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Bone and Osteoarthritis places emphasis on the molecular and cellular events that lead to osteoarthritis, stressing the role of subchondral bone, which distinguishes this from other books on the disease. A novel aspect is the attention given to the possible epigenetic basis, together with a discussion of the genetics predisposing to osteoarthritis. Detailed analyses are given of the role of the synovium, of the molecular mechanisms that lead to degradation of the cartilage matrix, of the hypertrophy of the cartilage cell, of the anabolic and catabolic roles of cytokines, may lead to novel approaches to clinical treatment, utilizing anabolic mediators or molecules that target steps in the disease process. Also discussed are animal models and how mechano-responsiveness is compromised by mechanical injury. Orthopedics and rheumatology have become close conceptually, as advances in bone and joint biology have enabled bench and translational scientists, as well as practitioners, to approach clinical problems comprehensively. Because bone plays a role in initiating osteoarthritis, therapeutic approaches focusing on bone tissue are included in the discussion of novel treatments. The general topic of osteoarthritis is therefore a timely subject for a series on bone biology. This book, intended for clinicians, researchers and students, provides information that will orient the novice and update the specialist. No other book treats the relationship of bone to osteoarthritis in similar fashion or provides a comparable underpinning of joint pathophysiology.

Osteoarthritis --- Bone. --- Pathogenesis. --- Bones --- Calcification --- Connective tissues --- Skeleton --- Degenerative arthritis --- Degenerative joint disease --- Joint disease, Degenerative --- OA (Disease) --- Old age arthritis --- Osteoarthrosis --- Wear and tear arthritis --- Arthritis

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This new companion to Hochberg et al.'s Rheumatology masterwork presents current insights into the causes, detection, and therapy of this condition. It provides ""one-stop"" coverage of scientific and clinical developments, including new concepts in epidemiology and genetics and pathogenic mechanisms · new developments in diagnostic interventions and prevention · and the very latest concepts in treatment.Features the work of leading experts in osteoarthritis. Presents current diagnostic criteria and knowledge of pathogenic mechanisms.Discusses the very latest advances

Osteoarthritis. --- Rheumatology. --- Internal medicine --- Connective tissues --- Joints --- Degenerative arthritis --- Degenerative joint disease --- Joint disease, Degenerative --- OA (Disease) --- Old age arthritis --- Osteoarthrosis --- Wear and tear arthritis --- Arthritis --- Diseases

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The 32nd Japanese Hip Society (JHS) Congress was held November 6–8, 2005, in Niigata, Japan. Guest speakers from many countries and specialists for hip disease presented papers that focused on joint preservation for osteoarthritis of the hip, joint preservation for aseptic necrosis of the femoral head, treatment for epiphyseolysis capitis femoris, and up-to-date information and knowledge on joint arthroplasty. Altogether, there were many important presentations about joint preservation and replacement. This book covers the main themes of the congress. The starting point for the treatment of hip disease depends on how we can preserve the natural hip joint and on steps leading to regeneration of the diseased, injured, or destroyed joint. Preservation and regeneration treatments following traditional and theoretical methods do not need to use expensive materials, such as the arti?cial joints used in arthroplasty. On the other hand, preservation and regeneration tre- ments are dif?cult to perform and require a lengthy rehabilitation period.

Hip joint --- Osteoarthritis --- Total hip replacement --- Diseases --- Treatment --- Coxa --- Joints --- Hip arthroplasty --- Hip replacement --- Total hip arthroplasty --- Total hip joint replacement --- Arthroplasty --- Artificial hip joints --- Degenerative arthritis --- Degenerative joint disease --- Joint disease, Degenerative --- OA (Disease) --- Old age arthritis --- Osteoarthrosis --- Wear and tear arthritis --- Arthritis --- Surgery --- Orthopedic surgery. --- Surgical Orthopedics. --- Operative orthopedics --- Orthopedics --- Surgery, Operative --- Orthopedics. --- Orthopaedics --- Orthopedia

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S. E. BAILEY Department of Human Evolution Max Planck Institute for Evolutionary Anthropology Deutscher Platz 6 D-04103 Leipzig, Germany and Center for the Study of Human Origins, Department of Anthropology, New York University, 25 Waverly Place New York, NY 10003, USA sbailey@nyu. edu J. -J. HUBLIN Department of Human Evolution Max Planck Institute for Evolutionary Anthropology Deutscher Platz 6 D-04103 Leipzig, Germany hublin@eva. mpg. de When faced with choosing a topic to as teeth represent, by far, the most abundant be the focus of the first symposium material documenting different species of in Human Evolution at the Max Planck extinct non-human primates and hominins. As Institute for Evolutionary Anthropology in such, much of what we know about non- Leipzig, a paleoanthropological perspective human primate and hominin evolution is based of dental anthropology was a natural choice. on teeth. Teeth make up a disproportionate number Teeth have been a focus of interest for of the fossils discovered. They represent physical anthropologists over many gen- strongly mineralized organs of compact shape, ations. Teeth provide a multitude of which allow better preservation in geological information about humans – including deposits and archaeological sites than any cultural treatment, pathology, morphological other part of the skeleton. As a result, variation, and development. The presence of since the discoveries of the first fossils of culturally induced wear (toothpick grooves, extinct species, vertebrate paleontology has for example) reveals something about what been built primarily on analyses of teeth.

beeldverwerking --- Computer. Automation --- Ethnology. Cultural anthropology --- stomatologie --- Human anatomy --- vormgeving --- Artificial intelligence. Robotics. Simulation. Graphics --- simulaties --- Stomatology --- anatomie --- Teeth --- Human evolution. --- Teeth, Fossil. --- Paleoanthropology. --- Evolution (Biology). --- Dental anthropology. --- Animals. --- Humans. --- Fossils. --- Paleodontology. --- Paleodontology --- Tooth --- Tooth Wear. --- Anatomy, Comparative. --- Evolution. --- Primates. --- Hominidae. --- Biological Evolution. --- SOCIAL SCIENCE --- Methods. --- Anatomy & histology. --- Anthropology --- Physical. --- Anthropology. --- Life sciences. --- Paleontology . --- Human anatomy. --- Life Sciences, general. --- Evolutionary Biology. --- Paleontology. --- Anatomy. --- Evolutionary biology. --- Anatomy, Human --- Anatomy --- Human biology --- Medical sciences --- Human body --- Fossilogy --- Fossilology --- Palaeontology --- Paleontology, Zoological --- Paleozoology --- Historical geology --- Zoology --- Fossils --- Prehistoric animals in motion pictures --- Biosciences --- Sciences, Life --- Science --- Human beings --- Animal evolution --- Animals --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Biology --- Evolution --- Biological fitness --- Homoplasy --- Natural selection --- Phylogeny --- Primitive societies --- Social sciences --- Dental anthropology --- Evolution (Biology) --- Human evolution --- Paleoanthropology --- Teeth, Fossil