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2007 (5)

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Pancreas
Authors: ---
ISBN: 3805582404 9783805582407 3318014362 Year: 2007 Publisher: S. Karger

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Abstract

The mouse in biomedical research -
Authors: --- ---
ISBN: 012369454X 9780123694560 0123694566 9780123694577 0123694574 9780123694584 0123694582 0123694558 9780123694553 9780123694546 Year: 2007 Publisher: Amsterdam Boston : Academic Press Elsevier,

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Abstract

History, Wild Mice, and Genetics, the first volume in the four volume set, The Mouse in Biomedical Research, provides information about the history, biology and genomics of the laboratory mouse (Mus musculus), as well as basic information on maintenance and use of mouse stocks. Mouse origins and relationships are covered in chapters on history, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are covered in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome. Maintenance of laboratory mice is described in chapters on breeding systems for various types of strains and stocks and genetic monitoring. Use of the mouse as a model system for basic biomedical research is described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. The information in Volume 1 serves as a primer for scientists new to the field of mouse research.

Animal models in toxicology
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ISBN: 0824754077 9780824754075 Year: 2007 Publisher: Boca Raton : CRC Press,

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Abstract

Comparative physiology, natural animal models, and clinical medicine
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ISBN: 1281867551 9786611867553 1860949495 9781860949494 9781281867551 6611867554 9781860947827 1860947824 Year: 2007 Publisher: London Imperial College Press

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Abstract

This book describes a novel and unique approach to the treatment of human diseases based on the study of natural animal models. A natural animal model is defined as an animal group or species that possesses a set of biochemical/physiological characteristics which are natural and adaptive for that animal, but are quite abnormal for humans. For example, how is it that birds can tolerate blood glucose concentrations which in humans are associated with diabetes. The natural animal model is living proof that a biological answer to this question is available. By studying natural animal models, we ca


Book
Conditional Mutagenesis: An Approach to Disease Models
Authors: ---
ISSN: 01712004 ISBN: 1280803924 9786610803927 3540351094 Year: 2007 Volume: v. 178 Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer,

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Abstract

Leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse (part 1) and their application to model human physiology and pathophysiology (part 2). It illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. Finally the book considers the development of new drugs to treat them.

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