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Diabetes Mellitus --- Glucose Metabolism Disorders --- Endocrine System Diseases --- Diseases --- Metabolic Diseases --- Nutritional and Metabolic Diseases --- Diabetes Mellitus, Type 2 --- Medicine --- Health & Biological Sciences --- Clinical Endocrinology --- Diabetes Mellitus. --- Glucose Metabolism Disorders. --- Endocrine System Diseases. --- Disease. --- Metabolic Diseases. --- Nutritional and Metabolic Diseases. --- Diabetes Mellitus, Type 2.

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Diabetes --- Obesity --- Metabolic syndrome --- Diabetes Mellitus. --- Metabolic Diseases. --- Obesity. --- Clinical Endocrinology

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Research into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists investigating the metabolism of organophosphate insecticides and nerve gases and a few “mad” scientists searching for “natural” substrates. Since this time two new members PON2 and PON3 have been discovered, all 3 PONs have been shown to act as antioxidants and the PON family has taken centre stage as major players in the development of a wide variety of diseases such as cardiovascular disease, diabetes mellitus, rheumatism, Alzheimer and many more while remaining important in determining organophosphate toxicity. In September 2006 the 2nd International Conference on Paraoxonases took place in Hajdúszoboszló, Hungary, bringing together the world's foremost experts in the field. The current book is a distillation of the plenary lectures which took place at the meeting, resulting in a comprehensive up to date, state of the art review of current paraoxonase research.

Paraoxonase --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Aromatic esterase --- Arylesterase --- Esterases --- Composition --- Internal medicine. --- Cardiology. --- Diabetes. --- Metabolic diseases. --- Internal Medicine. --- Metabolic Diseases. --- Medical Biochemistry. --- Disorders of metabolism --- Metabolic diseases --- Metabolic disorders --- Metabolism, Disorders of --- Diseases --- Brittle diabetes --- Diabetes mellitus --- IDDM (Disease) --- Insulin-dependent diabetes --- Ketosis prone diabetes --- Type 1 diabetes --- Carbohydrate intolerance --- Endocrine glands --- Diabetic acidosis --- Glycosylated hemoglobin --- Heart --- Internal medicine --- Medicine, Internal --- Medicine --- Medical biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology

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Cet ouvrage traite de l'ensemble des manifestations cutanées et muqueuses observées au cours des différentes maladies infectieuses, métaboliques et toxiques. La première partie aborde de façon exhaustive les manifestations dermatologiques des maladies infectieuses rencontrées dans nos régions, sous les tropiques mais également les pathologies infectieuses émergentes et potentiellement impliquées dans les actes de bioterrorisme. La deuxième partie traite des signes cutanés et muqueux des maladies métaboliques héréditaires et acquises, infantiles et de l'adulte. La troisième partie est consacrée

Dermatology --- Communicable Diseases --- Metabolic Diseases --- Poisoning --- Communicable diseases --- Metabolism --- Dermatologie --- Maladies infectieuses --- Métabolisme, Troubles du --- Empoisonnement --- Disorders --- Dermatology. --- Communicable diseases. --- Métabolisme, Troubles du --- EPUB-LIV-FT LIVMEDEC SPRINGER-B --- Communicable Diseases. --- Metabolic Diseases. --- Poisoning. --- Contagion and contagious diseases --- Contagious diseases --- Infectious diseases --- Microbial diseases in human beings --- Zymotic diseases --- Diseases --- Infection --- Epidemics --- Medicine --- Skin

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Designed to be a practical handbook on clinical trial management in these key therapeutic areas, 'Clinical Trials in Rheumatoid Arthritis and Osteoarthritis' is aimed at principal investigators pharmaceutical physicians and other pharmaceutical staff involved in the design, conduct and monitoring of these increasingly complex diseases. In the last several years a new classes of biologic agents have emerged and changed the treatment paradigm for patients, not only with classically defined rheumatoid arthritis, but also with other related diseases such as ankylosing spondylitis and psoriatic arthritis. Furthermore, osteoarthritis is a major disease state that is often treated by the rheumatologist, but is one where patient management programs are currently limited with a need for new therapeutic approaches. In both inflammatory and non-inflammatory arthritic conditions, clinical trials have become both large and complex due to the nature of the diseases, with ever-challenging new surrogate end-points being employed. Topics covered in this title will therefore include study design, clinical endpoints, technical issues, data collection, use of centralized medical image reading facilities and biochemical marker laboratories, as well as data analysis and future therapies. This book takes the user through the process step-by-step from start to finish, also providing a background on the regulatory guidelines, ethical implications, endpoints, and current therapies.

Rheumatoid arthritis --- Osteoarthritis --- Clinical trials. --- Treatment. --- Controlled clinical trials --- Patient trials of new treatments --- Randomized clinical trials --- Trials, Clinical --- Clinical medicine --- Human experimentation in medicine --- Degenerative arthritis --- Degenerative joint disease --- Joint disease, Degenerative --- OA (Disease) --- Old age arthritis --- Osteoarthrosis --- Wear and tear arthritis --- Arthritis --- Adjuvant arthritis --- Arthritis deformans --- Arthrosis deformans --- Rheumatic gout --- Autoimmune diseases --- Blood hyperviscosity syndrome --- Rheumatism --- Research --- Rheumatology. --- Toxicology. --- Metabolic diseases. --- Orthopedics. --- Pharmacology/Toxicology. --- Metabolic Diseases. --- Orthopaedics --- Orthopedia --- Surgery --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Disorders of metabolism --- Metabolic diseases --- Metabolic disorders --- Metabolism, Disorders of --- Diseases --- Internal medicine --- Connective tissues --- Joints --- Toxicology --- Pharmacology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect