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Molecular mechanisms of cancer
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ISBN: 1402060165 1402060157 9048175054 Year: 2007 Publisher: Dordrecht : Springer,

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Abstract

Cancer may constitute the most extensively studied functions constitute a second line of defense that disease entity of our time. Nevertheless, our com- protects against transforming defects in oncogenes prehension of the cellular and molecular pathology or tumor-suppressor genes and are here considered of malignant transformation is incomplete. In view as metasuppressor genes. Advances in the molecular of the diverse clinical presentations of various explanations of growth dysregulation, metastasis malignancies, doubts may be raised as to whether it formation, extension of life span, and loss of ma- is appropriate to refer to cancer as one group of dis- tenance of genomic and epigenetic integrity in ease states. The notion of malignant tumors as a cancer suggest models for their causal connection. pathologic and pathophysiologic class of conditions The mechanisms of growth control, senescence, and begs the question for defining criteria that charac- anchorage dependence are linked on the molecular terize all malignant growths, regardless of their tis- level (Chapter 8). In cells that are not fully differ- sue of origin. Toward this goal, the recognition that tiated, the overactivation of oncogene pathways tumor development is caused by the dysregulation also induces the expression of metastasis genes. of growth-controlling genes (oncogenes and tumor- Telomerase, the enzyme that prevents cell sen- suppressor genes) has advanced our mechanistic cence, is expressed in these precursor cells and may understanding of oncology (Chapter 3). However, be further activated by growth factor signaling.

Apoptosis and senescence, and cancer
Authors: --- ---
ISBN: 1617376213 1588295273 9786611116897 1281116890 1597452211 Year: 2007 Publisher: Totowa, N.J. : Humana Press,

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Abstract

Apoptosis, Senescence and Cancer provides insight into established practices and research into apoptosis and senescence by thoroughly examining novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers. The volume is divided into six easy to follow sections. The first is Apoptosis and Alternative Modes of Cell Death, followed by chapters on Telomeres and Telomerase, Senescence, Genomic Instability and Tumorigenesis. The third part covers DNA Damage Response, Signaling Pathways and Tumorigenesis, while the fourth delves into Resistance and Sensitization. The book concludes with Established Cancer Therapies and a section which looks toward the future with Recent and Developing Cancer Therapies. In total, this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment, both in the initial stages of the disease as well as in disease recurrence.

Keywords

Apoptosis. --- Cancer. --- Cancer cells. --- Cancer cells --- Cancer --- Apoptosis --- Genetic Processes --- Genetic Phenomena --- Neoplastic Processes --- Pathologic Processes --- Diseases --- Cell Physiological Processes --- Cell Death --- Mutation --- Cell Physiological Phenomena --- Pathological Conditions, Signs and Symptoms --- Genetic Variation --- Phenomena and Processes --- Neoplasms --- DNA Damage --- Cell Aging --- Genomic Instability --- Cell Transformation, Neoplastic --- Medicine --- Health & Biological Sciences --- Radiology, MRI, Ultrasonography & Medical Physics --- Oncology --- Growth --- Regulation --- Chemotherapy --- Radiotherapy --- Regulation. --- Chemotherapy. --- Radiotherapy. --- Regulation of cancer cell growth --- Medicine. --- Cancer research. --- Pharmacology. --- Nuclear medicine. --- Oncology. --- Medicine & Public Health. --- Cancer Research. --- Nuclear Medicine. --- Pharmacology/Toxicology. --- Tumors --- Radiation therapy --- Electrotherapeutics --- Hospitals --- Medical electronics --- Medical radiology --- Therapeutics, Physiological --- Phototherapy --- Atomic medicine --- Radioisotopes in medicine --- Radioactive tracers --- Radioactivity --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Drugs --- Pharmacy --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Radiological services --- Physiological effect --- Cell death --- Antineoplastic agents --- Biological control systems --- Cellular control mechanisms --- Treatment --- Oncology  . --- Toxicology. --- Pharmacology --- Poisoning --- Poisons --- Toxicology

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