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Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.
Cell receptors. --- Natural immunity. --- Disease resistance --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- Immunity --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Proteins
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Shows that the structural similarity of the Multichain Immune Recognition Receptors (MIRRs) determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms. This book provides the basis for existing and future therapeutic strategies targeting MIRRs.
Immune recognition. --- T cells --- Killer cells. --- Cellular signal transduction. --- Cell receptors. --- Receptors. --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- K cells --- Natural killer cells --- NK cells --- Immunocompetent cells --- Cell-mediated cytotoxicity --- T cell receptors --- T lymphocyte antigen receptors --- Cell receptors --- Antigen recognition --- Immunorecognition --- Recognition, Immune --- Immune response --- Immunospecificity --- Oncology . --- Medicine. --- Life sciences. --- Oncology. --- Biomedicine general. --- Life Sciences, general. --- Tumors --- Biosciences --- Sciences, Life --- Science --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biomedicine, general. --- Health Workforce
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