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Disease Models, Animal. --- Pancreas --- Pancreas --- Pancreas --- Pancreatic Diseases --- Diseases. --- Pathophysiology. --- physiopathology. --- physiopathology.
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History, Wild Mice, and Genetics, the first volume in the four volume set, The Mouse in Biomedical Research, provides information about the history, biology and genomics of the laboratory mouse (Mus musculus), as well as basic information on maintenance and use of mouse stocks. Mouse origins and relationships are covered in chapters on history, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are covered in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome. Maintenance of laboratory mice is described in chapters on breeding systems for various types of strains and stocks and genetic monitoring. Use of the mouse as a model system for basic biomedical research is described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. The information in Volume 1 serves as a primer for scientists new to the field of mouse research.
Mice as laboratory animals. --- Souris (Animaux de laboratoire) --- Mice as laboratory animals --- Models, animal --- Disease models, animal --- Animals, laboratory --- Mice --- immunology --- Rodent diseases --- diagnosis --- prevention and control --- epidemiology --- transmission
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Toxicology --- Toxicity testing --- Animals, Laboratory --- Models, Animal --- Toxicity Tests --- Animal models --- methods --- Ferret. --- Fishes. --- Animals, Laboratory. --- Dogs. --- Rabbits. --- Toxicology - Animal models --- Toxicology - methods --- Dogs --- Rabbits --- Annelida --- Primates --- Rodentia --- Species specificity --- Swine, miniature
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This book describes a novel and unique approach to the treatment of human diseases based on the study of natural animal models. A natural animal model is defined as an animal group or species that possesses a set of biochemical/physiological characteristics which are natural and adaptive for that animal, but are quite abnormal for humans. For example, how is it that birds can tolerate blood glucose concentrations which in humans are associated with diabetes. The natural animal model is living proof that a biological answer to this question is available. By studying natural animal models, we ca
Diseases --- Physiology, Comparative. --- Laboratory animals. --- Animals, Experimental --- Animals, Laboratory --- Animals in research --- Experimental animals --- Lab animals --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation --- Comparative physiology --- Medicine, Comparative --- Zoology --- Animal disease models --- Disease models, Animal --- Animal models in research --- Medicine, Experimental --- Pathology, Comparative --- Pathology, Experimental --- Animal models. --- Physiology, Comparative
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Leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse (part 1) and their application to model human physiology and pathophysiology (part 2). It illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. Finally the book considers the development of new drugs to treat them.
Mutagenesis. --- Diseases --- Mice --- Genomes. --- Animal models. --- Genetics. --- Genetics --- Genomics --- Haploidy --- House mice --- House mouse --- Mouse --- Mus musculus --- Rodents --- Animal disease models --- Disease models, Animal --- Animal models in research --- Medicine, Comparative --- Medicine, Experimental --- Pathology, Comparative --- Pathology, Experimental --- Mutation (Biology) --- Radiogenetics --- Teratogenesis --- Toxicology. --- Medicine. --- Human genetics. --- Biochemistry. --- Pharmacology/Toxicology. --- Molecular Medicine. --- Human Genetics. --- Medical Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Heredity, Human --- Human biology --- Physical anthropology --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Composition --- Toxicology --- Health Workforce --- Pharmacology. --- Molecular biology. --- Medical biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules --- Systems biology --- Drug effects --- Medical pharmacology --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect
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