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This volume contains the main proceedings of the fourth international conference on "Cancer Prevention 2006," which was held during February 16–18, 2006, in St. Gallen, Switzerland. Written by international experts in the field, the book comprises a comprehensive update on the most recent developments in the upsurging fields of molecular biology and cancer genetics and their interactions with clinical epidemiology and cancer prevention at various levels: genetic/biologic predisposition and definition of high-risk groups; preclinical models and tumor prevention; prospects of surrogate endpoints and biomarkers; progress in imaging and detection of neoplastic precursor lesions; problems with Cox-2 inhibitors in tumor chemoprevention; primary and secondary prevention of gynecological, breast, gastrointestinal and genitourinary cancers. In addition, the future prospects of cancer chemoprevention are discussed.

Cancer --- Oncology --- Prevention --- Tumors

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Target Discovery and Validation Reviews and Protocols, Volumes 1 and 2 review the most progressive and current methods for drug target discovery and validation. These volumes explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders. Volume 1 focuses on novel and innovative techniques, and presents the most up-to-date protocols available for maximizing the likelihood of achieving target-selective inhibition in vivo while minimizing side effects. The profound impact of genomics, proteomics and bioinformatics on target discovery is explored, and specific attention is given to the role of transgenic and knockout animals in functional genomics and target validation. Cancer researchers will find tremendous value in the molecular classification of breast cancers and the review of protocols for tumor antigens and cancer vaccines. The methods and protocols collected here, all reviewed by leading scientists and clinicians, present the practical details necessary for translating the enormous discovery potential of the genome into real therapeutic products. Volume 2 collects all the practical details required for efficient translation of discovered targets into real pharmaceutical drugs. Specific targets in cancers and autoimmunity are described and the potential of using siRNAs, antisense oligonucleotides and RNA aptamers in patients is reviewed. This volume explores the tremendous impact of the application of genotyping and gene expression profiling on the future of healthcare, and presents cutting-edge protocols to aid in bringing agents against specific targets closer to application in the clinic. Collectively, these volumes provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application. For researchers, an understanding of available methods aids in the creation of innovative experiments in the laboratory, and the successful translation of target discovery to real therapeutics.

Oncology  . --- Oncology. --- Tumors

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Hemangiomas and superficial vascular malformations are disfiguring birthmarks that can occur over 65% of a child's body. This atlas will focus on the classification, multidisciplinary approach, recognition and identification, and treatment options for this class of pathology. Vascular malformations, composed of malformed vessels, never regress and sometimes expand rapidly. They occur in any body part including viscera. They cause cosmetic problems, functional disability and can be life threatening and require radiologic imaging and pathology to recognize and perform differential diagnosis on various vascular anomalies. In addition, new techniques, including molecular biology procedures, have evolved allowing less invasive and a more effective approach to diagnosis and treatment.

Blood-vessels --- Tumors --- Abnormalities

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T is is the first edition of Pediatric Lymphomas. Treatment of both Hodgkin and non-Hodgkin lymphomas, editors have been colleagues for more than 25 years and lymphoproliferative disorders associated with - and have been involved in the design and coordination immunodeficiency. In addition, three chapters focus on of clinical trials and multimodality approaches for the pathology, molecular biology, and genetics of children with Hodgkin and non-Hodgkin lymphomas. Hodgkin and non-Hodgkin lymphoma including the Progress in elucidating the pathogenesis and in the di- rare cutaneous lymphomas. We hope that Pediatric agnosis and treatment of lymphomas in children has Lymphomas will be a useful resource for practitioners been one of the great success stories in pediatric oncology from the many different disciplines involved in the. Prior to 1970, fewer than 20% of children with comprehensive care of children with lymphomas. malignant lymphomas survived. Today, more than T e authors are all leading experts in the area of 90% of children diagnosed with Hodgkin lymphoma childhood lymphomas. We wish to thank them for all survive and more than 80% of children with non- of the time and effort that went into their contributions.- Hodgkin lymphoma are considered cured. If this first edition is helpful to our diverse re- improvement in survival has occurred as the result of ership, it is because of the authors.

Lymphomas in children. --- Tumors in children. --- Pediatric oncology --- Children --- Tumors in children --- Diseases

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Hemangiomas and superficial vascular malformations are disfiguring birthmarks that can occur over 65% of a child's body. This atlas will focus on the classification, multidisciplinary approach, recognition and identification and treatment options for this class of pathology. Vascular malformations, composed of malformed vessels, never regress and sometimes expand rapidly. They occur in any body part including viscera. They cause cosmetic problems, functional disability and can be life threatening and require radiologic imaging and pathology to recognize and perform differential diagnosis on various vascular anomalies. In addition, new techniques, including molecular biology procedures, have evolved allowing less invasive and a more effective approach to diagnosis and treatment.

Arteriovenous Malformations --- Blood-vessels --- Vascular Neoplasms --- Abnormalities --- Tumors