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Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered
Hyaluronic acid --- Carcinogenesis. --- Pathophysiology. --- Cancer --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathology --- Genetic toxicology --- Hyaluronan --- Mucopolysaccharides --- Organic acids --- Pathogenesis --- Hyaluronic acid - Pathophysiology --- Carcinogenesis
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Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal. The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer. Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer. Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination.
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This book brings together a collection of papers that Robert M Stern and his co-authors have written in recent years. The collection addresses a variety of issues pertinent to the global trading system. One group of papers deals with globalization in terms of what the public needs to know about this phenomenon and the role of the World Trade Organization (WTO), whether some countries may be hurt by globalization, how global market integration relates to national sovereignty, and how and whether considerations of fairness are and should be dealt with in the global trading system and WTO negotiation
Commercial policy. --- Foreign trade regulation. --- Free trade. --- Globalization -- Economic aspects. --- International trade. --- United States -- Commercial policy. --- International trade --- Globalization --- Free trade --- Foreign trade regulation --- Commercial policy --- International Commerce --- Commerce --- Business & Economics --- Economic aspects --- Economic aspects. --- United States --- Foreign trade policy --- International trade policy --- Trade policy --- Export and import controls --- Foreign trade control --- Import and export controls --- International trade control --- International trade regulation --- Prohibited exports and imports --- Free trade and protection --- Trade, Free --- Trade liberalization --- External trade --- Foreign commerce --- Foreign trade --- Global commerce --- Global trade --- Trade, International --- World trade --- Government policy --- Law and legislation --- Economic policy --- International economic relations --- Trade regulation --- Non-traded goods --- 331.31 --- 337.50 --- 339.113 --- 382.11 --- 382.30 --- AA / International- internationaal --- Economisch beleid --- Douanebeleid. Douaneovereenkomsten en -unies: algemeenheden. Economische sancties --- Buitenlandse investeringen --- Theorie van het internationale evenwicht. Economische onafhankelijkheid van een natie. Globalisering. Mondialisering --- Handels- en wisselpolitiek in hun verband met de buitenlandse handel: algemeenheden
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Hegel, Georg W.F. --- Metaphysics --- History. --- Hegel, Georg Wilhelm Friedrich, --- Hēgeru, --- Hei-ko-erh, --- Gegelʹ, Georg, --- Hījil, --- Khegel, --- Hegel, G. W. F. --- Hegel, --- Hei Ge Er, --- Chenkel, --- Hīghil, --- הגל --- הגל, גאורג וילהלם פרידריך, --- הגל, גיאורג וילהלם פרידריך, --- הגל, ג.ו.פ, --- היגל, גורג ווילהלם פרדריך, --- היגל, גיורג וילהלם פרידריך, --- 黑格尔, --- Hegel, Guillermo Federico, --- Hegel, Jorge Guillermo Federico, --- הגל, --- Heyel, Georg Wilhelm Friedrich, --- Higil, Gʼūrg Vīlhim Frīdrīsh, --- هگل, --- هگل، گئورگ ويلهم فريدريش, --- History --- Hegel, Giorgio Guglielmo Frederico --- Hegel, Georg Wilhelm Friedrich --- Hegel, Georg Wilhelm Friedrich.
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Architecture, Postmodern. --- Modern movement (Architecture).
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Architects --- Architecture --- History --- Johnson, Philip, --- Criticism and interpretation. --- 72.07 --- 72(73) --- Architectuur ; 20ste eeuw ; Philip Johnson --- Johnson, Philip 1906-2005 (°Cleveland, Ohio, Verenigde Staten) --- Woningbouw ; Verenigde Staten --- 72.036 <73> --- 72.039 --- 72.039 Hedendaagse architectuur. Bouwkunst sinds 1960 --- Hedendaagse architectuur. Bouwkunst sinds 1960 --- Architecture, Modern --- 72.036 <73> Moderne bouwkunst. Architectuur van de 20e eeuw--Verenigde Staten van Amerika. VSA. USA --- Moderne bouwkunst. Architectuur van de 20e eeuw--Verenigde Staten van Amerika. VSA. USA --- Architecten. Stedenbouwkundigen A - Z --- Architectuur ; Verenigde Staten van Amerika --- Johnson, Philip Cortelyou,
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Architecture --- -Architecture, Modern --- -New York (N.Y.) --- -Buildings, structures, etc --- -History
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