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During most of the 20th century, neurodegenerative diseases remained among the most enigmatic disorders of medicine. The scientific study of these conditions was descriptive in nature, detailing the clinical and neuropathological phenotypes associated with various diseases, but etiologies and pathogenic mechanisms remained obscure. Beginning in the 1970s, advances in two principal areas – biochemical pathology and molecular genetics – combined to yield powerful clues to the molecular underpinnings of several previously "idiopathic" brain disorders. Among the classical neurodegenerative diseases, perhaps the most rapid progress occurred in research on Alzheimer’s disease (AD). In disorders like Huntington’s disease, amyotrophic lateral sclerosis and even Parkinson’s disease, unbiased genetic screens, linkage analysis and positional cloning have identified causative genes that subsequently allowed the formulation of specific biochemical hypotheses. In sharp contrast, modern research on AD developed in the opposite order: the identification of the protein subunits of the classical brain lesions guided geneticists to disease-inducing genes, for example, APP, apolipoprotein E and tau. Thus, a biochemical hypothesis of disease - that AD is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies.
Alzheimer's disease --- Neuroplasticity. --- Pathophysiology. --- Research. --- Nervous system plasticity --- Neural adaptation --- Neural plasticity --- Neuronal adaptation --- Neuronal plasticity --- Plasticity, Nervous system --- Soft-wired nervous system --- Synaptic plasticity --- Adaptation (Physiology) --- Neurophysiology --- Developmental neurobiology --- Alzheimer disease --- Alzheimer's dementia --- Basal ganglia --- Presenile dementia --- Senile dementia --- Diseases --- Neurosciences. --- Human physiology. --- Human Physiology. --- Human biology --- Medical sciences --- Physiology --- Human body --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system
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Neuroscientist and expert on brain function and behavior Dr. Gary Small explores how technology's march forward has altered the way young minds develop, function, and interpret information. iBrain reveals a new evolution catalyzed by technological advancement and its future implications: Where do you fit in on the evolutionary chain? What are the professional, social, and political impacts of this new brain evolution? How must you adapt and at what price? While high-tech immersion can accelerate learning and boost creativity, it also has its glitches, among them the meteoric rise in ADD diagnoses, increased social isolation, and Internet addiction. To compete and thrive in the age of brain evolution, and to avoid these potential drawbacks, we must adapt, and iBrain--with its Technology Toolkit--equips us with tools and strategies needed to close the brain gap.--From publisher description.
Brain --- Digital media --- Neuroplasticity. --- Cerveau --- Médias numériques --- Plasticité neuronale --- Evolution. --- Psychological aspects. --- Evolution --- Aspect psychologique --- Neuroplasticity --- Evolution (Biology) --- Technology --- Behavior --- Biological Evolution --- Internet --- Neuronal Plasticity --- Mass media --- Digital communications --- Online journalism --- Electronic media --- New media (Digital media) --- Cyber Space --- Cyberspace --- World Wide Web --- Web, World Wide --- Wide Web, World --- Sociobiology --- Evolution, Biological --- Biology --- Biological fitness --- Homoplasy --- Natural selection --- Phylogeny --- Animal evolution --- Animals --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Science --- Industrial arts --- Material culture --- Applied science --- Arts, Useful --- Science, Applied --- Useful arts --- Adaptation (Physiology) --- Neurophysiology --- Developmental neurobiology --- Nervous system plasticity --- Neural adaptation --- Neural plasticity --- Neuronal adaptation --- Neuronal plasticity --- Plasticity, Nervous system --- Soft-wired nervous system --- Synaptic plasticity --- Cloud Computing --- Arts, Industrial --- Industrial Arts --- Cell Plasticity --- Axon Pruning --- Axonal Pruning --- Dendrite Arborization --- Dendrite Pruning --- Dendritic Arborization --- Dendritic Pruning --- Dendritic Remodeling --- Neural Plasticity --- Neurite Pruning --- Neuronal Arborization --- Neuronal Network Remodeling --- Neuronal Pruning --- Neuronal Remodeling --- Synaptic Plasticity --- Synaptic Pruning --- Brain Plasticity --- Plasticity, Neuronal --- Arborization, Dendrite --- Arborization, Dendritic --- Arborization, Neuronal --- Arborizations, Dendrite --- Arborizations, Dendritic --- Arborizations, Neuronal --- Axon Prunings --- Axonal Prunings --- Brain Plasticities --- Dendrite Arborizations --- Dendrite Prunings --- Dendritic Arborizations --- Dendritic Prunings --- Dendritic Remodelings --- Network Remodeling, Neuronal --- Network Remodelings, Neuronal --- Neural Plasticities --- Neurite Prunings --- Neuronal Arborizations --- Neuronal Network Remodelings --- Neuronal Plasticities --- Neuronal Prunings --- Neuronal Remodelings --- Neuroplasticities --- Plasticities, Brain --- Plasticities, Neural --- Plasticities, Neuronal --- Plasticities, Synaptic --- Plasticity, Brain --- Plasticity, Neural --- Plasticity, Synaptic --- Pruning, Axon --- Pruning, Axonal --- Pruning, Dendrite --- Pruning, Dendritic --- Pruning, Neurite --- Pruning, Neuronal --- Pruning, Synaptic --- Prunings, Axon --- Prunings, Axonal --- Prunings, Dendrite --- Prunings, Dendritic --- Prunings, Neurite --- Prunings, Neuronal --- Prunings, Synaptic --- Remodeling, Dendritic --- Remodeling, Neuronal --- Remodeling, Neuronal Network --- Remodelings, Dendritic --- Remodelings, Neuronal --- Remodelings, Neuronal Network --- Synaptic Plasticities --- Synaptic Prunings --- Psychological aspects --- physiology
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