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This publication presents the conclusions of an IPCS Workshop on Skin Sensitization in Chemical Risk Assessment. The workshop focused on the question of methods for dose-response assessment, to evaluate the relative ability of a chemical to induce sensitization in the skin, and hence inform risk assessment for humans. In addition this publication includes a series of short articles on this topic by leading experts in the field. The conclusions of the workshop cover such aspects as the nature and utility for risk assessment of the data produced by non-animal test methods (such as quantitative structure-activity relationships), in vitro testing approaches, animal test methods, and epidemiological studies. While traditional animal test methods used for identification and regulation of skin sensitizers have focused on determining whether or not a substance is a sensitizer, this report describes the use of tests for deriving more informative potency information.--Publisher's description.
Hazardous substances --- Risk assessment --- Environmental exposure --- Chemicals --- Health risk assessment --- Skin tests --- Toxicology --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Cutaneous tests --- Provocation tests (Medicine) --- Assessment, Health risk --- Health hazard appraisal --- Health hazard assessment --- Health risk appraisal --- HRA (Public health) --- Human risk assessment --- Medicine, Preventive --- Public health --- Environmental health --- Physiological effect
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This Harmonization Project Document presents the conclusions of an IPCS Workshop on Skin Sensitization in Chemical Risk Assessment. The workshop focused on the question of methods for dose-response assessment, to evaluate the relative ability of a chemical to induce sensitization in the skin, and hence inform risk assessment for humans. In addition this publication includes a series of short articles on this topic by leading experts in the field. The conclusions of the workshop cover such aspects as the nature and utility for risk assessment of the data produced by non-animal test methods (suc
Chemicals -- Physiological effect. --- Chemicals -- Risk assessment. --- Health risk assessment. --- Skin tests. --- Toxicology. --- Chemicals --- Hazardous substances --- Skin tests --- Toxicology --- Health risk assessment --- Skin Tests --- Hazardous Substances --- Risk Assessment --- Dermatitis, Contact --- Methods --- Dermatitis --- Immunologic Tests --- Environmental Pollutants --- Skin Diseases, Eczematous --- Investigative Techniques --- Risk --- Diagnostic Techniques and Procedures --- Risk Management --- Epidemiologic Measurements --- Immunologic Techniques --- Probability --- Skin Diseases --- Laboratory Techniques and Procedures --- Organization and Administration --- Public Health --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Diagnosis --- Toxic Actions --- Environment and Public Health --- Statistics as Topic --- Skin and Connective Tissue Diseases --- Chemical Actions and Uses --- Health Services Administration --- Health Care --- Health Care Evaluation Mechanisms --- Diseases --- Chemicals and Drugs --- Epidemiologic Methods --- Quality of Health Care --- Health Care Quality, Access, and Evaluation --- Environmental Engineering --- Civil & Environmental Engineering --- Engineering & Applied Sciences --- Physiological effect --- Risk assessment --- Physiological effect. --- Risk assessment. --- Electronic texts --- Biological and medical sciences. --- Assessment, Health risk --- Health hazard appraisal --- Health hazard assessment --- Health risk appraisal --- HRA (Public health) --- Human risk assessment --- Cutaneous tests --- Chemical compounds --- Compounds, Chemical --- Medicine, Preventive --- Public health --- Environmental health --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Provocation tests (Medicine) --- Chemistry
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