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Cellular signal transduction --- Genetic regulation --- Control theory --- Gene Expression Regulation --- Genomics --- Models, Theoretical --- Signal Transduction

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Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volumes 1 & 2, present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer and neurodegenerative diseases. These comprehensive volumes integrate the most innovative and current findings from several related disciplines of scientific research, including pathology, genetics, virology, cell biology, immunology, and molecular biology. Volume 1 is divided into two sections: "Malignant Transformation and Metastasis" and "Molecular Basis of Disease Therapy." Volume 2 follows a similar structure and is divided into sections entitled "Kinases and Phosphate" and "Molecular Basis of Cell Death." All of the contributors are at the forefront of scientific discovery, and the reviews they present systemically examine the most exciting and innovative aspects of their particular areas of expertise. Researchers will find these volumes of major benefit as they search for novel and more effective treatments for human diseases.

Apoptosis. --- Pathology, Molecular. --- Cellular signal transduction. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Molecular pathology --- Molecular biology --- Physiology, Pathological --- Cell death

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Exocytosis is a fundamental cellular process that is used by eukaryotic cells to release a variety of biological compounds including peptide hormones and neurotransmitters or to insert specific lipids and proteins in the plasma membrane. In recent years, a multidisciplinary approach promoted an extraordinary progress in the understanding of the molecular mechanisms regulating exocytosis. This led to the discovery of a large number of components belonging to the machinery that governs the fusion of secretory vesicles with plasma membranes in different cell systems, including neuronal and endocrine cells. The basic machinery required for vesicle fusion turned out to be well conserved through evolution from yeast to man. So far, because of the large number of components involved, understanding of the molecular basis of exocytosis has remained the privilege of a relatively small group of specialists. This book, written by recognized experts in the field aims at clarifying for a non-specialist audience the role of the key players in the exocytotic process not only in neuronal and endocrine cells but also in a variety of other relevant cell systems. The book represents a unique collection of up-to-date reviews that will introduce researchers and students to the forefront of this rapidly moving and fascinating field.

Exocytosis. --- Cellular signal transduction. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Reverse pinocytosis --- Cell physiology --- Cytology. --- Neurobiology. --- Neurosciences. --- Cell Biology. --- Neurosciences --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Cell biology.

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Multicellular organisms must be able to adapt to cellular events to accommodate prevailing conditions. Sensory-response circuits operate by making use of a phosphorylation control mechanism known as the ""two-component system."" Sections include: Computational Analyses of Sequences and Sequence Alignments Biochemical and Genetic Assays of Individual Components of Signaling Systems Physiological Assays and Readouts* Presents detailed protocols * Includes troubleshooting tips

Cellular signal transduction. --- Chemotaxis. --- Signal Transduction. --- Enzymology. --- Phosphoproteins -- Physiological effect. --- Protein kinases. --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Chemiotaxis --- Chemotropism --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Biochemistry --- Growth --- Taxes (Biology) --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology

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he hedgehog signalling pathway is highly conserved and seen in organisms ranging from Drosophila to humans. This pathway is Tcritical in determining cell fate decisions in a variety of different cell types. There are several vertebrate analogues of the Drosophila hedgehog protein of which the most widely studied is Sonic hedgehog (Shh). Shh signalling classically involves the Gli family of zinc-fmger transcription factors. The Shh signalling pathway is well characterised in the develop­ ment of a number of vertebrate organ systems. It could indeed be argued that the Shh and Gli signalling may well be involved at some stage in the development of all the major organ systems in vertebrates. This volume rep­ resents a concerted drive to bring together *state of the art' reviews by lead­ ing experts in the field of Shh and Gli signalling in development from all over the world. The chapters span vertebrate organisms from zebrafish to humans and cover development of the multiple organ systems in which the Shh signalling pathway is crucial for normal development. There are chap­ ters on the development of the central nervous system, skeletal struc­ tures, visceral organs, prostate, lung, immune system and the structures of the human face. The authors themselves span three major continents and multiple nationalities which admirably illustrates the worldwide nature of the science.

Cellular signal transduction. --- Developmental genetics. --- Embryonic Induction. --- Embryonic Induction - physiology. --- Morphogenesis - Molecular aspects. --- Morphogenesis. --- Organogenesis. --- Organogenesis - physiology. --- Signal Transduction. --- Signal Transduction - physiology. --- Transcription factors. --- Transcription Factors - genetics. --- Morphogenesis --- Transcription factors --- Cellular signal transduction --- Developmental genetics --- Biochemical Processes --- Embryonic and Fetal Development --- Biology --- Cell Communication --- Proteins --- Embryonic Development --- Body Patterning --- Cell Differentiation --- Cell Physiological Processes --- Biological Science Disciplines --- Amino Acids, Peptides, and Proteins --- Chemical Processes --- Reproduction --- Cell Physiological Phenomena --- Natural Science Disciplines --- Biochemical Phenomena --- Growth and Development --- Disciplines and Occupations --- Chemicals and Drugs --- Phenomena and Processes --- Chemical Phenomena --- Reproductive Physiological Processes --- Physiological Processes --- Reproductive Physiological Phenomena --- Reproductive and Urinary Physiological Phenomena --- Physiological Phenomena --- Signal Transduction --- Embryonic Induction --- Organogenesis --- Genetics --- Physiology --- Transcription Factors --- Health & Biological Sciences --- Biophysics --- Molecular aspects --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Genetic transcription factors --- Molecular aspects. --- Life sciences. --- Human physiology. --- Cell biology. --- Developmental biology. --- Life Sciences. --- Developmental Biology. --- Cell Biology. --- Human Physiology. --- Development (Biology) --- Growth --- Ontogeny --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Human biology --- Medical sciences --- Human body --- Biosciences --- Sciences, Life --- Science --- Developmental biology --- Embryology --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Molecular biology --- Cytology.