anthropology --- Clinical sciences --- Medical profession --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Microbial biology --- Microorganisms --- Cell biology --- Cellular biology --- Cytologists --- Tumors --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Microbiology --- Cancer research