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Molecular biology --- General microbiology --- Bacterial genetics --- Bacteriophages --- Bacteria --- Chromosomes, Bacterial --- Genetics, Microbial --- Molecular Biology --- Genetics --- genetics --- methods --- Bacterial genetics. --- Molecular genetics. --- Chromosomes, Bacterial. --- Genetics. --- genetics. --- methods. --- 577.2 --- Molecular bases of life. Molecular biology --- Methods. --- 577.2 Molecular bases of life. Molecular biology --- Molecular genetics --- Viral genetics --- Bacteriology --- Microbial genetics --- Bacteriophages - Genetics --- Bacteria - genetics --- Bacteriophages - genetics --- Genetics, Microbial - methods --- Molecular Biology - methods

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Cytogenetics is a very important research tool in basic and applied research. The uses of cytogenetics in human-population monitoring, in biological dosimetry in radiation accidents and in astronauts and as a predictive measure of cancer are topics discussed in this book. The book will help the reader to better understand cytogenetics and the intricacies of the methodology. The different methods of fluorescence in situ hybridization are discussed and the results achieved are presented. The book provides a comprehensive review of basic and applied aspects of cytogenetics and therefore will be of interest to all who are interested in chromosomes and their alterations by different types of mutagens, including chemical mutagens and ionizing and nonionizing radiation, with special reference to electromagnetic fields.

proteomics --- Genetics --- histologie --- Animal genetics. Animal evolution --- Histology. Cytology --- Oncology. Neoplasms --- proteïnen --- genetica --- oncologie --- cytologie --- Human chromosome abnormalities --- Medical genetics --- Chromosome Aberrations --- Chromosome Disorders --- Abnormalities, Autosome --- Abnormalities, Chromosomal --- Abnormalities, Chromosome --- Chromosomal Aberrations --- Chromosome Abnormalities --- Cytogenetic Abnormalities --- Autosome Abnormalities --- Cytogenetic Aberrations --- Aberration, Chromosomal --- Aberration, Chromosome --- Aberration, Cytogenetic --- Aberrations, Chromosomal --- Aberrations, Chromosome --- Aberrations, Cytogenetic --- Abnormalities, Cytogenetic --- Abnormality, Autosome --- Abnormality, Chromosomal --- Abnormality, Chromosome --- Abnormality, Cytogenetic --- Autosome Abnormality --- Chromosomal Aberration --- Chromosomal Abnormalities --- Chromosomal Abnormality --- Chromosome Aberration --- Chromosome Abnormality --- Cytogenetic Aberration --- Cytogenetic Abnormality --- Chromosomes --- Cytogenetics --- Genetics, Medical --- Cytogenetic Analysis --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Human chromosomes --- Chromosome abnormalities --- etiology --- abnormalities --- Genetic aspects --- Abnormalities

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It is more evident now than ever before that dynamic organization of human genome into nucleoprotein structure, chromatin confers the unique regulatory mechanisms for most of the cellular phenomena, which include replication, transcription, DNA repair, recombination and also apoptosis. The dynamic nature of the chromatin is regulated by chromatin modifications (epigenetic alterations), remodeling, histone chaperones and functional interactions of different chromatin interacting n- histone proteins. Dysfunction of this highly inter connected machineries disturb the cellular homoeostasis, and thereby causes several diseases. As we advance in our knowledge of chromatin function and also disease mechanisms in more details, their causal relationship is becoming more evident. This has lead to the identification of chromatin function as target for new generation therapeutics. In the light of these advances, it happens to be the right time to explore current insights into various aspect of chromatin and disease connection under one cover. Authors who are actively involved in chromatin research and have made several original contributions to develop latest paradigms in the field have written the chapters of this book. Significantly, the authors’ repertoire is truly international. They come from eight different countries of Asia, Europe and America. The book has been divided into three different parts. Part I introduces the reader to the dynamic nature of chromatin structure and its link to diseases. First two chapters in this part deal with the chromatin architecture, chromatin dynamics in the cell cycle and molecular mechanism of chromatin remodeling.

Chromatin. --- Epigenesis. --- Drug targeting. --- Drugs --- Site-specific drug delivery --- Targeting of drugs --- Target organs (Anatomy) --- Embryology --- Evolution (Biology) --- Genetics --- Chromosomes --- Nucleoproteins --- Targeting --- Dosage forms --- Biochemistry. --- Microbiology. --- Medical virology. --- Biochemistry, general. --- Medical Microbiology. --- Virology. --- Medical microbiology --- Virology --- Virus diseases --- Microbial biology --- Biology --- Microorganisms --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Composition --- Medical microbiology. --- Microbiology

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Questo testo si indirizza prima di tutto agli studenti delle Lauree Specialistiche in Biologia delle Università, ma sarà di interesse anche per studenti di Scienze Naturali e Medicina. Gli argomenti trattati includono i piu' classici modelli matematici di fenomeni biologici (dinamica delle popolazioni, diffusione delle malattie infettive, semplici modelli di fisiologia), ma una parte rilevante del testo e' dedicata all'approccio matematico alla teoria dell'evoluzione natuturale. Gli unici prerequisiti richiesti al lettore sono quelli forniti dai corsi di base di Matematica della Laurea triennale in Biologia, Scienze Naturali o Medicina; gli altri strumenti matematici sono discussi nel testo o nei "complementi matematici" che ne formano parte integrante. Sebbene i modelli qui discussi siano essenzialmente in termini di (semplici) equazioni differenziali e dunque deterministici, tesi a descrivere l'evoluzione di quantita' medie, si e' a piu' riprese cercato di mostrare il ruolo delle fluttuazioni nei fenomeni biologici e come esso possa essere tenuto in conto in modo matematicamente semplice.

Biological models. --- Biology --- Mathematical models. --- Biological models --- Biomathematics --- Models, Biological --- Genetics --- Physiology --- Mathematical and Computational Biology. --- Genetics and Population Dynamics. --- Physiological, Cellular and Medical Topics. --- Biological and Medical Physics, Biophysics. --- Mathematics. --- Animal physiology --- Animals --- Anatomy --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Biomathematics. --- Biophysics. --- Biological physics. --- Biological physics --- Medical sciences --- Physics --- Mathematics

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Genetics --- Genetics, Medical --- Hereditary Diseases --- Medical genetics --- Genetique medicale --- 575 --- General genetics. General cytogenetics. Immunogenetics. Evolution. Speciation. Phylogeny --- Basic Sciences. Genetics --- Genetics (General) --- 575 General genetics. General cytogenetics. Immunogenetics. Evolution. Speciation. Phylogeny --- Genetics (General). --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Genetic aspects --- Genetics - atlas --- Genetics, Medical - atlases --- Genetics - Atlases --- Medical genetics - Atlases --- Genetics, Medical - handbooks --- Genetique medicale - Atlas