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Dosage Forms. --- Biopharmaceutics. --- Drug Design. --- Drugs --- Médicaments --- Dosage forms. --- Design. --- Formes pharmaceutiques --- Conception --- Drug Modeling --- Design, Drug --- Designs, Drug --- Drug Designs --- Drug Modelings --- Modeling, Drug --- Modelings, Drug --- Chemistry, Pharmaceutical --- Dosage Form --- Form, Dosage --- Forms, Dosage --- Drug Administration Routes --- Drug Delivery Systems --- Médicaments --- Biopharmaceutics --- Dosage Forms --- Drug Design --- Pharmaceutics --- Pharmaceutic --- Compounding, Drug --- Dosage forms of drugs --- Drug compounding --- Pharmaceutical compounding --- Pharmaceutical dosage forms --- Drug delivery systems --- Drug design --- Pharmaceutical design --- Drug development --- Design --- Dosage forms

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Biological Availability. --- Solubility --- Dosage Forms. --- Drug Administration Routes. --- Drug Delivery Systems --- Lipids --- Drugs --- Solutions (Pharmacy) --- Lipides --- Médicaments --- Solutions (Pharmacie) --- drug effects. --- methods. --- Therapeutic use. --- Solubility. --- Dosage forms. --- Emploi en thérapeutique --- Solubilité --- Formes pharmaceutiques --- Bioavailability. --- Solutions. --- Solutions (Pharmacy). --- Administration. --- Drug effects. --- Methods.

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It is more evident now than ever before that dynamic organization of human genome into nucleoprotein structure, chromatin confers the unique regulatory mechanisms for most of the cellular phenomena, which include replication, transcription, DNA repair, recombination and also apoptosis. The dynamic nature of the chromatin is regulated by chromatin modifications (epigenetic alterations), remodeling, histone chaperones and functional interactions of different chromatin interacting n- histone proteins. Dysfunction of this highly inter connected machineries disturb the cellular homoeostasis, and thereby causes several diseases. As we advance in our knowledge of chromatin function and also disease mechanisms in more details, their causal relationship is becoming more evident. This has lead to the identification of chromatin function as target for new generation therapeutics. In the light of these advances, it happens to be the right time to explore current insights into various aspect of chromatin and disease connection under one cover. Authors who are actively involved in chromatin research and have made several original contributions to develop latest paradigms in the field have written the chapters of this book. Significantly, the authors’ repertoire is truly international. They come from eight different countries of Asia, Europe and America. The book has been divided into three different parts. Part I introduces the reader to the dynamic nature of chromatin structure and its link to diseases. First two chapters in this part deal with the chromatin architecture, chromatin dynamics in the cell cycle and molecular mechanism of chromatin remodeling.

Chromatin. --- Epigenesis. --- Drug targeting. --- Drugs --- Site-specific drug delivery --- Targeting of drugs --- Target organs (Anatomy) --- Embryology --- Evolution (Biology) --- Genetics --- Chromosomes --- Nucleoproteins --- Targeting --- Dosage forms --- Biochemistry. --- Microbiology. --- Medical virology. --- Biochemistry, general. --- Medical Microbiology. --- Virology. --- Medical microbiology --- Virology --- Virus diseases --- Microbial biology --- Biology --- Microorganisms --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Composition --- Medical microbiology. --- Microbiology

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Injections --- Musculoskeletal system --- Pain --- Investigative Techniques --- Neurologic Manifestations --- Diseases --- Signs and Symptoms --- Drug Administration Routes --- Sensation --- Psychophysiology --- Pathological Conditions, Signs and Symptoms --- Drug Therapy --- Nervous System Diseases --- Nervous System Physiological Processes --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Therapeutics --- Nervous System Physiological Phenomena --- Psychological Phenomena and Processes --- Musculoskeletal and Neural Physiological Phenomena --- Psychiatry and Psychology --- Phenomena and Processes --- Musculoskeletal Diseases --- Methods --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Treatment --- Methodological Studies --- Methodological Study --- Procedures --- Studies, Methodological --- Study, Methodological --- Method --- Procedure --- Orthopedic Disorders --- Musculoskeletal Disease --- Orthopedic Disorder --- Injectables --- Injectable --- Injection --- Ache --- Pain, Burning --- Pain, Crushing --- Pain, Migratory --- Pain, Radiating --- Pain, Splitting --- Suffering, Physical --- Aches --- Burning Pain --- Burning Pains --- Crushing Pain --- Crushing Pains --- Migratory Pain --- Migratory Pains --- Pains, Burning --- Pains, Crushing --- Pains, Migratory --- Pains, Radiating --- Pains, Splitting --- Physical Suffering --- Physical Sufferings --- Radiating Pain --- Radiating Pains --- Splitting Pain --- Splitting Pains --- Sufferings, Physical --- Analgesia --- Pain Insensitivity, Congenital --- Analgesics --- Hyperalgesia --- Palliative Care --- Musculoskeletal and Neural Physiological Concepts --- Musculoskeletal and Neural Physiological Phenomenon --- Musculoskeletal and Neural Physiology --- Nervous System Physiological Concepts --- Nervous System Physiological Phenomenon --- Nervous System Physiological Process --- Physiology, Nervous System --- Nervous System Physiologic Processes --- Nervous System Physiology --- System Physiology, Nervous --- Nervous System --- Therapy --- Therapeutic --- Therapies --- Treatments --- Disease --- Nervous System Disorders --- Neurological Disorders --- Neurologic Disorders --- Disease, Nervous System --- Diseases, Nervous System --- Disorder, Nervous System --- Disorder, Neurologic --- Disorder, Neurological --- Disorders, Nervous System --- Disorders, Neurologic --- Disorders, Neurological --- Nervous System Disease --- Nervous System Disorder --- Neurologic Disorder --- Neurological Disorder --- Neurology --- Therapy, Drug --- Chemotherapy --- Pharmacotherapy --- Chemotherapies --- Drug Therapies --- Pharmacotherapies --- Therapies, Drug --- Pharmaceutical Preparations --- Pharmacologic Actions --- Symptoms and General Pathology --- Mind-Body Relationship (Physiology) --- Physiologic Psychology --- Physiological Psychology --- Psychology, Physiologic --- Mind-Body Relations (Physiology) --- Psychology, Physiological --- Mind Body Relations (Physiology) --- Mind Body Relationship (Physiology) --- Mind-Body Relation (Physiology) --- Mind-Body Relationships (Physiology) --- Physiologic Psychologies --- Psychologies, Physiologic --- Relation, Mind-Body (Physiology) --- Relations, Mind-Body (Physiology) --- Relationship, Mind-Body (Physiology) --- Relationships, Mind-Body (Physiology) --- Psychosomatic Medicine --- Mind-Body Relations, Metaphysical --- Organoleptic --- Sensory Function --- Function, Sensory --- Functions, Sensory --- Sensations --- Sensory Functions --- Perception --- Administration Routes, Drug --- Administration Route, Drug --- Drug Administration Route --- Route, Drug Administration --- Routes, Drug Administration --- Dosage Forms --- Drug Delivery Systems --- Symptoms and Signs --- Focal Neurologic Deficits --- Manifestations, Neurologic --- Manifestations, Neurological --- Neurologic Dysfunction --- Neurologic Findings --- Neurologic Manifestation --- Neurologic Signs --- Neurologic Symptoms --- Neurological Manifestations --- Neurologic Deficits --- Neurologic Signs and Symptoms --- Deficit, Focal Neurologic --- Deficit, Neurologic --- Deficits, Focal Neurologic --- Deficits, Neurologic --- Dysfunction, Neurologic --- Dysfunctions, Neurologic --- Finding, Neurologic --- Findings, Neurologic --- Focal Neurologic Deficit --- Manifestation, Neurologic --- Manifestation, Neurological --- Neurologic Deficit --- Neurologic Deficit, Focal --- Neurologic Deficits, Focal --- Neurologic Dysfunctions --- Neurologic Finding --- Neurologic Sign --- Neurologic Symptom --- Neurological Manifestation --- Sign, Neurologic --- Signs, Neurologic --- Symptom, Neurologic --- Symptoms, Neurologic --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Emotions --- Pleasure --- Senses and sensation --- Symptoms --- Suffering --- Locomotor system --- Musculo-skeletal system --- Skeletomuscular system --- Jabs (Injections) --- Shots (Injections) --- Drugs --- physiology --- therapy --- drug therapy --- therapeutic use --- Administration --- Techniques --- Technique