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In 1865, Gregor Mendel presented "Experiments in Plant-Hybridization," the results of his eight-year study of the principles of inheritance through experimentation with pea plants. Overlooked in its day, Mendel's work would later become the foundation of modern genetics. Did his pioneering research follow the rigors of real scientific inquiry, or was Mendel's data too good to be true-the product of doctored statistics?In Ending the Mendel-Fisher Controversy, leading experts present their conclusions on the legendary controversy surrounding the challenge to Mendel's findings by British statistician and biologist R. A. Fisher. In his 1936 paper "Has Mendel's Work Been Rediscovered?" Fisher suggested that Mendel's data could have been falsified in order to support his expectations. Fisher attributed the falsification to an unknown assistant of Mendel's. At the time, Fisher's criticism did not receive wide attention. Yet beginning in 1964, about the time of the centenary of Mendel's paper, scholars began to publicly discuss whether Fisher had successfully proven that Mendel's data was falsified. Since that time, numerous articles, letters, and comments have been published on the controversy.This self-contained volume includes everything the reader will need to know about the subject: an overview of the controversy; the original papers of Mendel and Fisher; four of the most important papers on the debate; and new updates, by the authors, of the latter four papers. Taken together, the authors contend, these voices argue for an end to the controversy-making this book the definitive last word on the subject.

Mendel, Gregor, 1822-1884 --- Genetics --- Hybridization, Vegetable --- History, Modern --- Hybridization --- Science --- History

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Matter --- Philosophers --- Philosophy --- Philosophy and science --- Species --- Speciation (Biology) --- Biology --- Genetics --- Hybridization --- Organisms --- Science and philosophy --- Science --- Mental philosophy --- Humanities --- Gilson, Etienne --- Gilson, E. --- Gilson, Étienne Henry, --- Gilson, Stefan,

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Larve de poisson --- Fish larvae --- Aquaculture --- aquaculture --- Micro-organisme --- microorganisms --- Rotifera --- Artemia --- Alimentation des poissons --- Fish feeding --- Probiotique --- probiotics --- Contrôle de maladies --- Disease control --- Sciences and engineering --- biological sciences --- biology --- microbiology --- 639.3.03 --- 579.264 --- 639.3.043 --- Reproductive processes of fish. Propagation of fish. Hybridization. Fertilization. Egg-laying. Fish eggs and larvae --- Antagonism. Probiotics --- Feeding, nutrition of fish. Fish foods --- 639.3.043 Feeding, nutrition of fish. Fish foods --- 579.264 Antagonism. Probiotics --- 639.3.03 Reproductive processes of fish. Propagation of fish. Hybridization. Fertilization. Egg-laying. Fish eggs and larvae --- microbiology. --- aquaculture. --- Brachionus Plicatilis --- Prébiotique --- Biological sciences --- Biology --- Microbiology.

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Hydrangea --- Hibiscus --- Buddleja --- Hybridation interspécifique --- Interspecific hybridization --- 631.52 --- 635.9 --- Improvement of plant strains. Applied genetics. Selection etc. --- Ornamentals. Decorative plants. Ornamental gardening --- Sciences and engineering --- biological sciences --- biology --- botany --- genetics --- agriculture --- plant culture --- 635.9 Ornamentals. Decorative plants. Ornamental gardening --- 631.52 Improvement of plant strains. Applied genetics. Selection etc. --- botany. --- genetics. --- plant culture. --- Biological sciences --- Biology --- Botany. --- Genetics. --- Agriculture --- Plant culture. --- Plant breeding --- Research --- Ornamental woody plants --- Kweken

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The book is of interest to academic and industrial researchers but also clinicians who are working on inflammation related topics and would like to extend their knowledge about microarrays and the application thereof. After reading the book a researcher or clinician should be in the position to plan, perform and analyse or to critically review microarray experiments related to inflammation research. So far, non of the published books covers all aspects which need to be taken into account when planning and performing a microrray experiment in inflammation research. Normally, for a researcher or clinician doing a microarray experiment it is not enough to have knowledge about microarrays , as the experiment does not start with purified and quality controlled RNA and does not end with signal intensities. Things like appropriate cell sorting techniques, stabilisation and transport of RNA or cells, the knowledge how to deal with whole blood as well as options for automation are crucial for a successful application of microarrays. Moreover these aspects are the main obstacles for transferring microarray based inflammation analysis from bench to bedside and the limiting factors for higher through put as needed in multicenter studies.

Biomedicine. --- Microarrays. --- Immunology. --- Cell Biology. --- Hematology. --- Biotechnology. --- Pharmacology/Toxicology. --- Medicine. --- DNA microarrays. --- Toxicology. --- Cytology. --- Médecine --- Puces à ADN --- Immunologie --- Toxicologie --- Biotechnologie --- Hématologie --- Cytologie --- Inflammation -- Pathophysiology. --- Inflammation -- Physiopathology. --- Oligonucleotide array sequence analysis. --- Inflammation --- DNA microarrays --- Oligonucleotide Array Sequence Analysis --- Gene Expression Profiling --- Microarray Analysis --- Pathologic Processes --- Genetic Techniques --- Molecular Probe Techniques --- Nucleic Acid Hybridization --- Sequence Analysis --- Microchip Analytical Procedures --- Pathological Conditions, Signs and Symptoms --- Investigative Techniques --- Chemistry Techniques, Analytical --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Diseases --- Biomedical Engineering --- Pathology --- Health & Biological Sciences --- Medicine --- Pathophysiology --- Pathophysiology. --- DNA biochips --- Microarrays, DNA --- Inflammatory process --- Pharmacology. --- Cell biology. --- Biochips --- Immobilized nucleic acids --- Anti-inflammatory agents --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Chemical engineering --- Genetic engineering --- Haematology --- Internal medicine --- Blood --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Immunobiology --- Life sciences --- Serology --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect