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Cellular signal transduction --- Genetic regulation --- Control theory --- Gene Expression Regulation --- Genomics --- Models, Theoretical --- Signal Transduction

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Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volumes 1 & 2, present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer and neurodegenerative diseases. These comprehensive volumes integrate the most innovative and current findings from several related disciplines of scientific research, including pathology, genetics, virology, cell biology, immunology, and molecular biology. Volume 1 is divided into two sections: "Malignant Transformation and Metastasis" and "Molecular Basis of Disease Therapy." Volume 2 follows a similar structure and is divided into sections entitled "Kinases and Phosphate" and "Molecular Basis of Cell Death." All of the contributors are at the forefront of scientific discovery, and the reviews they present systemically examine the most exciting and innovative aspects of their particular areas of expertise. Researchers will find these volumes of major benefit as they search for novel and more effective treatments for human diseases.

Apoptosis. --- Pathology, Molecular. --- Cellular signal transduction. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Molecular pathology --- Molecular biology --- Physiology, Pathological --- Cell death

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A thorough understanding of cellular and molecular mechanisms involved in the individual expression of toxic effects provides an important tool for assessment of human health risk. New aspects, major advances, and new areas in molecular and cellular biology and toxicology demand updated sources of information to elucidate the functional mechanics of human toxicology. Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets, Second Edition retains the accessible format of the original to present the general principles that link xenobiotic-induced toxicity with the molecular pathways that underlie these toxic effects. Extensively illustrated, this book forms a conceptual bridge between multiple events at the molecular level and the determinants of toxicity at the physiological and cellular level. Specific examples of drugs, environmental pollutants, and other chemicals are carefully chosen to illustrate and highlight the fundamental mechanisms of toxicity at different toxicokinetic and toxicodynamic levels. The book includes references and review articles at the end of each chapter, as well as boxed text for relevant review information on biological, biochemical, molecular, and toxicological background. Linking molecular pathways to more general biomedical contexts, the author ensures that the reader is not lost in the details and instead receives a broad understanding of the processes underlying xenobiotic toxicity. New in the Second Edition - Updated chapters - Types of toxic responses - Disruption of signal transduction by xenobiotics - Disruption of mitochondrial function-Novel mechanisms derived from systems toxicology

moleculaire biologie --- farmacologie --- Pharmacology. Therapy --- Toxicology --- toxicologie --- Molecular toxicology --- Toxicity tests --- Dose-response relationship, drug --- Xenobiotics --- Oxidative stress --- Cell physiology --- toxicity --- drug effects --- Signal Transduction --- Molecular Biology

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The book summarizes our progress in understanding the receptor and intracellular signaling mechanisms utilized by a family of proteins called the semaphorins. Originally these protein were identified as ""axon guidance cues"" important for the formation of nerve tracts but now it is realized that semaphorins subserve several distinct functions in a multitude of organ systems. The purpose of this book is to summarize our knowledge and make it available as a useful and comprehensive tool for the scientific community. This book will both be interesting for people working in the field as well as c

Semaphorins. --- Cell receptors. --- Cellular signal transduction. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- Semaphorin --- Carrier proteins --- Neurosciences. --- Oncology. --- Immunology. --- Cancer Research. --- Immunobiology --- Life sciences --- Serology --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Tumors --- Cancer research. --- Cancer research

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Sports ophthalmology --- Sensation --- Ocular Physiological Processes --- Light Signal Transduction --- Medicine --- Nervous System Physiological Processes --- Signal Transduction --- Psychophysiology --- Health Occupations --- Ocular Physiological Phenomena --- Psychological Phenomena and Processes --- Nervous System Physiological Phenomena --- Cell Physiological Processes --- Biochemical Processes --- Disciplines and Occupations --- Phenomena and Processes --- Biochemical Phenomena --- Psychiatry and Psychology --- Cell Physiological Phenomena --- Chemical Processes --- Musculoskeletal and Neural Physiological Phenomena --- Chemical Phenomena --- Vision, Ocular --- Sports Medicine --- Health & Biological Sciences --- Ophthalmology & Optometry --- Medicine, Sport --- Medicine, Sports --- Sport Medicine --- Psychology, Sports --- Physical Conditioning, Human --- Light Signal Transduction, Visual --- Ocular Vision --- Visual Light Signal Transduction --- Visual Phototransduction --- Visual Transduction --- Vision --- Phototransduction, Visual --- Transduction, Visual --- Eye --- Ophthalmology --- Visual Perception --- Chemical Phenomenon --- Chemical Process --- Physical Chemistry Phenomena --- Physical Chemistry Process --- Physicochemical Phenomenon --- Physicochemical Process --- Chemical Concepts --- Physical Chemistry Concepts --- Physical Chemistry Processes --- Physicochemical Concepts --- Physicochemical Phenomena --- Physicochemical Processes --- Chemical Concept --- Chemistry Process, Physical --- Chemistry Processes, Physical --- Concept, Chemical --- Concept, Physical Chemistry --- Concept, Physicochemical --- Concepts, Chemical --- Concepts, Physical Chemistry --- Concepts, Physicochemical --- Phenomena, Chemical --- Phenomena, Physical Chemistry --- Phenomena, Physicochemical --- Phenomenon, Chemical --- Phenomenon, Physicochemical --- Physical Chemistry Concept --- Physicochemical Concept --- Process, Chemical --- Process, Physical Chemistry --- Process, Physicochemical --- Processes, Chemical --- Processes, Physical Chemistry --- Processes, Physicochemical --- Musculoskeletal and Neural Physiological Concepts --- Musculoskeletal and Neural Physiological Phenomenon --- Musculoskeletal and Neural Physiology --- Cell Physiological Phenomenon --- Cell Physiological Process --- Physiology, Cell --- Cell Physiology --- Phenomena, Cell Physiological --- Phenomenon, Cell Physiological --- Physiological Process, Cell --- Physiological Processes, Cell --- Process, Cell Physiological --- Processes, Cell Physiological --- Cells --- Biochemical Concepts --- Biochemical Phenomenon --- Biochemical Process --- Phenomena, Biochemical --- Biochemical Concept --- Concept, Biochemical --- Concepts, Biochemical --- Phenomenon, Biochemical --- Process, Biochemical --- Processes, Biochemical --- Molecular Biology --- Nervous System Physiological Concepts --- Nervous System Physiological Phenomenon --- Nervous System Physiological Process --- Physiology, Nervous System --- Nervous System Physiologic Processes --- Nervous System Physiology --- System Physiology, Nervous --- Nervous System --- Eye Physiology --- Ocular Physiologic Process --- Ocular Physiological Concepts --- Ocular Physiological Phenomenon --- Ocular Physiological Process --- Physiology of the Eye --- Physiology, Ocular --- Visual Physiology --- Ocular Physiologic Processes --- Ocular Physiology --- Concept, Ocular Physiological --- Concepts, Ocular Physiological --- Ocular Physiological Concept --- Phenomena, Ocular Physiological --- Phenomenon, Ocular Physiological --- Physiologic Process, Ocular --- Physiologic Processes, Ocular --- Physiological Concept, Ocular --- Physiological Concepts, Ocular --- Physiological Process, Ocular --- Physiological Processes, Ocular --- Physiology, Eye --- Physiology, Visual --- Process, Ocular Physiologic --- Process, Ocular Physiological --- Processes, Ocular Physiologic --- Processes, Ocular Physiological --- Health Professions --- Health Occupation --- Health Profession --- Profession, Health --- Professions, Health --- Occupations --- Mind-Body Relationship (Physiology) --- Physiologic Psychology --- Physiological Psychology --- Psychology, Physiologic --- Mind-Body Relations (Physiology) --- Psychology, Physiological --- Mind Body Relations (Physiology) --- Mind Body Relationship (Physiology) --- Mind-Body Relation (Physiology) --- Mind-Body Relationships (Physiology) --- Physiologic Psychologies --- Psychologies, Physiologic --- Relation, Mind-Body (Physiology) --- Relations, Mind-Body (Physiology) --- Relationship, Mind-Body (Physiology) --- Relationships, Mind-Body (Physiology) --- Psychosomatic Medicine --- Mind-Body Relations, Metaphysical --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Cell Signaling --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- Cell Communication --- Receptor-CD3 Complex, Antigen, T-Cell --- Receptor Cross-Talk --- Feedback, Physiological --- Gasotransmitters --- Medical Specialities --- Medical Specialties --- Medical Specialty --- Specialities, Medical --- Specialties, Medical --- Specialty, Medical --- Medical Speciality --- Speciality, Medical --- Health Workforce --- Phototransduction --- Signal Transduction, Light --- Transduction, Light Signal --- Photoreceptors, Plant --- Organoleptic --- Sensory Function --- Function, Sensory --- Functions, Sensory --- Sensations --- Sensory Functions --- Perception --- Sports medicine --- physiology