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The articles in this volume have been selected to demonstrate the progress in the development of human antibody therapeutics for viral disease. Keck et al. review the nature of the immune response to the Hepatitis C virus (HCV) and the details of viral neutralization by antibodies, providing a conceptual model for the clinical use of HCV-specific antibodies. Huber et al. summarize the initial clinical experiences with antibody therapeutics for Human Immunodeficiency Virus that can be targeted to either the HIV virion or to host cell proteins. A discussion of the breadth immune strategies that is required to control human rabies is provided by Nagarajan et al., with a particular focus on India and other countries in which rabies is endemic. The development of pavilizumab for RSV prophylaxis is reviewed in Wu et al., in addition to results of antibody optimization studies that provide surprising insights and have broad general implications for anti-viral antibody engineering. Melhop and Diamond explicate the biology of West Nile Virus as a general model for flaviviruses, while using their cloned antibodies as a springboard to consider the mechanisms of WNV neutralization. The volume concludes with a description of methods to clone human antibodies in their native configurations, which access a class of antibodies that differ from those obtained by recombinant DNA or transgenic mouse methods. The articles in this volume are definitive and comprehensive reviews written by experts who have sought to define the principles of viral neutralization by human antibodies. They explore and anticipate the obstacles and opportunities that will be encountered as the power of human antibodies is harnessed to address the vast, un-met need for effective anti-viral therapeutics.

Immunoglobulins. --- Immunoglobulins --- Virus diseases --- Therapeutic use. --- Treatment. --- Chemotherapy. --- Antiviral agents --- Viral diseases --- Viral infections --- Virus infections --- Communicable diseases --- Medical virology --- Pathogenic viruses --- Antibodies --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Medical virology. --- Virology. --- Medical microbiology --- Virology --- Microbiology

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Immunologists today are interested in all of the diverse cell-types involved in host defense and have a deeper appreciation of the importance of innate immune mechanisms as a first line of protection against pathogens. This volume thus discusses the isolation and functional characterization of cells involved in innate immunity in mouse and man, including mast cells and eosinophils. Other focuses include natural killer cells, methods in statistics, in vivo imaging, genome engineering, and mutagenesis and culture that are adapted to the study of innate immunity in these hosts. These are complemented with a series of chapters dealing with alternative models: plants, worms, mosquitoes, flies, and fish. Together, these approaches and models are being used to dissect the complex interplay between hosts and pathogens and contribute to developing strategies to help fight infection. With chapters written by experts on the cutting-edge of this technology, Innate Immunity is an essential reference for immunologists, histologists, geneticists, and molecular biologists.

Natural immunity --- Immunology, Comparative --- Killer Cells, Natural --- Laboratory Manuals --- Genetic Techniques --- Immunologic Techniques --- Cytological Techniques --- Immunity, Innate --- Lymphocytes --- Publication Formats --- Clinical Laboratory Techniques --- Immunity --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Immune System Phenomena --- Leukocytes, Mononuclear --- Publication Characteristics --- Leukocytes --- Phenomena and Processes --- Blood Cells --- Immune System --- Cells --- Hemic and Immune Systems --- Blood --- Anatomy --- Microbiology & Immunology --- Biology --- Health & Biological Sciences --- Natural immunity. --- Immunology, Comparative. --- Immunité naturelle --- Immunologie comparée --- EPUB-LIV-FT LIVBIOMO LIVMEDEC SPRINGER-B --- White Blood Corpuscles --- Blood Cells, White --- Blood Corpuscles, White --- White Blood Cells --- Blood Cell, White --- Blood Corpuscle, White --- Corpuscle, White Blood --- Corpuscles, White Blood --- Leukocyte --- White Blood Cell --- White Blood Corpuscle --- Mononuclear Leukocytes --- Leukocyte, Mononuclear --- Mononuclear Leukocyte --- Immune System Concepts --- Immune System Phenomenon --- Immune System Process --- Immune System Processes --- Concept, Immune System --- Concepts, Immune System --- Immune System Concept --- Phenomena, Immune System --- Phenomenon, Immune System --- Process, Immune System --- Processes, Immune System --- Anatomies --- Water --- Hemic System --- System, Hemic --- Cell --- Immune Systems --- System, Immune --- Systems, Immune --- Blood Corpuscles --- Blood Cell --- Blood Corpuscle --- Cell, Blood --- Cells, Blood --- Corpuscle, Blood --- Corpuscles, Blood --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Disease --- Diagnoses and Laboratory Examinations --- Diagnosis, Laboratory --- Laboratory Diagnosis --- Laboratory Examinations and Diagnoses --- Laboratory Techniques, Clinical --- Clinical Laboratory Technique --- Diagnoses, Laboratory --- Laboratory Diagnoses --- Laboratory Technique, Clinical --- Technique, Clinical Laboratory --- Techniques, Clinical Laboratory --- Lymphoid Cells --- Cell, Lymphoid --- Cells, Lymphoid --- Lymphocyte --- Lymphoid Cell --- Innate Immune Response --- Innate Immunity --- Immunity, Native --- Immunity, Natural --- Immunity, Non-Specific --- Resistance, Natural --- Immune Response, Innate --- Immune Responses, Innate --- Immunity, Non Specific --- Innate Immune Responses --- Native Immunity --- Natural Immunity --- Natural Resistance --- Non-Specific Immunity --- Cytologic Technics --- Cytological Technic --- Cytological Technics --- Cytological Technique --- Technic, Cytological --- Technics, Cytological --- Technique, Cytological --- Techniques, Cytological --- Cytologic Technic --- Technic, Cytologic --- Technics, Cytologic --- Cell Biology --- Antibody Dissociation --- Immunologic Technic --- Immunologic Technics --- Immunologic Technique --- Immunological Technics --- Immunological Techniques --- Technic, Immunologic --- Technics, Immunologic --- Technique, Immunologic --- Techniques, Immunologic --- Antibody Dissociations --- Dissociation, Antibody --- Dissociations, Antibody --- Immunological Technic --- Immunological Technique --- Technic, Immunological --- Technics, Immunological --- Technique, Immunological --- Techniques, Immunological --- Allergy and Immunology --- Genetic Technic --- Genetic Technics --- Genetic Technique --- Technic, Genetic --- Technics, Genetic --- Technique, Genetic --- Techniques, Genetic --- Genetics --- NK Cells --- Natural Killer Cells --- Cell, NK --- Cell, Natural Killer --- Cells, NK --- Cells, Natural Killer --- Killer Cell, Natural --- NK Cell --- Natural Killer Cell --- Comparative immunology --- Disease resistance --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- blood --- cytology --- immunology --- methods --- Immunology. --- Cytology. --- Human genetics. --- Medicine. --- Cell Biology. --- Human Genetics. --- Molecular Medicine. --- Cell biology --- Cellular biology --- Cytologists --- Immunobiology --- Life sciences --- Serology --- Heredity, Human --- Human biology --- Physical anthropology --- Health Workforce

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Mucosal Immunology is the official publication of the Society of Mucosal Immunology (SMI). It aims to provide a forum for both basic and clinical scientists to discuss all aspects of immunity and inflammation involving mucosal tissues. The journal reflects the interests of scientists studying gastrointestinal, pulmonary, nasopharyngeal, oral, ocular, and genitourinary immunology through the publication of original research articles, scholarly reviews, and timely commentaries, editorials and letters. Publication of basic, translational, and clinical studies will all be given equal consideration. In addition, Mucosal Immunology aims to provide a primary method of communication for the SMI governing board and its members through the publication of society news, announcements of planned meetings and conferences, discussions of policy concerns, and advertisements for job and training opportunities.

Immunology. Immunopathology --- Mucous membrane --- Mucous Membrane --- Immunity, Mucosal --- Muqueuses --- Mensuels. --- Immunologie. --- Recherche médicale. --- Immunology --- immunology. --- physiology. --- Immunologie --- Infections --- Immunology. --- Agriculture Sciences --- Soil Chemistry, Microbiology, Fertility & Fertilizers --- Mucosa --- Mucosal tissue --- Tunica mucosa --- immunology --- physiology --- Immune Response, Mucosal --- Mucosal Immunity --- Immune Responses, Mucosal --- Mucosal Immune Response --- Mucosal Immune Responses --- Mucous Membranes --- Lamina Propria --- Mucosal Tissue --- Muscularis Mucosae --- Membrane, Mucous --- Membranes, Mucous --- Mucosae, Muscularis --- Mucosal Tissues --- Propria, Lamina --- Tissue, Mucosal --- Tissues, Mucosal --- Administration, Mucosal --- Epithelium --- Membranes (Biology) --- Immunity, Mucosal. --- Medicine --- Antibodies --- Allergy --- Gastroenterology --- Biomedicine, general --- Allergology --- Internal medicine --- Digestive organs --- Allergic diseases --- Allergies --- Hypersensitivity --- Hypersensitivity, Immediate --- Immediate allergy --- Immediate hypersensitivity --- Immunologic diseases --- Immunoglobulin E --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Immunobiology --- Life sciences --- Serology --- Health Workforce --- Diseases --- MDPHYSIO MDALLERG