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Fundamentals of Protein Structure and Function Engelbert Buxbaum, Dr. rer. nat. This book serves as an introduction to the fundamentals of protein structure and function. Starting with their make up from simple building blocks called amino acids, the 3-dimensional structure of proteins is explained. This is followed by an introduction into enzymology and modern concepts of enzyme kinetics, taking into account the physiological and medical significance of this often neglected topic. Also covered in the text are enzymes, biocatalysts, enzyme kinetics, hemoglobin, myoglobin, prion proteins, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins into mitochondria, transport of proteins between cell compartments, transport of solutes across membranes, analytic techniques, protein-ligand interactions, protein purification, and protein structure, size and shape, emphasizing the link between protein structure, physiological function and medical significance. This book is an introductory text for researchers in protein biochemistry, molecular biology, cell biology, chemistry, biophysics and biomedical research. The book also makes an ideal textbook for graduate and advanced undergraduate courses in protein structure and function, and a supplementary text for related courses. About the Author Dr. Buxbaum is a biochemist with interest in enzymology and protein science. Dr. Buxbaum has been working on the biochemistry of membrane transport proteins for almost 20 years and has taught courses in biochemistry and molecular medicine at several universities. "The analytical descriptions of structure, biophysics and function of proteins is an extremely important aspect of today's education in biochemistry." Martin Sagermann, Ph.D. University of California, Santa Barbara

Proteins --- Structure --- Protein Conformation --- 577.122 --- 577.122 Protein metabolism --- Protein metabolism --- Conformation, Protein --- Conformations, Protein --- Protein Conformations --- Protein Folding --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- physiology --- Proteins - Structure

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One of the great unsolved problems of science and also of physics is the prediction of the three dimensional structure of a protein from its amino acid sequence. It may be stated that the deep connection existing between physics and protein folding is not so much, or in any case not only, through physical methods, but through physical concepts.

Drugs --- Protein folding --- Folding of proteins --- Proteins --- Design --- Folding --- Conformation --- Drug design

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Volume 2 of this two-volume sequence focuses on protein structure prediction and includes protein threading, De novo methods, applications to membrane proteins and protein complexes, structure-based drug design, as well as structure prediction as a systems problem. A series of appendices review the biological and chemical basics related to protein structure, computer science for structural informatics, and prerequisite mathematics and statistics.

Computational biology --- Proteins --- 577.122 --- 577.122 Protein metabolism --- Protein metabolism --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Protein conformation --- Biology --- Bioinformatics --- Conformation --- Structure --- Structure&delete& --- Mathematical models --- Computational biology. --- Structure. --- Conformation. --- Mathematical models. --- Proteomics. --- Bioinformatics. --- Biological and Medical Physics, Biophysics. --- Bio-informatics --- Biological informatics --- Information science --- Systems biology --- Molecular biology --- Data processing --- Biophysics. --- Biological physics. --- Biological physics --- Medical sciences --- Physics

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Protein Misfolding, Aggregation and Conformational Diseases, Part B: Molecular Mechanisms of Conformational Diseases, is a comprehensive volume providing a broad and detailed discussion of the relationships of protein misfolding and aggregation with the pathogenesis of numerous conformational diseases. While the Part A was dedicated to the description of the general mechanisms underlying protein misfolding, aggregation, and development of protein deposition disorders, this volume summarizes recent achievements in the understanding of the molecular mechanisms of conformational diseases. Research indicates that these mechanisms are highly diverse and range from the altered protein structure leading to the enhanced propensity for aggregation/deposition or the impaired functions and ending with changes in supra-molecular structures or posttranslational modification. Protein Misfolding, Aggregation and Conformational Diseases, Part B: Molecular Mechanisms of Conformational Diseases, is an ideal book for pharmaceutical scientists, molecular and cellular biologists, biochemists, immunologists, protein scientists, and biophysicists.

Protein folding. --- Cell aggregation. --- Proteins --- Pathophysiology. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Aggregation, Cell --- Cell patterning --- Cell interaction --- Microbial aggregation --- Folding of proteins --- Folding --- Conformation --- Immunology. --- Cytology. --- Cell Biology. --- Immunobiology --- Life sciences --- Serology --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cell biology.

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Prions --- Protein folding --- Prions. --- Protein folding. --- Folding of proteins --- Proteins --- Infectious protein particles --- Prion proteins --- Protein particles, Infectious --- Proteinaceous infection particles --- PrP proteins --- Folding --- Protein Folding --- Conformation --- Protein Folding, Globular --- Folding, Globular Protein --- Folding, Protein --- Foldings, Globular Protein --- Foldings, Protein --- Globular Protein Folding --- Globular Protein Foldings --- Protein Foldings --- Protein Foldings, Globular --- Proteostasis --- Protein Multimerization --- Intrinsically Disordered Proteins --- Mink Encephalopathy Virus --- Encephalopathy Virus, Mink --- Scrapie --- Agriculture Sciences --- Soil Chemistry, Microbiology, Fertility & Fertilizers --- Prion --- protein folding --- protein assembly disorders --- prion diseases --- prions --- Protein Folding.