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This dissertation by Linda Engström investigates gene expression in the brain and adrenal gland during systemic immune challenges. It examines the role of endotoxins and cytokines in activating the autonomic nervous system and their effects on homeostasis. The research focuses on the expression of enkephalin and prostaglandin E2 within rat models, exploring their influence on stress hormone release and immune responses. The study reveals mechanisms of neuronal and humoral pathways in the hypothalamic-pituitary-adrenal (HPA) axis, highlighting the complex interactions between the nervous and immune systems. Aimed at researchers and students in medical and health sciences, it provides insights into neuroimmune communication.
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